Functional role of troponin, a muscle regulatory protein, in non-striated muscle
| Project/Area Number |
20570075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Teikyo Heisei University |
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Principal Investigator |
OBINATA Takashi Teikyo Heisei University, 現代ライフ学部, 非常勤講師 (40012413)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Naruki 千葉大学, 大学院・融合科学研究科, 講師 (40261896)
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| Research Collaborator |
SHOICHIRO Ono Emory University
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | トロポニン / Ca^<2+>-制御タンパク質 / 収縮運動 / 非横紋筋 / アクチン線維 / アクチン-ミオシン相互作用 / カルシウム制御タンパク質 / 非横紋筋細胞 / アクチン・ミオシン相互作用 / クマムシ / ホヤ / 線虫 / 産卵 / 運動のCa^<2+>-制御 / 筋上皮細胞 / 蛋白質 / 細胞・組織 / 生体分子 / 生理学 / 運動 |
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| Research Abstract |
Troponin has been known as a Ca2+-depedent regulator of muscle contraction characteristic of skeletal and cardiac muscles. In this investigation, we revealed the following. 1) Troponin also plays an essential role in contractile regulation of non-striated muscles such as smooth muscle and myoepithelial cells in ascidian, nematode, and tardigrade (water bear). 2) Troponin of vertebrate and amphioxus (cephalochordate) functions as a brake for muscle contraction in the absence of Ca^<2+>, while troponin in ascidian (urochordate) functions as Ca^<2+>-depedent accelerator for contraction. Based on the functional diversity and evolutionary comparison of troponin molecular structure, we suggest that divergence of troponin occurred during evolution of chordates.
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Report
(4 results)
Research Products
(22 results)
