Developmental mechanism of Drosophila male accessory gland analogous to mammalian prostate
| Project/Area Number |
20570202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Gakushuin University (2009-2013)
Kobe University (2008) |
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Principal Investigator |
ADACHI-YAMADA Takashi (ADACHI Takashi) 学習院大学, 理学部, 教授 (20221723)
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| Project Period (FY) |
2008-04-08 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | ショウジョウバエ / 附属腺/前立腺 / 二核細胞 / 繁殖戦略 / 立方/扁平上皮細胞 / 細胞周期制御 / 微小管結合因子 / Mad/NuMA / 附属腺 / 前立腺 / ２核化 / Mud / NuMA / 中央紡錘体 / 遺伝学 / 細胞・組織 / 発生・分化 / 細胞質分裂 / 発生 |
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| Research Abstract |
The accessory gland of adult male Drosophila is analogous to the mammalian prostate which produces various components in the seminal fluid. More than 80 kinds of peptidergic components are known to be important for male reproductive strategy in stimulation of various female reproductive behaviors. The accessory gland cells show a unique cellular feature in which all of the epithelial cells are binucleate cells. We demonstrated that this morphology brings a cell shape flexibility to cells to directly affect the volume of the accessory gland cavity and the storage amount of seminal fluid (Taniguchi et al. 2012). We also demonstrated that the cell cycle in the developing accessory gland was unusually synchronized around cytokinesis skipping in the pupal stage, a process of binucleation. Furthermore, we sought causal factor(s) to create binucleate cells. As a result, a previously unknown splicing variant of a microtubule–binding factor Mud/NuMA was responsible for this binucleation.
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Report
(7 results)
Research Products
(46 results)
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[Journal Article] The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila2012
Author(s)
Minami, R., Wakabayashi, M., Sugimori, S., Taniguchi, K., Kokuryo, A., Imano T., Adachi-Yamada T., Watanabe, N. and Nakagoshi, H.
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[Journal Article] Binucleation of Drosophila Adult Male Accessory Gland Cells Increases Plasticity of Organ Size for Effective Reproduction2011
Author(s)
Taniguchi, K., Kokuryo, A., Imano, T., Minami, R., Nakagoshi, H. and Adachi-Yamada, T.
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Journal Title
Related Report
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[Journal Article] RNAi-mediated knockdown showing impaired cell survival in Drosophila wing imaginal disc2009
Author(s)
Umemori, M., Habara, O., Iwata, T., Maeda, K., Nishinoue, K., Okabe, A., Takemura, M., Takahashi, K., Saigo, K., Ueda, R.Adachi-Yamada, T.
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Journal Title
Gene Regul.Syst.Biol 3
Pages: 11-20
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Peer Reviewed
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[Presentation] Cytokinesis-deficient binucleation of Drosophila accessory gland cells as a strategy for better reproductive success.2010
Author(s)
Taniguchi, K., Kokuryo, A., Imano, T., Minami, R., Nakagoshi, H., Adachi-Yamada, T.
Organizer
Joint Meeting of the SFBD and JSDB2010
Place of Presentation
フランス・パリ
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