| Project/Area Number |
20590371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
KOTANI Koji Iwate Medical University, 医学部, 助教 (50433488)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MASUDA Tomoyuki 岩手医科大学, 医学部, 教授 (10199698)
MAESAWA Chihaya 岩手医科大学, 医学部, 教授 (10326647)
OIKAWA Hiroki 岩手医科大学, 医, 講師 (50285582)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 肝 / 星細胞 / 間質 / ADAM / 相互作用 / 肝臓 / 肝線維症 / 肝星細胞 / エピジェネティックス / 肝炎 / 肝硬変 |
|---|
| Research Abstract |
We have attempted to develop the model of relationship between hepatocellular carcinoma and hepatic stellate cells. For the purpose, we constructed two inducible clones (Tet-kADAM-HepG2 and Tet-kADAM-LI-90). However, both we failed to the cloning of both transfectans. We generated other clones using another system, co-culture markedly decrease tumor cell growth and invasion activity. Thus, the relationships between HSC and hepatocellular carcinoma might contribute to hepatocellular carcinoma development.
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