Analyses of a vesicular transport protein taxilin in tumorigenesis

• Project/Area Number: 20590314
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Dokkyo Medical University
• Principal Investigator: ITOH Masahiko 獨協医科大学, 医学部, 准教授 (70270486)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 癌 / 転移 / 浸潤 / 細胞増殖 / 小胞輸送 / 細胞運動 / 分泌細胞

Research Abstract

A putative vesicular transport protein, taxilin, is expressed in secreting cells such as neuroendocrine cells in the normal colon and rectum. On the other hand, its expression appeared to be elevated in the colon cancer, prostate cancer, and breast cancer as well as in glioblastoma, osteosarcoma, and melanoma cells. The suppression of taxilin in the metastatic breast cancer cell line induced the reduction of cell growth and invasiveness and upregulted the susceptibility to anti-cancer drug, suggesting its functional implication in the specific type of cancer.

Research Products

• [Journal Article] Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-Myosin II signaling (2012)
  • Author(s): Itoh M, Tsukita S, Yamazaki Y, Sugimoto S
  • Journal Title: Proc Natl Acad Sci USA Volume: (in press)
  • Peer Reviewed
• [Journal Article] Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins (2009)
  • Author(s): Adachi M, Hamazaki Y, Kobayashi Y, Itoh M, Tsukita S, Furuse M, Tsukita S.
  • Journal Title: Mol Cell Biol. Volume: 29(9) Issue: 9 Pages: 2372-89
  • DOI: 10.1128/mcb.01505-08
  • Peer Reviewed
• [Journal Article] Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins (2009)
  • Author(s): Adachi M., et al.
  • Journal Title: Molecular and Cellular Biology 29 Pages: 2372-2389
  • Peer Reviewed
• [Journal Article] Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells (2008)
  • Author(s): Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, Takeuchi K, Fujimori T, Nabeshima Y, Noda T, Tsukita S, Tsukita S
  • Journal Title: Mol Biol Cell Volume: vol.19(6) Issue: 6 Pages: 2465-2475
  • DOI: 10.1091/mbc.e07-12-1215
  • Peer Reviewed
• [Journal Article] Deficiency of ZO-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells (2008)
  • Author(s): Katsuno T., et al.
  • Journal Title: Molecular Biology of the Cell 19 Pages: 2465-2475
  • Peer Reviewed
• [Presentation] The G protein-coupled RhoGEF targets ZO-1 to regulate cortical actomyosin organization in polarized cells (2010)
  • Author(s): 伊藤雅彦, 他
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-12-08