| Project/Area Number |
20590346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KOJIMA Takashi Sapporo Medical University, 医学部, 准教授 (30260764)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Satoshi 札幌医科大学, 医学部, 講師 (30374250)
MURATA Masaki 札幌医科大学, 医学部, 助教 (10404592)
MASAKI Tomoyuki 札幌医科大学, 医学部, 研究員 (30457717)
小笠原 徳子 札幌医科大学, 医学部, 研究員 (00438061)
山口 洋志 札幌医科大学, 医学部, 研究員 (80457704)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自然免疫 / タイト結合 / TLR / RSウィルス / ヒト鼻粘膜 / シグナル伝達 / RSウイルス / アレルギー・ぜんそく / 細胞・組織 / 病理学 / 免疫学 |
|---|
| Research Abstract |
In the present study, we investigated the regulation of human nasal mucosal barrier by tight junctions in the nasal epithelial cells and dendritic cells to prevent and therapy for infections and allergy. TSLP (high-expression in allergic rhinitis), TLR3 (association with innate immunity), PPAR-gamma (nuclear hormone receptor) and RSV (infection in human airway) affected the barrier by tight junctions via distinct signal transduction pathways including PKC.
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