The effect of temperature and morphology on insulin secreting signal and insulin secretion in insulin secreting cells
Project/Area Number |
20590208
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General physiology
|
Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
MOGAMI Hideo Hamamatsu University School of Medicine, 医学部, 准教授 (90311604)
|
Co-Investigator(Kenkyū-buntansha) |
TERAKAWA Susumu 浜松医科大学, 光量子医学センター, 教授 (50014246)
SAKURAI Takashi 浜松医科大学, 光量子医学センター, 助教 (50283362)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 膵β細胞 / 細胞内情報伝達 / インスリン / 生体温度 / 形態 / セカンドメッセンジャー / インスリン分泌 / TRPM2チャネル / 全反射蛍光顕微鏡 / カルシウムイオン / calcium ion / insulin secretion / TRPM2 channel / signal / transduction |
Research Abstract |
The effect of temperature and morphology on insulin secretion has been shown using either TRPM2 or Cx36 knockdown pseudoislets.
|
Report
(4 results)
Research Products
(19 results)
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[Journal Article] In vivo imaging analysis of the interaction between unusually large von-Willebrand factor multimers and platelets on the surface of vascular wall2011
Author(s)
Rybaltowski, Miroslaw, Suzuki, Yuko, Mogami, Hideo, Chlebinska, Iwona, Brzoska, Tomasz, Tanaka, Aki, Banno, Fumiaki, Miyata, Toshiyuki, Urano, Tetsumei
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Journal Title
Pfluger Archives-Eur J Physiol
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy.2009
Author(s)
Eisuke Adachi, Yutaka Kazoe, Yohei Sato, Yuko Suzuki, Tetsumei Urano, Takehiko Ueyama, Naoaki Saito, Viacheslav O.Nikolaev, Martin J. Lohse, Makoto Tominaga, Hideo Moeami
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Journal Title
Pfluger Archives-European Journal of Physiology 459
Pages: 227-234
Related Report
Peer Reviewed
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[Journal Article] Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion.2009
Author(s)
Nakagawa Y, Nagasawa M, Yamada S, Hara A, Moeami H, Nikolaev VO, Lohse, MJ, Shigemura N, Ninomiya, Y, Kojima I
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Journal Title
Related Report
Peer Reviewed
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