| Project/Area Number |
20590047
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Mukogawa Women's University |
|---|
Principal Investigator |
MATSUNAGA Hisami Mukogawa Women's University, 薬学部, 准教授 (70271418)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAGINAKA Jun 武庫川女子大学, 薬学部, 教授 (20164759)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | メタボリックシンドローム / リン酸化合物 / 血漿 / メタボローム解析 / リン酸化プロテオーム / モノリスカラム / 分子インプリントポリマー / リン酸化ペプチド |
|---|
| Research Abstract |
We thought that we were available to the metabolic syndrome model rat which had a lifestyle-related disease in what we cast a metabonomics analysis into if we could confirm that a metabolism thing changed from a steady state by analyzing living body samples such as urine or the plasma. Therefore we squeezed a target to a phosphate compound and prepared molecular polymer (MIP) to imprint to catch a phosphate compound. we applied to the specific recognition of the phosphate compound to MIP and used it for fixed-quantity by extracting a target molecule selectively. These results suggest that in addition to their shape recognition, hydrogen bonding interactions could play an important role in retentivity and molecular recognition ability of derivatives of phosphoric acid. Furthermore, the MIPs could be successfully applied to specific recognition of phosphopeptides.
|
