Spacio-temporal analysis of histone modification by FRET probes
Project/Area Number |
20510183
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
基礎ゲノム科学
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
TANAKA Yuujirou Tokyo Medical and Dental University, 大学院・疾患生命科学研究部, 准教授 (00311613)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | クロマチン構造 / ヒストン修飾 / メチル基転移酵素 / 脱メチル化酵素 / ヒストンメチル基転移酵素 / FRET / リジルエンドペプチダーゼ / 酵素活性 / FRETプローブ / 可視化 |
Research Abstract |
A new technique of visualization of histone modifying enzymes was established using FRET peptides and artificially engineered lysyl endopeptidases. The method was successfully employed to visualize intra-cellular histone modifying enzyme activity.
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Report
(4 results)
Research Products
(12 results)
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[Presentation]2010
Organizer
定量生物学の会第3回年会
Place of Presentation
東京大学生産技術研究所
Year and Date
2010-11-26
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