| Project/Area Number |
20590183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gunma University |
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Principal Investigator |
YORIFUJI Hiroshi Gunma University, 大学院・医学系研究科, 教授 (00158544)
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| Co-Investigator(Kenkyū-buntansha) |
TAJIKA Yuki 群馬大学, 大学院・医学系研究科, 助教 (90400738)
SATO Mahito 群馬大学, 大学院・医学系研究科, 講師 (60375532)
UENO Hitoshi 群馬大学, 大学院・医学系研究科, 助教 (30586251)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 骨格筋 / 機能分子 / 小胞融合関連蛋白 / 細胞膜-細胞骨格連関 / 分子細胞生物学 |
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| Research Abstract |
Sarcolemma is exposed to tensile strength when skeletal muscle fiber contracts and it sometimes makes tears in sarcolemma. The repair is carried out by the fusion of vesicles. But the origin of the vesicles for repair is not known. We studied VAMPs (vesicle associated membrane proteins) in skeletal muscles and found that VAMP2 is a unique marker for muscle differentiation and VAMP5 works in mature muscle fibers. In addition, we studied the functions of beta-synemin in skeletal muscles in vivo which is not only a constituent of intermediate filaments but also a link molecule between the filaments and sarcolemma. We found that beta-synemin is not necessary for muscle development and maintenance under usual breeding condition as well as moderate exercise loading.
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