Association between the functional polymorphism of tissue-non specific alkaline phosphatase gene and mineral metabolism

• Project/Area Number: 20500725
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Japan Women's University
• Principal Investigator: GOSEKI Masae Japan Women's University, 家政学部, 教授 (00170449)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: アルカリホスファターゼ / ミネラル代謝 / 骨粗鬆症 / 骨密度 / 遺伝子多型 / 栄養因子 / 骨量調節

Research Abstract

Alkaline phosphatase (ALP) hydrolyzes a variety of monophoshate esters, and tissue-nonspecific ALP (TNSALP) is indispensable for bone mineralization. Bone mass seems to be determined by genetic as well as environmental factors. In this study, we demonstrated the effects of the TNSALP genotype on associations among serum bone metabolism markers. Our data may be useful for the regulation of mineral metabolism including the phosphate metabolism pathway.

Research Products

• [Journal Article] Vitamin K1 (phylloquinone) or vitamin K_2 (menaquinone-4) induces intestinal alkaline phosphatase gene expression (2011)
  • Author(s): Haraikawa M, Sogabe N, Tanabe R, Hosoi T, Goseki-Sone M
  • Journal Title: Journal of Nutritional Science and Vitaminology (in press)
  • Peer Reviewed
• [Journal Article] Reply to Letter to the Editor "Vitamin K family effects on bone growth" (2011)
  • Author(s): 五関-曽根正江
  • Journal Title: Bone 48 Pages: 1428-1428
  • Peer Reviewed
• [Journal Article] Effects of long-term vitamin K_1 (phylloquinone) or vitamin K_2 (menaquinone-4) supplementation on body composition and serum parameters in rats. (2011)
  • Author(s): Sogabe N, Maruyama R, Baba O, Hosoi T, Goseki-Sone M
  • Journal Title: Bone 48 Pages: 1036-1042
  • Peer Reviewed
• [Journal Article] Effects of lont-term vitamin K_1, (phylloquinone) or vitamin K_2, (menazuinone-4) supplementation on body composition and serum parameters in Rats. (2011)
  • Author(s): Goseki-Sone M., et.al.
  • Journal Title: Bone Volume: 48 Pages: 1036-1042
  • Peer Reviewed
• [Journal Article] Expression of intestinal-type alkaline phosphatase mRNA in liver of Akp3 knockout mice. (2010)
  • Author(s): Goseki-Sone M, Sogabe N, Nakano T, Tanabe R, Haraikawa M, Alpers D.H, Komoda T
  • Journal Title: J Electrophoresis 54 Pages: 27-32
  • Peer Reviewed
• [Journal Article] Expression of intestinal-type alkaline phosphatase mRNA in liver of Akp3 knockout mice. (2010)
  • Author(s): Goseki-Sone M., et.al.
  • Journal Title: Journal of Electrophoresis Volume: 54 Pages: 27-32
  • Peer Reviewed
• [Journal Article] 大学生におけるボディ・マス・インデックスと食生活および骨量との関連性について (2009)
  • Author(s): 曽我部夏子、丸山里枝子、佐藤和人、五関-曽根正江
  • Journal Title: 栄養学雑誌 67 Pages: 58-64
  • Peer Reviewed
• [Journal Article] Molecular effects of the tissue-nonspecific alkaline phophatase gene polymorphism (787T>C) associated with bone mineral density. (2008)
  • Author(s): Sogabe N, Oda K, Nakamura H, Orimo H, Watanabe H, Hosoi T, Goseki-Sone M
  • Journal Title: Biomedical Research 29 Pages: 213-219
  • Peer Reviewed
• [Journal Article] 特集:ゲノムからみた骨・関節疾患Seminar.「Nutrigenomics の可能性」 (2008)
  • Author(s): 五関-曽根正江
  • Journal Title: CLINICAL CALCIUM 2(執筆依頼) Pages: 46-51
• [Presentation] Association between serum bone-specific alkaline phosphatase activity and biochemical markers, dietary nutrients, and functional polymorphism of the tissue-nonspecific alkaline phosphatase gene in healthy young adults. (2010)
  • Author(s): 曽我部夏子, 五関-曽根正江
  • Organizer: 32th ASBMR (Annual Meeting of the American Society for Bone and Mineral Research)
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2010-10-18
• [Presentation] Association between serum bone-specific alkaline phosphatase activity and biochemical markers, dietary nutrients, and functional polymorphism of the tissue-nonspecific alkaline Phosphatase gene in healthy young adults. (2010)
  • Author(s): Goseki-Sone M., et.al.
  • Organizer: 32th The American Society for Bone and Mineral Research アメリカ骨代謝学会
  • Place of Presentation: Metro Toronto Convention Center (Tronto, Canada)
  • Year and Date: 2010-10-18
• [Presentation] 若年成人における臓器非特異型アルカリホスファターゼ遺伝子多型と骨代謝マーカーおよび栄養摂取状況の関連 (2010)
  • Author(s): 曽我部夏子, 五関-曽根正江
  • Organizer: 第57回日本栄養改善学会
  • Place of Presentation: 埼玉県
  • Year and Date: 2010-09-12
• [Presentation] 若年成人における臓器非特異型アルカリホスファターゼ遺伝子多型と骨代謝マーカーおよび栄養摂取状況の関連 (2010)
  • Author(s): 五関-曽根正江, 他
  • Organizer: 第57回日本栄養改善学会
  • Place of Presentation: 埼玉県坂戸市
  • Year and Date: 2010-09-12
• [Presentation] 若年成人における栄養摂取状況と骨代謝マーカーおよび臓器非特異型アルカリホスファターゼ遺伝子多型の関連 (2010)
  • Author(s): 五関-曽根正江, 他
  • Organizer: 第57回日本栄養・食糧学会
  • Place of Presentation: 徳島県徳島市
  • Year and Date: 2010-05-23
• [Presentation] マウスにおけるビタミンK経口投与によるアルカリホスファターゼ遺伝子発現への影響 (2010)
  • Author(s): 祓川摩有, 五関-曽根正江
  • Organizer: 第13回日本病態栄養学会
  • Place of Presentation: 京都
  • Year and Date: 2010-01-10
• [Presentation] 若年成人におけるカルシウム摂取状況と骨型アルカリホスファターゼとの関連について (2010)
  • Author(s): 曽我部夏子, 五関-曽根正江
  • Organizer: 第13回日本病態栄養学会
  • Place of Presentation: 京都
  • Year and Date: 2010-01-10
• [Presentation] マウスにおけるビタミンK経口投与によるアルカリホスファターゼ遺伝子発現への影響 (2010)
  • Author(s): 五関-曽根正江, 他
  • Organizer: 第13回 日本病態栄養学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-01-10
• [Presentation] 若年成人におけるカルミウム摂取状況と骨型アルカリホスファターゼとの関連について (2010)
  • Author(s): 五関-曽根正江, 他
  • Organizer: 第13回 日本病態栄養学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-01-10
• [Presentation] Effects of vitamin K_1 or vitamin K_2 on bone metabolism in growing female rats. (2009)
  • Author(s): 曽我部夏子, 五関-曽根正江
  • Organizer: 31th ASMBMR SU0063
  • Place of Presentation: Denver, USA
  • Year and Date: 2009-09-13
• [Presentation] Effects of vitamin K_1 (phylloquinone) or vitamin K_2 (menaquinone-4) on bone metabolism in growing female rats. (2009)
  • Author(s): Goseki-Sone M., et al.
  • Organizer: 31th The American Society for Bone and Mineral Research
  • Place of Presentation: Colorado Convention Center (Denver, USA)
  • Year and Date: 2009-09-13
• [Presentation] Effects of alkaline phosphatase activity in the rat kidney by lactose or high-fat feeding. (2009)
  • Author(s): Goseki-Sone M., et al.
  • Organizer: 8th Interantional meeting of research group for alkaline phosphatase (ALPS研究会)
  • Place of Presentation: 新潟大学歯学部(新潟)
  • Year and Date: 2009-07-25
• [Presentation] Calcium intake and serum bone formation markers are associated with the functional single nucleotide polymorphism in the tissue- nonspecific alkaline phosphatase gene. (2008)
  • Author(s): 五関-曽根正江
  • Organizer: 30th ASBMR
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2008-09-14
• [Presentation] Nutritional effects of the tissue-nonspecific alkaline phosphatase gene polymorphism associated with bone mineral density. (2008)
  • Author(s): 曽我部夏子, 五関-曽根正江
  • Organizer: 15th ICD (International Congress of Dietetics)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2008-09-10
• [Presentation] ラット小腸アルカリホスファターゼ活性へ及ぼすビタミンK_1またはビタミンK_2経口投与の影響について (2008)
  • Author(s): 曽我部夏子, 五関-曽根正江
  • Organizer: 第60回日本家政学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-31
• [Presentation] ビタミンK_1またはビタミンK_2経口投与によるラット小腸アルカリホスファターゼ活性誘導作用について (2008)
  • Author(s): 曽我部夏子, 五関-曽根正江
  • Organizer: 第62回日本栄養・食糧学会
  • Place of Presentation: 埼玉県
  • Year and Date: 2008-05-03
• [Presentation] Effects of tissue-nonspecific alkaline phosphatase gene polymorphism on the relationship between dietary nutrient intake and serum markers of bone metabolism. (2008)
  • Author(s): 五関-曽根正江
  • Organizer: International Mini-Symposium on Alkaline Phosphatase.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-04-26
• [Remarks] ホームページ等
  • URL: http://mcm-www.jwu.ac.jp/~goseki/
• [Remarks]
  • URL: http://mcm-www.jwu.ac.jp/~goseki/goseki.html