Analysis for individual difference in xenobiotic metabolism
| Project/Area Number |
20590121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
HANIOKA Nobumitsu Okayama University, 大学院・医歯薬学総合研究科, 准教授 (70228518)
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| Co-Investigator(Kenkyū-buntansha) |
NARIMATSU Shizuo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (20113037)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 環境化学物質 / 異物代謝酵素 / シトクロムP450(CYP) / UDP-グルクロン酸転移酵素(UGT) / 遺伝子多型 / 個別化危険度評価 / 個別危険度評価 / シトクロムP450 / CYP2E1 / UDP-グルクロン酸転移酵素 / 核内受容体 / 環境的要因 / 遺伝的要因 |
|---|
| Research Abstract |
The purpose of this study was to clarify whether the genetic polymorphism of CYP2E1 affect the metabolism of environmental chemicals. The findings obtained may mean that the polymorphic alleles of CYP2E1 causing amino acid substitutions are not directly associated with the metabolic activation of benzene and toluene.
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Report
(4 results)
Research Products
(20 results)
