Association between the functional polymorphism of tissue-non specific alkaline phosphatase gene and mineral metabolism
| Project/Area Number |
20500725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Japan Women's University |
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Principal Investigator |
GOSEKI Masae Japan Women's University, 家政学部, 教授 (00170449)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アルカリホスファターゼ / ミネラル代謝 / 骨粗鬆症 / 骨密度 / 遺伝子多型 / 栄養因子 / 骨量調節 |
|---|
| Research Abstract |
Alkaline phosphatase (ALP) hydrolyzes a variety of monophoshate esters, and tissue-nonspecific ALP (TNSALP) is indispensable for bone mineralization. Bone mass seems to be determined by genetic as well as environmental factors. In this study, we demonstrated the effects of the TNSALP genotype on associations among serum bone metabolism markers. Our data may be useful for the regulation of mineral metabolism including the phosphate metabolism pathway.
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Report
(4 results)
Research Products
(28 results)
