Development and application of novel environmental harmonized tandem reaction catalyzed by typical metal salt
| Project/Area Number |
20590027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hiroshima International University |
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Principal Investigator |
YANADA Reiko Hiroshima International University, 薬学部, 教授 (80239821)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 金属塩 / 触媒反応 / 環境調和型 / タンデム反応 / 2-アルキニルベンズアミド / 超原子価ヨウ素試薬 / ホフマン型転位 / イソシアネート / 金属塩触媒 / ホフマン転位 / 合成化学 / パラジウム / インジウム / 薗頭反応 |
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| Research Abstract |
Starting from 2-alkynylbenzaldehydes and 2-alkynylanilines, In(OTf)3-catalyzed synthesis of ring-condensed heteroaromatic compounds was developed via a domino intramolecular nucleophilic attack/intermolecular cycloaddition/dehydration reaction. And a concise one-pot synthesis of indoles and isoquinolines from isocyanates which are derived from a Hofmann-type rearrangement of amides using a hypervalent iodine reagent was also developed.
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Report
(4 results)
Research Products
(37 results)
