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Studies on the Bioactivity and Intensive Use of the Constituents of Azadirachta indica (Neem)

Research Project

Project/Area Number 20590015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionNihon University

Principal Investigator

AKIHISA Toshihiro  Nihon University, 理工学部, 教授 (30060213)

Co-Investigator(Renkei-kenkyūsha) SUZUKI Takashi  日本大学, 薬学部, 教授 (40318457)
YASUKAWA Ken  日本大学, 薬学部, 教授 (00130625)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsニーム / リモノイド / メラニン産生抑制 / 抗腫瘍活性 / 発がん予防効果
Research Abstract

Thirty-one limonoids and one diterpenoid, and seventeen limonoids were isolated from the methanol and hexane extracts, respectively, of neem seeds. Among these compounds, seven were new compounds, and their structures were determined spectroscopically. These compounds were evaluated for their melanogenesis-inhibitory, anti-inflammatory, Epstein-Barr virus early antigen (EBV-EA) activation inhibitory, and cytotoxic activities. Some of these compounds have been revealed to possess potent melanogenesis-inhibitory, anti-inflammatory, EBV-EA activation inhibitory, and cytotoxic activities with apoptosis induction.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (19 results)

  • [Journal Article] Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem)2011

    • Author(s)
      Takashi Kikuchi, Koichi Ishii, Taisuke Noto, Akitomo Takahashi, Keiichi Tabata, Takashi Suzuki, Toshihiro Akihisa
    • Journal Title

      Journal of Natural Products 74巻

      Pages: 866-870

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The melanogenesis-inhibitory, antiinflammatory, and chemopreventive effects of limonoids from n-hexane extract of Azadirachta indica A.Juss. (neem) seeds2011

    • Author(s)
      Toshihiro Akihisa, Akitomo Takahashi, Takashi Kikuchi, Mio Takagi, Kensuke Watanabe, Makoto Fukatsu, Yukiko Fujita, Norihiro Banno, Harukuni Tokuda, Ken Yasukawa
    • Journal Title

      Journal of Oleo Science 60巻

      Pages: 53-59

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Melanogenesis-Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids in n-Hexane Extract of Azadirachta indica A.Juss.(Neem) Seeds2011

    • Author(s)
      秋久俊博
    • Journal Title

      Journal of Oleo Science

      Volume: 60 Pages: 53-59

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic and Apoptosis-Inducing Activities of Limonoids from the Seeds of Azadirachta indica (Neem)2011

    • Author(s)
      秋久俊博
    • Journal Title

      Journal of Natural Products

      Volume: 74(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indica A.Juss. (neem)2009

    • Author(s)
      Toshihiro Akihisa, Taisuke Noto, Akitomo Tkahashi, Yukiko Fujita, Norihiro Banno, Harukuni Tokuda, Kazuo Koike, Takashi Suzuki, Ken Yasukawa, Yumimko Kimura
    • Journal Title

      Journal of Oleo Science 58巻

      Pages: 581-594

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indica A.Juss.(Neem)2009

    • Author(s)
      秋久俊博
    • Journal Title

      Journal of Oleo Science 58

      Pages: 581-594

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cytotoxic and apoptosis -inducing activities of limonoids from the seed extract of Azadirachta indica A.Juss. (neem)2011

    • Author(s)
      Takashi Kikuchi, Koichi Ishii, Taisuke Noto, Akitomo Takahashi, Keiichi Tabata, Takashi Suzuki, Toshihiro Akihisa
    • Organizer
      The 3rd International Conference on Natural Products for Health and Beauty (3rd NATPRO)
    • Place of Presentation
      The Emerald Hotel Bangkok
    • Year and Date
      2011-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Cytotoxic and Apoptosis-Inducing Activities of Limonoids from the Seed Extract of Azadirachta indica A.Juss. (Neem)2011

    • Author(s)
      菊地崇
    • Organizer
      The 3rd International Conference on Natural Products for Health and Beauty
    • Place of Presentation
      The Emerald Hotel Bangkok, Thai
    • Year and Date
      2011-03-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニーム種子ヘキサン抽出物由来リモノイド成分の生物活性2010

    • Author(s)
      渡邊賢介,高橋章友,菊地崇,高木美緒,秋久俊博,深津誠,藤田幸子,伴野規博,徳田春邦,安川憲
    • Organizer
      日本生薬学会第57回年会
    • Place of Presentation
      徳島文理大学
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム種子ヘキサン抽出物由来リモノイド成分の生物活性2010

    • Author(s)
      渡邊賢介
    • Organizer
      日本生薬学会 第57回年会
    • Place of Presentation
      徳島文理大学
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニーム葉部リモノイド成分の細胞傷害活性2009

    • Author(s)
      高木美緒,高橋章友,石井孝一,菊地崇,伴野規博,鈴木孝, 秋久俊博
    • Organizer
      第53回日本大学理工学部学術講演会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム種子由来リモノイド類化合物の細胞傷害活性及びメラニン産生抑制活性2009

    • Author(s)
      高橋章友,菊地崇,渡邊賢介,伴野規博,深津誠,田畑恵市,鈴木孝,秋久俊博
    • Organizer
      第53回日本大学理工学部学術講演会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム種子由来リモノイド類化合物の細胞傷害活性及びメラニン産生抑制活性2009

    • Author(s)
      高橋章友
    • Organizer
      第53回理工学部学術講演会
    • Place of Presentation
      日本大学理工学部駿河台校舎
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニーム葉部リモノイド成分の細胞傷害活性2009

    • Author(s)
      高木美緒
    • Organizer
      第53回理工学部学術講演会
    • Place of Presentation
      日本大学理工学部駿河台校舎
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニーム種子由来リモノイド化合物のアポトーシス誘導活性2009

    • Author(s)
      石井孝一,能登泰輔,二瓶雅俊,高橋章友,高木美緒,秋久俊博,田畑恵市,鈴木孝
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都薬科大学
    • Year and Date
      2009-10-04
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ニーム葉部リモノイド成分の細胞傷害および抗炎症活性,ならびにEBV 活性化抑制効果2009

    • Author(s)
      高木美緒,秋久俊博,高橋章友,石井孝一,菊地崇,伴野規博,安川憲,徳田春邦
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム葉部リモノイド成分の細胞傷害および抗炎症活性, ならびにEBV活性化抑制効果2009

    • Author(s)
      高木 美緒
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニーム種子抽出物不ケン化脂質の新規ノルトリテルペノイド成分2008

    • Author(s)
      高橋章友,秋久俊博,能登泰輔,菊地崇,伴野規博,藤田幸子,鈴木孝,安川憲,木村由美子
    • Organizer
      第52回日本大学理工学部学術講演会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2008-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム葉部リモノイド成分の単離および細胞傷害活性2008

    • Author(s)
      高木美緒,秋久俊博,高橋章友,石井孝一,菊地崇,伴野規博,孫奕,安川憲,木村由美子
    • Organizer
      第52回日本大学理工学部学術講演会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2008-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム葉部リモノイド成分の単離および細胞傷害活性2008

    • Author(s)
      高木 美緒
    • Organizer
      第52回理工学部学術講演会
    • Place of Presentation
      日本大学理工学部駿河台校舎
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニーム種子抽出物不ケン化脂質の新規ノルトリテルペノイド成分2008

    • Author(s)
      高橋 章友
    • Organizer
      第52回理工学部学術講演会
    • Place of Presentation
      日本大学理工学部駿河台校舎
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニーム葉部のリモノイド成分2008

    • Author(s)
      高木美緒,高橋章友,能登泰輔,秋久俊博,孫奕,安川憲,木村由美子
    • Organizer
      日本油化学会第47回年会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2008-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム種子由来成分のメラニン産生抑制活性2008

    • Author(s)
      高橋章友,秋久俊博,能登泰輔,伴野規博,藤田幸子,鈴木孝,木村由美子
    • Organizer
      日本油化学会第47回年会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2008-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] ニーム種子由来成分のメラニン産生抑制活性2008

    • Author(s)
      高橋 章友
    • Organizer
      日本油化学会第47回年会
    • Place of Presentation
      日本大学理工学部駿河台キャンパス
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニーム葉部リモノイド成分の細胞傷害および抗炎症活性, ならぴにEBV活性化抑制効果2008

    • Author(s)
      高木 美緒
    • Organizer
      日本油化学会第47回年会
    • Place of Presentation
      日本大学理工学部駿河台キャンパス
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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