Regulatory mechanisms for the proliferation and invasion under oxidative stress via modulation of membranous glycolipids.
| Project/Area Number |
20580369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MIURA Yutaka Tokyo University of Agriculture and Technology, 大学院・農学研究院, 准教授 (10219595)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 癌細胞浸潤 / 酸化ストレス / 細胞膜糖脂質 / ガングリオシド / 癌細胞増殖 / 糖脂質 / 細胞膜 / 癌転移 |
|---|
| Research Abstract |
The regulatory mechanisms for the protentiation of mouse melanoma cell invasion under hypoxic condition were investigated. The increase in membranous ganglioside GM3 contents and the modulation of proteins-glycolipids complex in cell membrane were proved to be deeply involved in this phenomenon. This result indicates novel mechanisms for cancer aggravation under hypoxia.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage.2009
Author(s)
Fujiyama-Nakamura S, Yoshikawa H, Homma K, Hayano T, Tsujimura, Takahashi T, Izumikawa K, Ishikawa H, Miyazawa N, Yanagida M, Miura Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N.
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Journal Title
Molecular and Cellular Proteomics 8
Pages: 1552-1565
Related Report
Peer Reviewed
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