Exploration of genes involved in susceptibility to thiamin (vitamin B1) deficiency
| Project/Area Number |
20500715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fukuoka Women's University |
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Principal Investigator |
HAMADA Shun Fukuoka Women's University, 人間環境学部, 教授 (60282349)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Kayoko 福岡女子大学, 人間環境学部, 学術研究員 (20448814)
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| Co-Investigator(Renkei-kenkyūsha) |
YAGI Takeshi 大阪大学, 大学院・生命機能研究科, 教授 (10241241)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食と栄養 / ビタミン / 栄養学 / 生体分子 / 脳神経疾患 / 遺伝子 / 脳・神経 / ビタミンB1 / 細胞死 |
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| Research Abstract |
Wernicke-Korsakoff syndrome is a neuropsychiatric disorder resulting from thiamin deficiency (vitamin B1). It has been believed that genetic factors are important in its pathogenesis because of inter-individual and inter-regional differences in susceptibility to this disorder. In this project, we explored genetic factors by using a mouse strain which shows higher sensitivity to thiamin deficiency than the other strains. Our results from interbreeding of this strain combined with experimental thiamin deficiency suggest that multiple genes are involved in susceptibility to thiamin deficiency, and that at least one of them is located in mitochondrial DNA.
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Report
(4 results)
Research Products
(27 results)
