Mechanisms of functional differentiation in the Drosophila midgut

• Project/Area Number: 20570004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Genetics/Genome dynamics
• Research Institution: Okayama University
• Principal Investigator: NAKAGOSHI Hideki Okayama University, 大学院・自然科学研究科, 准教授 (50314662)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ショウジョウバエ / 腸管 / 機能分化 / 金属イオン / 酸 / アイソフォーム / 金属代謝 / 酸塩基平衡 / 細胞間情報伝達 / Rho GTPase / プロトンポンプ

Research Abstract

The Drosophila middle midgut has two functions, copper absorption and acid secretion. These functions are established by intercellular communication between copper and interstitial cells. The transcription factor Dve has two isoforms (Dve-A, Dve-B), and the spatio-temporal regulation of isoform switching is cricial for functional differentiation of the midgut. In addition, the cell-type specific activities of Rho GTPase and V-ATPase are also required for the midgut functions.

Research Products

• [Journal Article] Spatial and temporal requirement of Defective proventriculus activity during Drosophila midgut development (2011)
  • Author(s): Yoshiki Nakagawa, Shinobu Fujiwara-Fukuta, Takeshi Yorimitsu, Suzuka Tanaka, Ryunosuke Minami, Lily Shimooka, Hideki Nakagoshi
  • Journal Title: Mechanisms of Development vol.128,印刷中
  • Peer Reviewed
• [Journal Article] Spatial and temporal requirement of Defective proventriculus activity during Drosophila midgut development (2011)
  • Author(s): Yoshiki Nakagawa
  • Journal Title: Mechanisms of Development Volume: 128(印刷中)
  • Peer Reviewed
• [Presentation] ショウジョウバエ内胚葉におけるセプテートジャンクションの機能 (2010)
  • Author(s): 下岡リリー
  • Organizer: 日本分子生物学会第33回年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] ショウジョウバエ内胚葉におけるセプテートジャンクションの機能 (2010)
  • Author(s): 下岡リリー
  • Organizer: 日本分子生物学会第33回年会(神戸)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] ショウジョウバエDveの2種類のアイソフォームの時間空間的な要求性 (2009)
  • Author(s): 中川嘉規
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] ショウジョウバエdve遺伝子と遺伝的相互作用を示す新規因子の探索 (2009)
  • Author(s): 坂本豊仁
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Spatial and temporal requirement of Defective proventriculus activity during Drosophila midgut development (2009)
  • Author(s): 中越英樹
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: シカゴ(アメリカ合衆国)
  • Year and Date: 2009-03-05
• [Presentation] ショウジョウバエDveの機能ドメイン解析 (2008)
  • Author(s): 中越英樹
  • Organizer: 日本分子生物学会第31回年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Remarks] ホームページ等
  • URL: http://www.biol.okayama-u.ac.jp/nakagoshi/Kinou.html
• [Remarks]
  • URL: http://www.blol.okayama-u.ac.jp/nakagoshi/Kinou.html