• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis

Research Project

Project/Area Number 20590289
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionTokai University

Principal Investigator

NAKAYAMA Yukari  Tokai University, 医学部, 特定研究員 (80398750)

Co-Investigator(Kenkyū-buntansha) ANDO Kiyoshi  東海大学, 医学部, 教授 (70176014)
YAHATA Takashi  東海大学, 医学部, 講師 (10398753)
Co-Investigator(Renkei-kenkyūsha) HOZUMI Katsuto  東海大学, 医学部, 准教授 (30246079)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生医学 / 骨と骨髄 / Notch / niche / 造血恒常性 / 骨代謝 / 骨芽細胞 / 造血代謝 / 造骨細胞 / 破骨細胞
Research Abstract

We analyzed the skeletal phenotypes and bone metabolisms of two of Notch ligands transgenic mice, in which Jagged 1(J1) or Delta-like ligand 1 (Dll1) was over-expressed or conditionally deleted. The results revealed for the first time that the Notch signal regulated and maintained bone homeostasis in a ligand specific manner. In addition, the Notch signal indirectly influenced the hematopoietic homeostasis through the proper supply of the hematopoietic stem cell niche in bone marrow, where hematopoiesis primarily occurs throughout the adult life. These results have an important meaning for the development of novel treatment for diseases caused by an abnormal bone metabolism and/or hematopoietic disorders.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (17 results)

  • [Journal Article] Establishment of a xenograft model of human myelodysplastic syndromes.2011

    • Author(s)
      Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
    • Journal Title

      Haematologica. 96(4)

      Pages: 543-51

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo : advantages over bone marrow-derived mesenchymal stem cells.2010

    • Author(s)
      Nakao N, Nakayama T, Yahata T, Muguruma Y, Saito S, Miyata Y, Yamamoto K, Naoe T.
    • Journal Title

      Am J Pathol. 177(2)

      Pages: 547-54

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo : advantages over bone marrow-derived mesenchymal stem cells.2010

    • Author(s)
      Nakano N., et al.
    • Journal Title

      American Journal of Pathology

      Volume: 177 Pages: 547-554

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis.2008

    • Author(s)
      Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K.
    • Journal Title

      Stem Cells. 26(12)

      Pages: 3228-36

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Humanizing bone marrow in immune-deficient mice.2008

    • Author(s)
      Ando K, Muguruma Y, Yahata T
    • Journal Title

      Curr Top Microbiol Immunol. 324(Review)

      Pages: 77-86

    • Related Report
      2010 Final Research Report
  • [Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis.2008

    • Author(s)
      Yahata, et al.
    • Journal Title

      stem Cells. 26(12)

      Pages: 3238-3236

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] : Humanizing bone marrow in immune-deficient mice.2008

    • Author(s)
      Ando, et al.
    • Journal Title

      Curr Top Microbiol Immunol. 324

      Pages: 77-86

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Establishment of xenograft model of human myelodysplastic syndromes.

    • Author(s)
      Muguruma Y., et al.
    • Journal Title

      Haematologica

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010

    • Author(s)
      六車ゆかり、八幡崇、弓野静、盛音、穂積勝人、安藤潔
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010

    • Author(s)
      六車ゆかり
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010

    • Author(s)
      六車ゆかり、八幡崇、穂積勝人、安藤潔
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-07-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010

    • Author(s)
      六車ゆかり
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 造血幹細胞制御におけるNotchシグナルの役割2010

    • Author(s)
      六車ゆかり
    • Organizer
      第10回血液フォーラム21
    • Place of Presentation
      東京
    • Year and Date
      2010-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Importance of Notch signals in maintaining hematopoietic homeostasis.2009

    • Author(s)
      六車ゆかり
    • Organizer
      内藤カンファレンスosteobiology
    • Place of Presentation
      夢舞台(淡路)
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis2009

    • Author(s)
      六車ゆかり
    • Organizer
      日本血液学会
    • Place of Presentation
      国際会議場(京都)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009

    • Author(s)
      八幡崇, 六車ゆかり
    • Organizer
      日本血液学会
    • Place of Presentation
      国際会議場(京都)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis2009

    • Author(s)
      六車ゆかり
    • Organizer
      Stem Cell Conference
    • Place of Presentation
      泉ガーデン(東京)
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis.2009

    • Author(s)
      Muguruma Y, Yahata T, Yumino S, et al.
    • Organizer
      The 26th Naito Conference on Osteobiology
    • Place of Presentation
      Awaji, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Importance of Notch signaling in maintaining hematopoietic homeostasis.2009

    • Author(s)
      Muguruma Y, Yahata Y, Sheng Y, et al.
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009

    • Author(s)
      八幡崇、高梨朋美、盛音、宇野トモ子、六車ゆかり, 他
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis.2009

    • Author(s)
      Muguruma Y, Yahata T, Sheng Y, et al.
    • Organizer
      The 7th Stem Cell Research Symposium
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨髄異形成症候群in vivoモデルの確立2008

    • Author(s)
      六車 ゆかり, 他
    • Organizer
      日本血液学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄造血微小環境の恒常性維持におけるJagged-1分子の重要性2008

    • Author(s)
      八幡 崇, 他
    • Organizer
      日本血液学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄異形成症候群in vivoモデルの確立2008

    • Author(s)
      六車ゆかり, 他
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨髄造血微小環境の恒常性維持におけるJagged-1分子の重要性2008

    • Author(s)
      八幡崇、六車ゆかり, 他
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi