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Multi-dimensional Analysis of Protein Properties and Functional Control of Them by Using Vibration and Optical Methodologies

Research Project

Project/Area Number 20510100
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionTokyo Institute of Technology

Principal Investigator

KAWASAKI Takayoshi  Tokyo Institute of Technology, 大学院・生命理子学研究科, 助教 (60334504)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords水晶発振子 / 金異常反射 / 反射干渉分光法 / 酵素反応 / 振動効果 / リポソーム / DNA / 粘弾性 / 粘弾性測定 / プロテアーゼ
Research Abstract

In this study, we have developed dual mass sensing devices using a quartz crystal microbalance and optical film thickness measuring methods. As the optical system, we utilized newly developed an enhanced anomalous reflection of Au and a reflectometric interference spectroscopy using TiO2/Ti surface. Furthermore, with these simultaneous measuring systems, we could evaluate the physicochemical properties of protein, liposome, and DNA that adsorbed on the surface.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (18 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Covalent Modification of DNA with Azetidinium Lipids2010

    • Author(s)
      Yusuke Yonamine, Takayoshi Kawasaki, Yoshio Okahata
    • Journal Title

      Chemistry Letters 39

      Pages: 84-85

    • NAID

      10027176838

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laser Response of a Quartz Crystal Microbalance : Frequency Changes Induced by Light Irradiation in the Air Phase2009

    • Author(s)
      Takayoshi Kawasaki, Tetsuhiro Mochida, Jun-ichi Katada, Yoshio Okahata
    • Journal Title

      Analytical Sciences 25

      Pages: 1069-1075

    • NAID

      10025622524

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulse Frequency-dependent Regulation of the Lysozyme Reactivity under Pulsed Ultrasound Irradiation2009

    • Author(s)
      Takayoshi Kawasaki, Momoko Toyoda, Yoshio Okahata
    • Journal Title

      Chemistry Letters 38

      Pages: 538-539

    • NAID

      10025122654

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulsed Ultrasound Effect on DNA Polymerase Reaction Monitored on a QCM2009

    • Author(s)
      Takayoshi Kawasaki, Momoko Toyoda, Yu Hoshino, Yoshio Okahata
    • Journal Title

      Chemistry Letters 38

      Pages: 536-537

    • NAID

      10025122665

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulsed Ultrasound Effect on DNA Polymerase Reaction Monitored on a QCM2009

    • Author(s)
      Takayoshi Kawasaki, Momoko Toyoda, Yu Hoshino, Yoshio Okahata
    • Journal Title

      Chemistry Letters 38(In press)

    • NAID

      10025122665

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulse Frequency-dependent Regulation of the Lysozyme Reactivity under Pulsed Ultrasound Irradiation2009

    • Author(s)
      Takayoshi Kawasaki, Momoko Toyoda, Yoshio Okahata
    • Journal Title

      Chemistry Letters 38(In press)

    • NAID

      10025122654

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 光干渉-QCM同時測定法を用いた基板上でのリボソーム物性解析2011

    • Author(s)
      小島泰輔、川崎剛美、岡畑恵雄
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 光干渉-QCM 同時測定法を用いた基板上でのリポソーム物性解析2011

    • Author(s)
      小島泰輔
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 固体表面におけるプロテアーゼ反応のパルス振動効果2011

    • Author(s)
      川崎剛美、岡畑恵雄
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Measurements of Surface Absorbed Lipid Bilayer with a Combination Methodology of Reflective Interferometric Spectroscopy and a Quartz Crystal Microbalance2010

    • Author(s)
      小島泰輔
    • Organizer
      PacifiChem 2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of the DNA Viscoelasticity by using an AR-QCM method2010

    • Author(s)
      大塚雅徳
    • Organizer
      PacifiChem 2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低分子吸着と酵素反応における発振子表面の振動効果2010

    • Author(s)
      川崎剛美、岡畑恵雄
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 光干渉法と水晶発振子マイクロバランス法を組み合わせたリポソームの吸着過程の観察2010

    • Author(s)
      小島泰輔
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 反射干渉分光法を用いた圧電素子表面化学における振動効果の研究2010

    • Author(s)
      川崎剛美
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光反射型QCM法によるDNA鎖の物性評価2010

    • Author(s)
      大塚雅徳、川崎剛美、岡畑恵雄
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 光干渉法と水晶発振マイクロバランス法を組み合わせた表面吸着膜の測定2010

    • Author(s)
      川崎剛美
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光反射QCM法を用いたタンパク質の硬さに依存する加水分解反応2009

    • Author(s)
      川崎剛美、田中千香子、岡畑恵雄
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 光反射QCM法を用いたタンパク質の硬さに依存する加水分解反応2009

    • Author(s)
      川崎剛美
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学黒髪キャンパス
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光反射QCMの金基板の多重表面修飾による感度向上2009

    • Author(s)
      小島泰輔
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学黒髪キャンパス
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光反射QCM法の金基板表面修飾による感度向上2009

    • Author(s)
      川崎剛美
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      日本大学理工学部 船橋キャンパス
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 光反射QCM法を用いたタンパク質加水分解反応動力学の基質依存性2009

    • Author(s)
      田中千香子
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      日本大学理工学部 船橋キャンパス
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 光反射QCM法によるDNA鎖の水和状態と酵素反応の評価2009

    • Author(s)
      三ツ木淳吾
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      日本大学理工学部 船橋キャンパス
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 光反射QCM法によるDNA鎖上での反応解析2008

    • Author(s)
      川崎剛美
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪市立大学 杉本キャンパス
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 光反射QCM法を用いたタンパク質加水分解反応の解析2008

    • Author(s)
      田中千香子
    • Organizer
      第3回バイオ関連化学合同シンポジウム
    • Place of Presentation
      東京工業大学 すずかけ台キャンパス
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 反射光強度測定用積層構造体、反射光測定用積層構造体を含んでなる装置、並びに薄膜の膜厚及び/又は質量及び/又は粘度測定方法2011

    • Inventor(s)
      川暗剛美、岡畑恵雄
    • Industrial Property Rights Holder
      東京工業大学
    • Filing Date
      2011-03-10
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 反射光強度測定用積層構造体、反射光測定用積層構造体を含んでなる装置、並びに薄膜の膜厚及び/又は質量及び/又は粘土測定方法2011

    • Inventor(s)
      川崎剛美、岡畑恵雄
    • Industrial Property Rights Holder
      東京工業大学
    • Filing Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 反射スペクトル測定用積層構造および薄膜の膜厚測定方法2010

    • Inventor(s)
      川暗剛美、岡畑恵雄
    • Industrial Property Rights Holder
      東京工業大学
    • Filing Date
      2010-03-10
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 反射スペクトル測定用積層構造および薄膜厚測定方法2010

    • Inventor(s)
      川崎剛美、岡畑恵雄
    • Industrial Property Rights Holder
      東京工業大学
    • Industrial Property Number
      2010-053556
    • Filing Date
      2010-03-10
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 金属薄膜含有積層構造2009

    • Inventor(s)
      川崎剛美、岡畑恵雄
    • Industrial Property Rights Holder
      東京工業大学
    • Filing Date
      2009-03-11
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 金属薄膜含有積層構造2009

    • Inventor(s)
      川崎剛美, 岡畑恵雄
    • Industrial Property Rights Holder
      東京工業大学
    • Industrial Property Number
      2009-058611
    • Filing Date
      2009-03-11
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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