Studies on the Bioactivity and Intensive Use of the Constituents of Azadirachta indica (Neem)
Project/Area Number |
20590015
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
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Research Institution | Nihon University |
Principal Investigator |
AKIHISA Toshihiro Nihon University, 理工学部, 教授 (30060213)
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Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Takashi 日本大学, 薬学部, 教授 (40318457)
YASUKAWA Ken 日本大学, 薬学部, 教授 (00130625)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ニーム / リモノイド / メラニン産生抑制 / 抗腫瘍活性 / 発がん予防効果 |
Research Abstract |
Thirty-one limonoids and one diterpenoid, and seventeen limonoids were isolated from the methanol and hexane extracts, respectively, of neem seeds. Among these compounds, seven were new compounds, and their structures were determined spectroscopically. These compounds were evaluated for their melanogenesis-inhibitory, anti-inflammatory, Epstein-Barr virus early antigen (EBV-EA) activation inhibitory, and cytotoxic activities. Some of these compounds have been revealed to possess potent melanogenesis-inhibitory, anti-inflammatory, EBV-EA activation inhibitory, and cytotoxic activities with apoptosis induction.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] The melanogenesis-inhibitory, antiinflammatory, and chemopreventive effects of limonoids from n-hexane extract of Azadirachta indica A.Juss. (neem) seeds2011
Author(s)
Toshihiro Akihisa, Akitomo Takahashi, Takashi Kikuchi, Mio Takagi, Kensuke Watanabe, Makoto Fukatsu, Yukiko Fujita, Norihiro Banno, Harukuni Tokuda, Ken Yasukawa
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Journal Title
Journal of Oleo Science 60巻
Pages: 53-59
Related Report
Peer Reviewed
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[Journal Article] Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indica A.Juss. (neem)2009
Author(s)
Toshihiro Akihisa, Taisuke Noto, Akitomo Tkahashi, Yukiko Fujita, Norihiro Banno, Harukuni Tokuda, Kazuo Koike, Takashi Suzuki, Ken Yasukawa, Yumimko Kimura
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Journal Title
Journal of Oleo Science 58巻
Pages: 581-594
Related Report
Peer Reviewed
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[Presentation] ニーム葉部のリモノイド成分2008
Author(s)
高木美緒,高橋章友,能登泰輔,秋久俊博,孫奕,安川憲,木村由美子
Organizer
日本油化学会第47回年会
Place of Presentation
日本大学理工学部
Year and Date
2008-09-17
Related Report
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