| Project/Area Number |
20590015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Nihon University |
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Principal Investigator |
AKIHISA Toshihiro Nihon University, 理工学部, 教授 (30060213)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Takashi 日本大学, 薬学部, 教授 (40318457)
YASUKAWA Ken 日本大学, 薬学部, 教授 (00130625)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ニーム / リモノイド / メラニン産生抑制 / 抗腫瘍活性 / 発がん予防効果 |
|---|
| Research Abstract |
Thirty-one limonoids and one diterpenoid, and seventeen limonoids were isolated from the methanol and hexane extracts, respectively, of neem seeds. Among these compounds, seven were new compounds, and their structures were determined spectroscopically. These compounds were evaluated for their melanogenesis-inhibitory, anti-inflammatory, Epstein-Barr virus early antigen (EBV-EA) activation inhibitory, and cytotoxic activities. Some of these compounds have been revealed to possess potent melanogenesis-inhibitory, anti-inflammatory, EBV-EA activation inhibitory, and cytotoxic activities with apoptosis induction.
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