| Project/Area Number |
20590084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISOHAMA Yoichiro Kumamoto University, 大学院・生命科学研究部, 准教授 (10240920)
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| Co-Investigator(Renkei-kenkyūsha) |
HISATSUNE Akinori 熊本大学, 大学院・生命科学研究部, 助教 (50347001)
KATSUKI Hiroshi 熊本大学, 大学院・生命科学研究部, 教授 (40240733)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肺胞上皮細胞 / アクアポリン / 転写因子Sp3 / 肺上皮細胞 / 転写因子 / 細胞分化 / アクアポリ / 肺気腫 / Sp3転写因子 / 肺胞II型上皮細胞 / Sp3 / 分化 |
|---|
| Research Abstract |
In this study, we examined the role of Sp3 in alveolar cells, during differentiation. We have found that Sp3 is expressed in alveolar type II cells and mesenchymal cells, but not in type I cells, and that overexpression of Sp3 considerably increased mRNA expression of an enzyme, which is important to synthesis pulmonary surfactant. In addition, Sp3 may be involved in IL-6- and STAT3-dependent gene expression. Further, expression of Sp3 and aquaporin-3 was decreased by TNF-alpha, through the activation of ERK and CEBP.
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