Functional characterization of drug metabolizing enzyme genes and variant proteins
Project/Area Number |
20590154
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Tohoku University |
Principal Investigator |
HIRATSUKA Masahiro Tohoku University, 大学院・薬学研究科, 准教授 (50282140)
|
Co-Investigator(Kenkyū-buntansha) |
佐々木 崇光 東北薬科大学, 薬学部, 助手 (20382674)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | ゲノム / 酵素 / 薬剤反応性 / 遺伝子 / 蛋白質 |
Research Abstract |
Drug metabolizing enzymes, CYP2D6, CYP2B6, and TPMT are enzymes of potential importance for the metabolism of clinically used drugs, and it exhibits genetic polymorphism with interindividual differences in metabolic activity. The aim of this study was to investigate the functional characterization of CYP2D6, CYP2B6, and TPMT variants. Functional characterization of 17 CYP2D6, 26 CYP2B6, and 23 TPMT variants revealed an altered enzyme activity of a number of allelic variants.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.2009
Author(s)
Mutsumi Kudo, Yuka Saito, Takamitsu Sasaki, Hitomi Akasaki, Yuri Yamaguchi, Moe Uehara, Kiyomi Fujikawa, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka.
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Journal Title
Drug Metab. Pharmacokinet. 24
Pages: 557-564
NAID
Related Report
Peer Reviewed
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[Journal Article] Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).2008
Author(s)
Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka.
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Journal Title
Drug Metab. Dispos. 36
Pages: 2460-2467
Related Report
Peer Reviewed
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[Journal Article] Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57)2008
Author(s)
作山佳奈子、平塚真弘, ら
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Journal Title
Drug Metabolism and Disposition 36
Pages: 2460-2467
Related Report
Peer Reviewed
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