Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis
| Project/Area Number |
20590289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokai University |
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Principal Investigator |
NAKAYAMA Yukari Tokai University, 医学部, 特定研究員 (80398750)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Kiyoshi 東海大学, 医学部, 教授 (70176014)
YAHATA Takashi 東海大学, 医学部, 講師 (10398753)
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| Co-Investigator(Renkei-kenkyūsha) |
HOZUMI Katsuto 東海大学, 医学部, 准教授 (30246079)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医学 / 骨と骨髄 / Notch / niche / 造血恒常性 / 骨代謝 / 骨芽細胞 / 造血代謝 / 造骨細胞 / 破骨細胞 |
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| Research Abstract |
We analyzed the skeletal phenotypes and bone metabolisms of two of Notch ligands transgenic mice, in which Jagged 1(J1) or Delta-like ligand 1 (Dll1) was over-expressed or conditionally deleted. The results revealed for the first time that the Notch signal regulated and maintained bone homeostasis in a ligand specific manner. In addition, the Notch signal indirectly influenced the hematopoietic homeostasis through the proper supply of the hematopoietic stem cell niche in bone marrow, where hematopoiesis primarily occurs throughout the adult life. These results have an important meaning for the development of novel treatment for diseases caused by an abnormal bone metabolism and/or hematopoietic disorders.
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Report
(4 results)
Research Products
(25 results)
