Behavioral deficits in rats treated neonatally with an NMDA antagonist, a putative animal model of schizophrenia
| Project/Area Number |
20530664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Osaka City University |
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Principal Investigator |
KAWABE Kouichi Osaka City University, 大学院・文学研究科, 准教授 (30336797)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 作業記憶 / sensorimotor gating / NMDA受容体 / グルタミン酸神経系 / 認知障害 / 統合失調症 / 動物モデル / 生理心理学 / グルタミン酸 / カンナビノイドCB1受容体 |
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| Research Abstract |
Rats treated neonatally with an NMDA antagonist (MK-801), which are supposed as a putative animal model of schizophrenia, were tested for behavioral or cognitive deficits. Rats were treated with MK-801 from postnatal days 7 to 20. Sensorimotor gating and working memory was tested in adulthood, using prepulse inhibition (PPI) and spontaneous alternation (SA), respectively. As results, MK-801 induced a marginally significant impairment in PPI, but not in SA. MK-801 treatment in a short period (5 days) did not have any behavioral effects.
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Report
(4 results)
Research Products
(11 results)
