Development of novel class of Cdc25A inhibitor by combination of hydrophilic and hydrophobic group
Project/Area Number |
20590110
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Drug development chemistry
|
Research Institution | Tohoku University |
Principal Investigator |
SHIMAZAWA Rumiko Tohoku University, 大学院・医歯薬学総合研究科, 准教授 (00411083)
|
Co-Investigator(Kenkyū-buntansha) |
KURIYAMA Masami 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (40411087)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 脱リン酸化酵素 / Cdc25A / 複素環 / 付加反応 / 触媒的付加 / フタライド |
Research Abstract |
Novel N-heterocyclic derivatives were designed and synthesized as a Cdc25A inhibitor. The N-heterocyclic derivatives which have long alkyl chains exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A. In addition, efficient synthesis of 3-arylphthalides via palladium-catalyzed 1,2-addition with the novel thioether-imidazolinium carbene ligands was successfully achieved.
|
Report
(4 results)
Research Products
(21 results)