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Study of effects of alcohol intake on fat-soluble nutrients metabolisms and their mechanisms.

Research Project

Project/Area Number 20500716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of Nagasaki

Principal Investigator

SURUGA Kazuhito  University of Nagasaki, 看護栄養学部, 准教授 (70315852)

Co-Investigator(Renkei-kenkyūsha) YAMAGUCHI Noriaki  長崎県立大学, 看護栄養学部, 助教 (80516295)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアルコール / 脂溶性栄養素 / ビタミンA / β-カロテン / 肝障害 / 炎症性サイトカイン / 機能性食品成分 / ベータカロテン / 中佐脂肪酸 / 脂肪肝 / TNFα / NO / MTP / マイクロソームトリグリセリド輸送タンパク質
Research Abstract

As well as increased hepatic lipogenesis and decreased hepatic lipid oxidation, decreased level of hepatic lipid secretion-related gene expression may involve in the onset of chronic alcohol intake-induced hepatic steatosis in rats. In addition, the gene expression level involved in the conversion of beta-catotene into vitamin A in the small intestine decreased in the rats fed alcohol chronically, which may explain the alcohol-induced hypovitaminosis A.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Hepatocyte nuclear factor-4α regulates human cellular retinol-binding protein type II gene expression in intestinal cells.2009

    • Author(s)
      Yamaguchi, N., Miyamoto, S., Goda, T., Suruga, K.
    • Journal Title

      Am.J.Physiol.Gastroenterol.Liver Physiol.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 肥満発症ラットOLETFの脂肪組織および3T3L-1脂肪細胞におけるビタミンA代謝関連遺伝子の変動2010

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      第33回日本分子生物学会、第83回日本生化学会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] スナねずみのβ-カロテン開裂酵素の遺伝子発現と食餌条件による影響2010

    • Author(s)
      駿河和仁、李翔、山田みな穂、山口範晃
    • Organizer
      第64回日本栄養食糧学会大会
    • Place of Presentation
      徳島市
    • Year and Date
      2010-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト小腸のβ-カロテン開裂酵素の遺伝子発現に及ぼすHNF-1αとHNF-4αの影響2009

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      第63回日本・栄養食糧学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト小腸様細胞株C2BBe1細胞のCRBPIIとBCMO1遺伝子発現に及ぼすHNF-4αの影響2008

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      第31回日本分子生物学会、第81回日本生化学会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト小腸様細胞株C2BBe1細胞のCRBPII遺伝子発現に及ぼすHNF-4αの影響2008

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      第62回日本栄養食糧学会大会
    • Place of Presentation
      埼玉県和光市
    • Year and Date
      2008-05-03
    • Related Report
      2010 Final Research Report
  • [Presentation] アルコール摂取によるラットのβ-カロテン吸収・代謝に及ぼす影響2008

    • Author(s)
      駿河和仁、青野由美、福井翔吾、山口範晃
    • Organizer
      第62回日本栄養食糧学会大会
    • Place of Presentation
      埼玉県和光市
    • Year and Date
      2008-05-03
    • Related Report
      2010 Final Research Report
  • [Presentation] アルコール摂取によるラットのβ-カロテン吸収・代謝に及ぼす影響2008

    • Author(s)
      駿河和仁, 青野由美, 福井翔吾, 山口範晃
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      埼玉県
    • Related Report
      2008 Annual Research Report
  • [Book] 医科栄養学'ビタミンA'2010

    • Author(s)
      加藤滋子、駿河和仁、宗正敏(分担執筆)
    • Publisher
      建帛社
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://sun.ac.jp/research/researcher/pdf/suruga.pdf

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://sun.ac.jp/research/researcher/pdf/suruga.pdf

    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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