| Project/Area Number |
20590314
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Dokkyo Medical University |
|---|
Principal Investigator |
ITOH Masahiko 獨協医科大学, 医学部, 准教授 (70270486)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 癌 / 転移 / 浸潤 / 細胞増殖 / 小胞輸送 / 細胞運動 / 分泌細胞 |
|---|
| Research Abstract |
A putative vesicular transport protein, taxilin, is expressed in secreting cells such as neuroendocrine cells in the normal colon and rectum. On the other hand, its expression appeared to be elevated in the colon cancer, prostate cancer, and breast cancer as well as in glioblastoma, osteosarcoma, and melanoma cells. The suppression of taxilin in the metastatic breast cancer cell line induced the reduction of cell growth and invasiveness and upregulted the susceptibility to anti-cancer drug, suggesting its functional implication in the specific type of cancer.
|
