Elucidation of the functional roles of VEGF-positive stromal cells during angiogenesis
| Project/Area Number |
20590199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MORIKAWA Shunichi Tokyo Women's Medical University, 医学部, 助教 (70339000)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血管新生 / 周皮細胞 / 間質細胞 / 創傷治癒 / VEGF / 多重免疫染色 / 電子顕微鏡 / 心筋シート / 基底膜 / 内皮細胞 / 血管内皮細胞 / VEGFA / 細胞シート移植 / 肉芽組織 / 大食細胞 / MMP |
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| Research Abstract |
It is strongly suggested that amongst VEGF-positive stromal cells, pericytes play major roles in the angiogenesis during wound-healing. They presumably promote proliferation and extension of blood vessels in the early stage of angiogenesis, whereas in the later stage, they in turn stabilize newly formed vessels, via such as NG2 signaling pathway. It is also suggested that fibroblasts positive for VEGF along with multiple pericyte markers serve as pericyte precursors during wound-healing.
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Report
(4 results)
Research Products
(49 results)
