Functional and structural analyses of novel hybrid type polyketide synthase Steely
Project/Area Number |
20510196
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Hokkaido University |
Principal Investigator |
SAITO Tamao Hokkaido University, 理工学部, 准教授 (30281843)
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Co-Investigator(Kenkyū-buntansha) |
MORITA Naoki (独)産業技術総合研究所, 生物プロセス研究部門分子生物工学研究グループ, 研究グループ長 (60371085)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 二次代謝産物 / ポリケタイド合成酵素 / 細胞性粘菌 / ポリケタイド |
Research Abstract |
The soil microorganism, Dictyostelium, has novel hybrid-type polyketide synthase (PKS) known as 'Steely' ; Steely enzyme is formed by the fusion of type I and type III PKSs. In this study, we examined how these two different enzymes work together and what are the products of Steely enzymes. Finally, we examined the biological functions of these products.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Dictyostelium hybrid polyketide synthase, Steely A, produces 4-methyl-5-pentylbenzene-1,3-diol and induces spore maturation2011
Author(s)
Narita, TB., Koide, K., Morita, N., Saito, T.
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Journal Title
FEMS Microbiology Letters
Volume: (in press 未定)
Related Report
Peer Reviewed
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