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Identification of novel genes involving in the cell-division of neural progenitor cells.

Research Project

Project/Area Number 20590196
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionDokkyo Medical University

Principal Investigator

NAKADATE Kazuhiko  Dokkyo Medical University, 医学部, 准教授 (80372895)

Co-Investigator(Kenkyū-buntansha) 大桃 秀樹  獨協医科大学, 医学部, 助教 (90453406)
榊原 伸一  早稲田大学, 人間科学学術院, 教授 (70337369)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細胞・組織 / 再生医学 / 脳・神経 / 発生・分化 / 神経科学 / 中枢神経系 / 幹細胞 / 遺伝子 / 細胞死
Research Abstract

(No Summary)

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (24 results)

  • [Journal Article] Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through post-transcriptional regulation of Robo3/Rig-1 expression.2010

    • Author(s)
      Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, Tessier-Lavigne M, OkanoHJ, Okano H.
    • Journal Title

      Neuron 67

      Pages: 407-421

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improved learning in microencephalic rats.2010

    • Author(s)
      Ueda S, Yoshimoto K, Kadowaki T, Hirata K, Sakakibara S.
    • Journal Title

      Congenit.Anom 50

      Pages: 58-63

    • NAID

      10029577548

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小胞性グルタミン酸トランスポーター2010

    • Author(s)
      久野節二, 伊奈鮎香, 吉田さちね, 大桃秀樹, 川野道宏
    • Journal Title

      生体の科学 61(5)

      Pages: 400-401

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of 5-HT fibers in hippocampal heterotopia of methylazoxymethanol-induced micrencephalic rats after neonatal 5, 7-DHT injection.2010

    • Author(s)
      Nakamura A, Kadowaki T, Sakakibara S, Yoshimoto K, Hirata K, Ueda S.
    • Journal Title

      Anat.Sci.Int 85

      Pages: 38-45

    • NAID

      10027191167

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural RNA-binding protein Musashil controls midline crossing of prece rebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression.2010

    • Author(s)
      Kuwako K
    • Journal Title

      Neuron

      Volume: 67(3) Pages: 407-421

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved learning in microencephalic rats.2010

    • Author(s)
      Ueda S
    • Journal Title

      Congenit.Anom.

      Volume: 50(1) Pages: 58-63

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of 5-HT fibers in hippocampal heterotopia of methylazoxy methanol-induced micrencephalic rats after neonatal 5,7-DHT injection.2010

    • Author(s)
      Nakamura A
    • Journal Title

      Anat.Sci.Int.

      Volume: 85(1) Pages: 38-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal changes in expression of vesicular glutamate transporters in the main olfactory bulb of the rat.2009

    • Author(s)
      Ohmomo H, Ina A, Yoshida S, Shutoh F, Ueda S, Hisano S
    • Journal Title

      Neuroscience 160

      Pages: 419-426

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal changes in expression of vesicular glutamate transporters in the main olfactory bulb of the rat2009

    • Author(s)
      大桃秀樹, 他
    • Journal Title

      Neuroscience 160(2)

      Pages: 416-426

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat : implications of macrophage/microglial activation in the pathogenesis.2008

    • Author(s)
      Sakakibara S, Nakadate K, Ookawara S, Ueda S.
    • Journal Title

      BMC Neurosci 9(Highly Accessed)

      Pages: 35-35

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental and spatial expression pattern of alpha-taxilin in the rat central nervous system.2008

    • Author(s)
      Sakakibara S, Nakadate K, Tanaka-Nakadate S, Yoshida K, Nogami S, Shirataki H, Ueda S.
    • Journal Title

      J.Comp.Neurol 511

      Pages: 65-80

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic treatment with melatonin attenuates serotonergic degeneration in the striatum and olfactory tubercle of zitter mutant rats.2008

    • Author(s)
      Ueda S, Sakakibara S, Kadowaki T, Naitoh T, Hirata K, Yoshimoto K.
    • Journal Title

      Neurosci.Lett 448

      Pages: 212-216

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attractin/mahogany protein expression in the rodent central nervous system.2008

    • Author(s)
      Nakadate K, Sakakibara S, Ueda S.
    • Journal Title

      J.Comp.Neurol 508

      Pages: 94-111

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulated expression of neuropeptide Y in hypothalamic-pituitary system of rats by chronic dexamethasone administration.2008

    • Author(s)
      Konno J, Yoshida S, Ina A, Ohmomo H, Shutoh F, Nogami H, Hisano S
    • Journal Title

      Neuroscience Research 60

      Pages: 259-265

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Post-Shaken behavioral malfunction (PSBM) syndrome during development : A proposal of novel model for shaken baby syndrome.2011

    • Author(s)
      Ueda S
    • Organizer
      第116回日本解剖学会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Minocycline alleviates age-dependent dopaminergic cell death in the substantia nigra of zitter mutant rat.2011

    • Author(s)
      Kadowaki T
    • Organizer
      第116回日本解剖学会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Attractin protein expression in the glial cells and dopaminergic neurons of rat brain.2011

    • Author(s)
      Kawamata Y
    • Organizer
      第116回日本解剖学会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生仔期セロトニン神経破壊がおよぼすadult neurogenesisへの影響.セロトニン仮説の再考2010

    • Author(s)
      大桃秀樹, 上田秀一
    • Organizer
      第9回生体脳のニューロン新生懇談会
    • Place of Presentation
      新宿
    • Year and Date
      2010-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生仔期セロトニン神経破壊がおよぼすadult neurogenesisへの影響-セロトニン仮説の再考-2010

    • Author(s)
      大桃秀樹
    • Organizer
      第9回成体脳のニューロン新生懇話会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生仔期脳槽内セロトニン神経毒投与による海馬歯状回の神経細胞新生への影響2010

    • Author(s)
      大桃秀樹
    • Organizer
      第51回日本組織細胞化学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生仔期脳槽内セロトニン神経毒投与による海馬歯状回の神経細胞新生への影響2010

    • Author(s)
      大桃秀樹, 江原鮎香, 中舘和彦, 井上健一, 上田秀一
    • Organizer
      第51回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      秋葉原
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 拡散テンソル画像による幼齢ラット脳の成長に伴う変化の解析2010

    • Author(s)
      若松永憲
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発達期揺さぶり後機能異常症候群Post-Shaken Behavioral Malfunction syndromeの提唱2010

    • Author(s)
      中舘和彦
    • Organizer
      私立大学学術研究高度化推進事業・学術フロンティア推進事業
    • Place of Presentation
      栃木
    • Year and Date
      2010-05-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] げっ歯類脳神経核におけるattractin分布の解析2010

    • Author(s)
      中舘和彦, 榊原伸一, 大桃秀樹, 江原鮎香, 上田秀一
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] げっ歯類脳神経核における attractin 分布の解析2010

    • Author(s)
      中舘和彦, 他
    • Organizer
      日本解剖学会
    • Place of Presentation
      岩手県民会館(岩手県)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 階層性と多様性の問題への挑戦2009

    • Author(s)
      中舘和彦
    • Organizer
      脳科学最前線2009
    • Place of Presentation
      前橋
    • Year and Date
      2009-11-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経回路を見る-電子顕微鏡を用いたシナプスの機能解析-2009

    • Author(s)
      中舘和彦
    • Organizer
      脳科学最前線2009-階層性と多様性の問題への挑戦-
    • Place of Presentation
      前橋工科大学(群馬県)
    • Year and Date
      2009-11-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 選択的神経毒の新生仔期髄液内投与後における再生セロトニン線維の特性2009

    • Author(s)
      上田秀一, 江原鮎香, 大桃秀樹, 中舘和彦, 榊原伸一, 吉本寛司
    • Organizer
      第50回日本組織細胞化学会総会学術集会
    • Place of Presentation
      大津
    • Year and Date
      2009-09-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Zitterラットの進行性黒質ドーパミン神経変性におけるミクログリアの関与2009

    • Author(s)
      中舘和彦, 大桃秀樹, 江原鮎香, 榊原伸一, 上田秀一
    • Organizer
      第50回日本組織細胞化学会総会学術集会
    • Place of Presentation
      大津
    • Year and Date
      2009-09-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of novel genes expressed in the neural progenitor/CNS stem cells.2009

    • Author(s)
      榊原伸一
    • Organizer
      Center for Neuropharmacology & Neuroscience Symposium of Albany Medical College.
    • Place of Presentation
      Albany
    • Year and Date
      2009-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 進行性神経変性疾患モデル動物(Zitterラット)黒質におけるミクログリアの解析2009

    • Author(s)
      中舘和彦, 門脇太郎, 中村新, 榊原伸一, 大桃秀樹, 江原鮎香, 上田秀一
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット主嗅球における小胞性グルタミン酸輸送体の発達変化2009

    • Author(s)
      大桃秀樹, 江原鮎香, 中舘和彦, 榊原伸一, 久野節二, 上田秀一
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 進行性神経変性疾患モデル動物(Zitterラット)黒質におけるミクロクリアの解析2009

    • Author(s)
      中舘和彦, 大桃秀樹, 他
    • Organizer
      日本解剖学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット主嗅球における小胞性グルタミン酸輸送体の発達変化2009

    • Author(s)
      大桃秀樹, 中舘和彦, 他
    • Organizer
      日本解剖学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット主嗅球における小胞性グルタミン酸輸送体1(VGLUT1)とVGLUT2の発達2008

    • Author(s)
      大桃秀樹, 江原鮎香, 中舘和彦, 久野節二, 上田秀一
    • Organizer
      日本解剖学会関東支部第96回学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2008-11-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 進行性神経変性に関与するMahogunin Ring Finger 1 (Mgrn1)のラット中枢神経系における分布解析2008

    • Author(s)
      中舘和彦, 榊原伸一, 大桃秀樹, 江原鮎香, 上田秀一
    • Organizer
      第49回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Zitter ratにおけるFluoro-Jade C(FJC)を用いた神経変性解析の有用性2008

    • Author(s)
      江原鮎香, 中舘和彦, 上田秀一
    • Organizer
      第49回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Zitterミュータントラット黒質におけるドーパミンニューロンの細胞死2008

    • Author(s)
      上田秀一, 榊原伸一, 中舘和彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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