| Project/Area Number |
20580318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAMOTO Yukio Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 (40321707)
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| Co-Investigator(Kenkyū-buntansha) |
亀井 康富 東京医科歯科大学, 難治疾患研究所, 准教授 (70300829)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エストロゲン / エストロゲンレセプター / 脂質代謝 / 核内受容体 / クロストーク / 転写調節 / 生活習慣病 / CAR |
|---|
| Research Abstract |
The underlying molecular mechanism of the sex difference in lipid metabolism remains largely unknown. We investigate the roles of hepatic nuclear receptors : ERα (Estrogen Receptor α), which is an authentic estrogen receptor, and LXR (Liver X Receptor) and CAR(Constitutive Androstane/Active Receptor), which are regulators of hepatic lipid metabolism. The transcriptional crosstalk between LXR, CAR, and ERα may explain the suppression mechanism of lipid synthesis by estrogens.
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