Studies on the biological effects and mode of action of pollutants in marine animals
Project/Area Number |
20510060
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Hokkaido University |
Principal Investigator |
AZUMI Kaoru Hokkaido University, 環境健康科学研究教育センター, 特任講師 (90221720)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 海産動物 / 無脊椎動物 / ホヤ / DNAマイクロアレイ / 遺伝子発現 / 有機スズ / 重金属 / 内分泌撹乱物質 / 海洋汚染 / 鉛フリーはんだ / ストレス応答 / 化学物質 / 金属イオン |
Research Abstract |
We obtained gene expression profile data from ascidians after exposure to organotin compounds, metal ions, or endocrine disruptors for 72h. We then categorized the up- or down-regulated genes for each pollutant using our classification method, and estimated the biological effects of each pollutant. We developed high-throughput methods for screening embryogenesis and metamorphosis using ascidian eggs and larva, and analyzed the inhibitory effects of each pollutant. Furthermore, we found nine marker genes for monitoring environmental contamination due to organotins.
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Report
(4 results)
Research Products
(33 results)
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[Book] Biological Responses to Chemical Pollutants-Interdisciplinary Studies on Environmental Chemistry Vol.1,(Eds., Y.Murakami, K.Nakayama, S.Kitamura, H.Iwata and S.Tanabe)(Application of ascidian DNA microarray analysis for risk assessment of marine chemical pollutants.)2008
Author(s)
Kaoru Azumi, Shinjiro Amano, Sorin V.Sabau, Akiko Kamimura, Nori Satoh, Ryo Koyanagi.
Publisher
TERRAPUB, Tokyo
Related Report
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