Progression of atherosclerosis in hypertriglyceridemic rabbit
| Project/Area Number |
20590087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Yamagata University (2009-2010)
Ohu University (2008) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATANO Yumi 山形大学, 医学部, 名誉教授 (70018696)
ITOH Tsunekata 山形大学, 医学部, 助手 (80241719)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | トリグリセリド / 動脈硬化 / ウサギ / 血管 / PHTウサギ / メタボリックシンドローム / PHT / 内皮依存性弛緩 / 加齢 / リポタンパク / インスリン抵抗性 |
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| Research Abstract |
Postprandial hypertriglyceridemic rabbits (PHT) showed vascular endothelial dysfunction. The vascular reactivity to angiotensin and urotensin was not significantly different. The lipid peroxidation was increased in plasma and visceral fat of PHT rabbits. The accumulation of peroxynitrite could be responsible for endothelial injury and atherosclerosis.
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Report
(4 results)
Research Products
(25 results)
