| Project/Area Number |
20590042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
MORISHITA Mariko Hoshi University, 薬学部, 准教授 (70257096)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYAMA Kozo 星薬科大学, 薬学部, 教授 (00130758)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物送達システム / インスリン / バイオ医薬 / 細胞膜透過ペプチド / バイオアベイラビリティ / 機能性ペプチド / 吸収改善 / Caco-2細胞 |
|---|
| Research Abstract |
The purpose of this study was to investigate the safety and usefulness of functional peptides, which are expected as new tools to improve the bioavailability of oral and nasal administration of biologics, and was to clarify the mechanism of their absorption enhancement action. In addition, these functional peptides were incorporated to new carriers, such as smart hydrogels and the reverse-type micelle nanoparticles, and their usefulness were investigated in the in vivo study. As a result, we found that safety and efficacy of the functional peptide is significantly high, and good compatibility with the delivery carrier was shown. Therefore, this study demonstrated that high possibility of developing a non-invasive delivery system using functional peptides, and the delivery system can be applied to various biologics.
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