Characterization of tumors from the viewpoint of tumor stem cells
| Project/Area Number |
20590364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Osaka University |
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Principal Investigator |
MORII Eiichi Osaka University, 大学院・医学系研究科, 准教授 (10283772)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腫瘍幹細胞 / 病理診断 / 予後解析 / 腫瘍 / マーカー / 病理学 |
|---|
| Research Abstract |
Tumor is composed of a single clone, but the character of individual tumor cells is different one another. Tumor stem cells are resistant to various anti-tumor therapies, and are responsible for recurrence. The evaluation of the amount of tumor stem cells at diagnosis would be helpful for suitable plan of anti-cancer therapy. However, to date, no such evaluation system was established. Here, we evaluated the amount of tumor stem cells by immunohistochemistry, and revealed that cases with rich tumor stem cells showed poor prognosis.
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Report
(4 results)
Research Products
(70 results)
