| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We obtained gene expression profile data from ascidians after exposure to organotin compounds, metal ions, or endocrine disruptors for 72h. We then categorized the up- or down-regulated genes for each pollutant using our classification method, and estimated the biological effects of each pollutant. We developed high-throughput methods for screening embryogenesis and metamorphosis using ascidian eggs and larva, and analyzed the inhibitory effects of each pollutant. Furthermore, we found nine marker genes for monitoring environmental contamination due to organotins.
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