A study on the molecular mechanisms of the functions of a peptide-gated Na^+ channel
Project/Area Number |
20570071
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Animal physiology/Animal behavior
|
Research Institution | Hiroshima University |
Principal Investigator |
FURUKAWA Yasuo Hiroshima University, 大学院・総合科学研究科, 教授 (40209169)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | イオンチャネル / ペプチド / 構造機能相関 |
Research Abstract |
Molecular aspects of the functions of a peptide-gated Na+ channel, FMRFamide-gated Na+ channel (FaNaC), were examined in this study. We found that the position 552 of FaNaC is involved in the activation and the desensitization of the channel, and that the negative electric charge on this position (Asp552) is essential for the inward rectification of the channel current.
|
Report
(4 results)
Research Products
(28 results)