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Study on the mechanisms by which functional foods regulate androgen receptor function

Research Project

Project/Area Number 20580141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionOsaka Prefecture University

Principal Investigator

YAMAJI Ryoichi  Osaka Prefecture University, 生命環境科学研究科, 准教授 (00244666)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアンドロゲン / アンドロゲン受容体 / 低酸素 / 低酸素誘導因子-1α / β-カテニン / バイオアッセイ / 食品成分 / 前立腺がん / β-catenin / 転写因子 / HIF-lα / 前立腺癌
Research Abstract

Androgen receptor regulates the expression of some genes involved in proliferation and progression of prostate cancer. In the present study, we identified hypoxia-inducible factor-1a (HIF-1a) and b-catenin as cooperative AR coactivators under hypoxic conditions and demonstrated the molecular mechanisms by which these coactivators enhanced AR transactivation. Furthermore, we constructed a rapid yeast bioassay for androgenic and anti-androgenic compounds based on the molecular mechanisms and analyzed anti-androgenic activity of food components.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (52 results)

All 2011 2010 2009 2008 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (29 results) Remarks (4 results)

  • [Journal Article] Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol : implication of DNA binding and acetylation of the receptor.2011

    • Author(s)
      Harada N, Atarashi K, Murata Y, Yamaji R, Nakano Y, Inui H
    • Journal Title

      J.Steroid.Biochem.Mol.Biol 123

      Pages: 65-70

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment.2011

    • Author(s)
      Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y, Inui H
    • Journal Title

      J.Steroid Biochem.Mol.Biol 123

      Pages: 58-64

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor.2010

    • Author(s)
      Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, Inui H
    • Journal Title

      Biosci.Biotech.Biochem 74

      Pages: 1965-1968

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive and convenient yeast reporter assay for high-throughput analysis by using a secretory luciferase from Cypridina noctiluca.2010

    • Author(s)
      Tochigi Y, Sato N, Sahara T, Wu C, Saito S, Irie T. Fujibuchi W, Goda T, Yamaji R, Ogawa M, Ohmiya Y, Ohgiya S.
    • Journal Title

      Anal.Chem 82

      Pages: 5768-5776

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of three glutamine tracts in human androgen receptor transactivation.2010

    • Author(s)
      Harada N., Mitani T, Higashimura Y, Yamaji R, Okamoto K, Nakano Y, Inui H
    • Journal Title

      J.Steroid Biochem.Mol.Biol 118

      Pages: 77-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor2010

    • Author(s)
      Masahiro Ogawa
    • Journal Title

      Biosci.Biotechnol.Biochem.

      Volume: 74 Pages: 1965-1968

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive and convenient yeast reporter assay for high-throughput analysis by using a secretory luciferase from Cypridina noctiluca2010

    • Author(s)
      Yuki Tochigi
    • Journal Title

      Anal.Chem.

      Volume: 82 Pages: 5768-5776

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-lalpha in a low androgen environment2010

    • Author(s)
      Takakazu Mitani
    • Journal Title

      J.Steroid Biochem.Mol.Biol.

      Volume: 123 Pages: 58-64

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol : Implication of DNA binding and acetylation of the receptor2010

    • Author(s)
      Naoki Harada
    • Journal Title

      J.Steroid Biochem.Mol.Biol.

      Volume: 123 Pages: 67-70

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of three glutamine tracts in human androgen receptor transactivation2010

    • Author(s)
      Naoki Harada
    • Journal Title

      J.Steroid Biochem.Mol.Biol. 118

      Pages: 77-84

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis.2009

    • Author(s)
      Kawasaki T, Igarashi K, Koeda T, Sugimoto K, Nakagawa K, Hayashi S, Yamaj R, Yamaj R, Fukusato T, Yamanouchi T
    • Journal Title

      J.Nutr 139

      Pages: 2067-2071

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitive effects of alkyl gallates on hyaluronidase and collagenase2009

    • Author(s)
      Florin Barla
    • Journal Title

      Biosci.Biotechnol.Biochem. 73

      Pages: 2335-2337

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis.2009

    • Author(s)
      Takahiro Kawasaki
    • Journal Title

      J.Nutr. 139

      Pages: 2067-2071

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation.2008

    • Author(s)
      Ishii T, Mori T, Tanaka T, Mizuno D, Yamaj R, Kumazawa S, Nakayama T, Akagawa M.
    • Journal Title

      Free Radic Biol Med 45

      Pages: 1384-1394

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Moonlighting タンパク質として見直され るGAPDH の機能~アンドロゲン受容体 の転写活性におけるコアクチベーターと しての役割~2008

    • Author(s)
      原田直樹, 山地亮一, 乾博
    • Journal Title

      化学と生物 46

      Pages: 817-819

    • NAID

      10024938849

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ARA24/Ran enhances the androgen-dependent NH_<2-> and COOH-terminal interaction of the androgen receptor.2008

    • Author(s)
      Harada N, Ohmori Y, Yamaj R, Higashimura Y, Okamoto K, Isohashi F, Nakano Y, Inui H
    • Journal Title

      Biochem Biophys Res Commun 373

      Pages: 373-377

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ARA24/Ran enhances the androgen-dependent NH_2- and COOH-terminal interaction of the androgen receptor2008

    • Author(s)
      Naoki HARADA
    • Journal Title

      Biochem. Biophys. Res. Commun. 373

      Pages: 373-377

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moonlightingタンパク質として見直されるGAPDHの機能〜アンドロゲン受容体の転写活性におけるコアクチベーターとしての役割〜2008

    • Author(s)
      原田直樹
    • Journal Title

      化学と生物 46

      Pages: 817-819

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation2008

    • Author(s)
      Takeshi Ishii
    • Journal Title

      Free Radic. Biol. Med. 45

      Pages: 1384-1394

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] アンドロゲン受容体の低酸素による分解亢進について2011

    • Author(s)
      三谷塁一
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 前立腺がん進行における短鎖型アンドロゲン受容体の機能とレスベラトロールの作用について2011

    • Author(s)
      原田直樹
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Hypoxia-inducible factor(HIF)-1α enhances the transcriptionalactivity2010

    • Author(s)
      三谷塁一
    • Organizer
      日生化学会・分子生物学会合同年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 前立腺がん細胞における短鎖型アンドロゲン受容体の産生機構について2010

    • Author(s)
      井上薫
    • Organizer
      日生化学会・分子生物学会合同年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Hypoxia-inducible factor (HIF)-1α enhances the transcriptional activity of_androgen receptor without HIF-1 activity in hypoxia.2010

    • Author(s)
      三谷塁一
    • Organizer
      日生化学会・分子生物学会合同年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前立腺がんにおける短鎖型アンドロゲン受容体の役割2010

    • Author(s)
      井上薫
    • Organizer
      日本農芸化学会関西支部第466回講演会
    • Place of Presentation
      近畿大学(奈良県)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] アンドロゲン受容体のアセチル化を介したレスベラトロールの作用2010

    • Author(s)
      原田直樹
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      アクティとくしま(徳島県)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 低酸素によるアンドロゲン受容体シグナルの亢進2010

    • Author(s)
      三谷塁一
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] レスベラトロールはアンドロゲン受容体のアセチル下を減少させる2010

    • Author(s)
      原田直樹
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 酵母を用いた抗アンドロゲン物質スクリーニングシステムの構築,日本農芸化学関西・中四国・西日本支部合同沖縄大会, レスベラトロールによる核内AR の減少について2009

    • Author(s)
      小川真弘
    • Organizer
      日本栄養食糧学会近畿支部
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2009-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] レスベラトロールによる核内ARの減少について2009

    • Author(s)
      新清孝
    • Organizer
      日本栄養食糧学会近畿支部
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酵母を用いた抗アンドロゲン物質スクリーニングシステムの構築2009

    • Author(s)
      小川真弘
    • Organizer
      日本農芸化学関西・中四国・西日本支部合同沖縄大会
    • Place of Presentation
      琉球大学(沖縄県)
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素誘導因子-2αはグルココルチコイドシグナルを活性化する2009

    • Author(s)
      東村泰希
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 低酸素シグナルによるアンドロゲン受容体シグナルの調節2009

    • Author(s)
      三谷塁一
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒトアンドロゲン受容体の転写を調節する3つのポリグルタミン領域について2009

    • Author(s)
      原田直樹
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] MoonlightingProtein による多機能調節:アンドロゲン受容体シグナルにおけるGAPDHの役割2009

    • Author(s)
      山地亮一
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)招待講演
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] (招待講演)Moonlighting Proteinによる多機能調節:アンドロゲン受容体シグナルにおけるGAPDHの役割2009

    • Author(s)
      山地亮一
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Daidzein attenuates the HIF-2α expression in human cervix adenocarcinoma cells2009

    • Author(s)
      東村泰希
    • Organizer
      第19回国際栄養学会議
    • Place of Presentation
      バンコック国際貿易展示センター(タイ)
    • Year and Date
      2009-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Resveratrol inhibits nuclear accumulation of androgen receptor2009

    • Author(s)
      原田直樹
    • Organizer
      第19回国際栄養学会議
    • Place of Presentation
      バンコック国際貿易展示センター(タイ)
    • Year and Date
      2009-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Daidzein attenuates the HIF-2α expression in human cervix adenocarcinoma cells2009

    • Author(s)
      Yasuki Higashimura
    • Organizer
      第19回国際栄養学会議
    • Place of Presentation
      バンコック国際貿易展示センター(タイ国バンコック市)
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Resveratrol inhibits nuclear accumulation of androgen receptor2009

    • Author(s)
      Naoki Harada
    • Organizer
      第19回国際栄群会議
    • Place of Presentation
      バンコック国際貿易展示センター(タイ国バンコック市)
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 前立腺がん細胞におけるアンドロゲン受容体シグナルと低酸素シグナルのクロストーク2009

    • Author(s)
      三谷塁一
    • Organizer
      農芸化学会関西支部例会
    • Place of Presentation
      大阪府立大学(大阪府)
    • Year and Date
      2009-07-04
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] アンドロゲンシグナルに及ぼすレスベラトロールの作用2009

    • Author(s)
      原田直樹
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] HIF-1αとβ-catenin によるアンドロゲン受容体シグナル調節機構の解析2008

    • Author(s)
      三谷塁一
    • Organizer
      生化学会・分子生物学会合同年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2008-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] HIF-1αとβ-cateninによるアンドロゲン受容体シグナル調節機構の解析2008

    • Author(s)
      三谷塁一
    • Organizer
      生化学会・分子生物学会合同年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低酸素誘導因子-1αはアンドロゲン受容体シグナルを調節する2008

    • Author(s)
      三谷塁一
    • Organizer
      日本農芸化学会関西支部大会
    • Place of Presentation
      京都学園大学(京都府)
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 低酸素誘導因子-1αはアンドロゲン受容体シグナルを調節する2008

    • Author(s)
      三谷塁一
    • Organizer
      日本農芸化学会関西支部大会
    • Place of Presentation
      京都学園大学
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] アンドロゲン受容体シグナルの関与する性差疾患:分子機構の解明と食による予防を目指して2008

    • Author(s)
      山地亮一
    • Organizer
      日本農芸化学会関西支部例会
    • Place of Presentation
      大阪府立大学(大阪府)
    • Year and Date
      2008-07-12
    • Related Report
      2010 Final Research Report
  • [Presentation] アンドロゲン受容体シグナルの関与する性差疾患 - 分子機構の解明と食による予防を目指して-2008

    • Author(s)
      山地亮一
    • Organizer
      日本農芸化学会関西支部例会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.biochem.osakafu-u.ac.jp/NC/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.biochem.osakafu-u.ac.jp/NC/Researc.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.biochem.osakafu-u.ac.jp/NC/Researc.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.biochem.osakafu-u.ac.jp/NC/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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