Mechanisms of functional differentiation in the Drosophila midgut
| Project/Area Number |
20570004
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Genetics/Genome dynamics
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
NAKAGOSHI Hideki Okayama University, 大学院・自然科学研究科, 准教授 (50314662)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | ショウジョウバエ / 腸管 / 機能分化 / 金属イオン / 酸 / アイソフォーム / 金属代謝 / 酸塩基平衡 / 細胞間情報伝達 / Rho GTPase / プロトンポンプ |
|---|
| Research Abstract |
The Drosophila middle midgut has two functions, copper absorption and acid secretion. These functions are established by intercellular communication between copper and interstitial cells. The transcription factor Dve has two isoforms (Dve-A, Dve-B), and the spatio-temporal regulation of isoform switching is cricial for functional differentiation of the midgut. In addition, the cell-type specific activities of Rho GTPase and V-ATPase are also required for the midgut functions.
|
Report
(4 results)
Research Products
(10 results)
