Synthesis of functionalized artificial phospholipids for investigation of membrane related biosystems
| Project/Area Number |
20510202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto University |
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Principal Investigator |
FURUTA Takumi Kyoto University, 化学研究所, 准教授 (30336656)
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| Co-Investigator(Kenkyū-buntansha) |
KAN Toshiyuki 静岡県立大学, 薬学部, 教授 (10221904)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | リン脂質 / 生体膜 / 膜蛋白質 / 固相合成 / プローブ分子 / 加水分解 / アミド結合 / 蛍光プローブ |
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| Research Abstract |
A method for introduction of various head groups on phospholipid frameworks via oxime bond formation has been developed for the synthesis of cyclen?Cu (II), pyrene, naphthalene and other head group functionalized phospholipids. Furthermore, this synthetic method was expanded to a concise solid support synthesis of artificial phospholipids. The head group functionalized phospholipids, prepared in these synthetic studies, can cleave membrane protein, hemagglutinin.
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Report
(4 results)
Research Products
(97 results)
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[Journal Article] Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin.2010
Author(s)
T.Ishii, T.Mori, T.Ichikawa, M.Kaku, Y.Uekusa, M.Akagawa, Y.Aihara, T.Furuta, T.Wakimoto, T.Kan, T.Nakayama
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Journal Title
Bioorg. Med.Chem. 18
Pages: 4892-4896
Related Report
Peer Reviewed
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[Journal Article] Binding affinity of tea catechins for human serum albumin : Characterization by high-performance affinity chromatography with immobilized albumin column.2010
Author(s)
T.Ishii, K.Minoda, M.-J.Bae, T.Mori, Y.Uekusa, T.Ichikawa, Y.Aihara, T.Furuta, T.Wakimoto, T.Kan, T.Nakayama
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Journal Title
Mol.Nutr.Food Res. 54
Pages: 816-822
Related Report
Peer Reviewed
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[Journal Article] Identification and characterization of flavonoids as sialyltransferase inhibitors.2009
Author(s)
K.I.P.J.Hidari, K.Oyama,, G.Ito, M.Nakayama, M.Inai, S.Goto, Y.Kanai, K.Watanabe, K.Yoshida, T.Furuta, T.Kan, T.Suzuki
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Journal Title
Biochem. Biophys. Res.Commun.
Pages: 609-613
Related Report
Peer Reviewed
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[Journal Article] Synthesis and characteristic stereostructure of biphenanthryl ether.2008
Author(s)
Y.Koizumi, S.Suzuki, K.Takeda, K.Murahashi, M.Horikawa, K.Katagiri, H.Masu, T.Kato T, I.Azumaya, S.Fujii, T.Furuta, K.Tanaka, T.Kan
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Journal Title
Tetrahedron : Asymmetry 19
Pages: 1407-1410
Related Report
Peer Reviewed
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