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Pathogenesis of vasculitis and novel diagnostic and therapeutic strategies

Research Project

Project/Area Number 20590390
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

ISHIZU Akihiro  Hokkaido University, 大学院・保健科学研究院, 教授 (60321957)

Co-Investigator(Kenkyū-buntansha) TOMARU Utano  北海道大学, 大学院・医学研究科, 講師 (20360901)
IWASAKI Sari  北海道大学, 大学院・保健科学研究院, 助教 (60455631)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血管炎 / 自己反応性T細胞 / 網羅的遺伝子発現解析 / 血管内皮細胞 / 末梢血 / 予後予測 / 動物モデル / 胸腺 / トランスクリプトーム解析 / 自己免疫 / トランスクリプトーム
Research Abstract

Autoreactive vasculitogenic T cell clones were established from env-pX rats, which develop medium to small-sized vasculitis. Identification of the T cell target and the mechanism of vascular injury induced by the T cells might result in the development of novel therapeutic strategies for vasculitis. The transcriptome analysis was performed using the peripheral blood obtained from patients with microscopic polyangiitis (MPA) before and 1 week after the treatment. Sixteen genes were nominated as distinguished indicators that could predict prognosis of patients with MPA at an early point during the therapy.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (68 results)

All 2011 2010 2009 2008 Other

All Journal Article (26 results) (of which Peer Reviewed: 23 results) Presentation (39 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes.2011

    • Author(s)
      Iwasaki S, Masuda S, Baba T, Tomaru U, Katsumata K, Kasahara M, Ishizu A
    • Journal Title

      Cytometry A 79A(1)

      Pages: 46-56

    • NAID

      10030575930

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complexity of tumor vasculature and molecular targeting therapies.(Elite Ed)2011

    • Author(s)
      Furuya M, Nagahama K, Ishizu A, Otsuka N, Nagashima Y, Aoki I
    • Journal Title

      Front Biosci 3

      Pages: 549-61

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The incidence and the mechanism of snitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma.2011

    • Author(s)
      Shinohara N, Takahashi M, Kamishima T, Ikushima H, Otsuka N, Ishizu A, Sazawa A, Kanayama H, Nonomura K.
    • Journal Title

      Br J Cancer 104(2)

      Pages: 241-247

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for management of vasculitis syndrome (JCS 2008).2011

    • Author(s)
      JCS Joint Working Group (Ozaki S, Ando M, Isobe M, Kobayashi S, Matsunaga N, Miyata T, Nakabayashi K, Nakajima Y, Nose M, Ohta T, Shigematsu H, Sueishi K, Tanemoto K, Yoshida A, Yoshida M, Yutani C, Arimura Y, Fukaya S, Hamaguchi S, Hashimoto H, Hiromura K, Ishizu A, Iwai T, Kaneko K, Kataoka H, Kawana S, Kida I, Kobayashi Y, Komori K, Masaki H, Matsumoto T, Nagaoka T, Nagasawa K, Nojima Y, Okada M, Okazaki T, Sakamoto I, Shigematsu K, Shiiya N, Takahashi A, Takizawa H, Yamada H, Yoshida S, Fukui T, Horie M, Koike T, Kumagai S, Sasajima T.
    • Journal Title

      Circ J. 75(2)

      Pages: 474-503

    • NAID

      10024034145

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma-dependent, antibody-and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes.2011

    • Author(s)
      Iwasaki S.
    • Journal Title

      Cytometry A

      Volume: 79A Pages: 46-56

    • NAID

      10030575930

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complexity of tumor vasculature and molecular targeting therapies.2011

    • Author(s)
      Furuya M.
    • Journal Title

      Front Biosci (Elite Ed)

      Volume: 3 Pages: 549-561

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The incidence and the mechanism of snitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma.2011

    • Author(s)
      Shinohara N.
    • Journal Title

      Br J Cancer

      Volume: 104 Pages: 241-247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for management of vasculitis syndrome (JCS 2008).2011

    • Author(s)
      JCS Joint Working Group.
    • Journal Title

      Circ J

      Volume: 75 Pages: 474-503

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of multiple human papillomavirus infection in Japanese patients with invasive uterine cervical cancer.2011

    • Author(s)
      Watari H.
    • Journal Title

      Pathobiology

      Volume: (In press,In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic AMP response element binding protein is implicated in IL-6 production from arthritic synovial cells.2010

    • Author(s)
      Ishizu A, Abe A, Miyatake Y, Baba T, Iinuma C, Tomaru U, Yoshiki T.
    • Journal Title

      Mod Rheumatol 20(2)

      Pages: 134-138

    • NAID

      10027168818

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer patients.2010

    • Author(s)
      Takahashi S, Kamiyama T, Tomaru U, Ishizu A, Shida T, Osaka M, Sato Y, Saji Y, Ozaki M, Todo S.
    • Journal Title

      Oncol Rep 24(5)

      Pages: 1201-1212

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] トランスクリプトミクスによる血管炎関連因子の探索2010

    • Author(s)
      石津明洋, 外丸詩野, 村井太一, 山本智宏, 吉木敬
    • Journal Title

      炎症と免疫 18

      Pages: 509-513

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cyclic AMP response element binding protein is implicated in IL-6 production from arthritic synovial cells.2010

    • Author(s)
      Ishizu A.
    • Journal Title

      Mod Rheumatol

      Volume: 20 Pages: 134-138

    • NAID

      10027168818

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer patients.2010

    • Author(s)
      Takahashi S
    • Journal Title

      Oncol Rep

      Volume: 24 Pages: 1201-1212

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic AMP response element binding protein is implicated in IL-6 production from arthritic synovial cells.2010

    • Author(s)
      Ishizu A.
    • Journal Title

      Mod Rheumatol (in press)

    • NAID

      10027168818

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex.2009

    • Author(s)
      Tomaru U, Ishizu A, Murata S, Miyatake Y, Suzuki S, Takahashi S, Kazamaki T, Ohara J, Baba T, Iwasaki S, Fugo K, Otsuka N, Tanaka K, Kasahara M.
    • Journal Title

      Blood 113(21)

      Pages: 5186-5191

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human endogenous retrovirus-R env glycoprotein as possible autoantigen in autoimmune disease.2009

    • Author(s)
      Sasaki N, Ogawa Y, Iinuma C, Tomaru U, Katsumata K, Otsuka N, Kasahara M, Yoshiki T, Ishizu A
    • Journal Title

      AIDS Res Hum Retroviruses 25(9)

      Pages: 889-896

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] env-pXラットの血管炎発症機序2009

    • Author(s)
      石津明洋, 吉木敬
    • Journal Title

      脈管学 49

      Pages: 17-20

    • NAID

      10025626700

    • Related Report
      2010 Final Research Report
  • [Journal Article] MPO-ANCA関連血管炎の予後予測因子の探索2009

    • Author(s)
      石津明洋, 外丸詩野, 村井太一, 吉木敬, 尾崎承一
    • Journal Title

      脈管学 49

      Pages: 45-51

    • NAID

      10025626778

    • Related Report
      2010 Final Research Report
  • [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex.2009

    • Author(s)
      Tomaru U.
    • Journal Title

      Blood 113

      Pages: 5186-5191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human endogenous retrovirus-R env glycoprotein as possible autoantigen in autoimmune disease.2009

    • Author(s)
      Sasaki N.
    • Journal Title

      AIDS Res Hum Retroviruses 25

      Pages: 889-896

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex2009

    • Author(s)
      Tomaru U.
    • Journal Title

      Blood (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rat CD4^+/CD8^+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism.2008

    • Author(s)
      Baba T, Iwasaki S, Maruoka T, Suzuki A, Tomaru U, Ikeda H, Yoshiki T, Kasahara M, Ishizu A
    • Journal Title

      J Immunol 180(5)

      Pages: 2999-3006

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rat CD4^+/CD8^+ macrophages kill tumor cells through an NKG2D-ancgranzyme/perforin-dependent mechanism2008

    • Author(s)
      Baba T.
    • Journal Title

      J Immunol 180

      Pages: 2999-3006

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管炎症候群のガイドライン2008

    • Author(s)
      尾崎承一
    • Journal Title

      Circulation Journal 72(Suppl.IV)

      Pages: 1253-1346

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of multiple human papillomavirus infection in Japanese patients with invasive uterine cervical cancer.

    • Author(s)
      Watari H, Michimata R, Yasuda M, Ishizu A, Xiong Y, Hassan MK, Sakuragi N.
    • Journal Title

      Pathobiology in press

    • NAID

      120003225985

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] First prospective trial, JMAAV, in Japanese patients with MPO-ANCA-associated vasculitis.2010

    • Author(s)
      Ozaki S.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] First prospective trial, JMAAV, in Japanese patients with MPO-ANCA-associated vasculitis.2010

    • Author(s)
      Ozaki S, Makino H, Tomino Y, Yumura W, Yamagata K, Yamada H, Kumagai S, Ishizu A, Kurokawa M, Suka M, Nagafuchi H
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Serum-dependent, antibody and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes.2010

    • Author(s)
      岩崎沙理, 益田紗季子, 馬場智久, 勝俣一晃, 外丸詩野, 笠原正典, 石津明洋
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Skewed T cell development in mice with ectopic expression of thymoproteasome.2010

    • Author(s)
      外丸詩野, 鈴木小百合, 石津明洋, 高橋里実, 小原次郎, 宮武由甲子, 村田茂穂, 田中啓二, 笠原正典
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管炎惹起性T細胞クローンの樹立と解析2010

    • Author(s)
      石津明洋, 外丸詩野, 吉木敬
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2010 Final Research Report
  • [Presentation] JMAAVトランスクリプトーム解析2010

    • Author(s)
      石津明洋, 外丸詩野, 吉木敬, 湯村和子, 山縣邦弘, 山田秀裕, 熊谷俊一, 黒川真奈絵, 須賀万智, 尾崎承一
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2010 Final Research Report
  • [Presentation] 顕微鏡的多発血管炎患者血清ペプチドの網羅的検索2010

    • Author(s)
      高桑由希子, 黒川真奈絵, 大岡正道, 湯村和子, 山縣邦弘, 山田秀裕, 熊谷俊一, 石津明洋, 須賀万智, 尾崎承一, 加藤智啓, 増子佳世
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2010 Final Research Report
  • [Presentation] MPO-ANCA関連血管炎における疾患活動性とQOLへの影響2010

    • Author(s)
      須賀万智, 永渕裕子, 湯村和子, 山縣邦弘, 山田秀裕, 熊谷俊一, 石津明洋, 黒川真奈絵, 尾崎承一
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管炎惹起性T細胞クローンの樹立と解析2010

    • Author(s)
      飯沼千景, 脇雅, 山口まどか, 佐々木直美, 外丸詩野, 石津明洋
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト末梢血に検出されるCD8陽性単球・顆粒球の解析2010

    • Author(s)
      益田紗季子, 岩崎沙理, 馬場智久, 勝俣一晃, 外丸詩野, 笠原正典, 石津明洋
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] 胸腺プロテアソームの異所性発現によるT細胞分化の異常2010

    • Author(s)
      鈴木小百合, 外丸詩野, 高橋里実, 小原次郎, 風巻拓, 小野綾子, 宮武由甲子, 村田茂穂, 田中啓二, 石津明洋, 笠原正典
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] プロテアソームの機能異常による病理作用2010

    • Author(s)
      高橋里実, 外丸詩野, 鈴木小百合, 小野綾子, 宮武由甲子, 風巻拓, 小原次郎, 村田茂穂, 田中啓二, 石津明洋, 笠原正典
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] TNF-α変換酵素(TACE)トランスジェニックマウスの解析2010

    • Author(s)
      深谷進司, 外丸詩野, 松井由希, 保田晋介, 堀田哲也, 片岡浩, 渥美達也, 小池隆夫, 笠原正典, 石津明洋
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] プロテアソームサブユニット・5tの胸腺腫における発現2010

    • Author(s)
      山田洋介, 外丸詩野, 木内隆之, 丸川活司, 笠原正典, 石津明洋, 松野吉宏
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] von Recklinghausen病による動脈破裂の病理組織学検討2010

    • Author(s)
      木内隆之, 外丸詩野, 高田明生, 石津明洋
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] A演説(学術研究賞)モデル動物の解析による自己免疫疾患発症機序の多面的理解2009

    • Author(s)
      石津明洋.
    • Organizer
      第55回日本病理学会秋期特別総会
    • Place of Presentation
      九段会館(東京都)
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] A演説(学術研究賞)モデル動物の解析による自己免疫疾患発症機序の多面的理解2009

    • Author(s)
      石津明洋
    • Organizer
      第55回日本病理学会秋期特別総会
    • Place of Presentation
      九段会館(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] MPO-ANCA関連血管炎患者末梢血のトランスクリプトーム解析2009

    • Author(s)
      石津明洋, 外丸詩野, 岩崎沙理, 吉木敬, 尾崎承一
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] MPO-ANCA関連血管炎患者末梢血のトランスクリプトーム解析2009

    • Author(s)
      石津明洋, 外丸詩野, 岩崎沙理, 飯沼千景, 村井太一, 山本智宏, 吉木敬, 尾崎承一
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] 自己血管内皮細胞反応性ラットT細胞の解析2009

    • Author(s)
      飯沼千景, 佐々木直美, 岩崎沙理, 外丸詩野, 石津明洋
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] プロテアソームのキモトリプシン様活性の異常と病態形成に関する検討2009

    • Author(s)
      外丸詩野, 石津明洋, 高橋里実, 鈴木小百合, 小原次郎, 風巻拓, 宮武由甲子, 村田茂穂, 田中啓二, 笠原正典
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] 胸腺プロテアソームの発現とT 細胞分化に関する検討2009

    • Author(s)
      鈴木小百合, 外丸詩野, 石津明洋, 高橋里実, 小原次郎, 風巻拓, 宮武由甲子, 村田茂穂, 田中啓二, 笠原正典
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト末梢血に検出されるCD8 陽性単球の解析2009

    • Author(s)
      岩崎沙理, 馬場智久, 益田紗季子, 勝俣一晃, 外丸詩野, 笠原正典, 石津明洋
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] Establishment and analysis of vasculitogenic T cell clone.2009

    • Author(s)
      Iinuma C, Waki M, Yamaguchi M, Sasaki N, Tomaru U, Ishizu A
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Final Research Report
  • [Presentation] Skewed T cell development in mice with ectopic expression of thymoproteasome.2009

    • Author(s)
      鈴木小百合, 外丸詩野, 石津明洋, 高橋里実, 小原次郎, 風巻拓, 宮武由甲子, 村田茂穂, 田中啓二, 笠原正典
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of CD8 positive monocytes and granulocytes in human peripheral blood.2009

    • Author(s)
      益田紗季子, 岩崎沙理, 馬場智久, 勝俣一晃, 外丸詩野, 笠原正典, 石津明洋
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Final Research Report
  • [Presentation] Gene expression profiling of peripheral blood before and after treatment of patients with MPO-ANCA-associated vasculitis : transcriptomics in JMAAV study2008

    • Author(s)
      Ishizu A.
    • Organizer
      APLAR
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene expression profiling of peripheral blood before and after treatment of patients with MPO-ANCA-associated vasculitis : transcriptomics in JMAAV study.2008

    • Author(s)
      石津明洋, 外丸詩野, 村井太一, 西平順, 吉木敬, 尾崎承一
    • Organizer
      APLAR
    • Place of Presentation
      Yokohama, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] 自己血管内皮細胞反応性ラットT細胞の解析2008

    • Author(s)
      石津明洋, 外丸詩野, 飯沼千景, 岩崎沙理, 佐々木直美, 馬場智久, 笠原正典, 吉木敬
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2010 Final Research Report
  • [Presentation] MPO-ANCA 関連血管炎患者末梢血のトランスクリプトーム解析2008

    • Author(s)
      石津明洋, 外丸詩野, 村井太一, 西平順, 吉木敬, 尾崎承一
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      ホテル日航金沢(金沢)
    • Related Report
      2010 Final Research Report
  • [Presentation] 自己血管内皮細胞反応性ラットT細胞の解析2008

    • Author(s)
      石津明洋, 外丸詩野, 岩崎沙理, 飯沼千景, 佐藤亜矢, 佐々木直美, 馬場智久, 笠原正典, 吉木敬
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      ホテル日航金沢(金沢)
    • Related Report
      2010 Final Research Report
  • [Presentation] 胸腺プロテアソームの発現とT細胞分化に関する検討2008

    • Author(s)
      外丸詩野, 石津明洋, 宮武由甲子, 高橋里美, 小原次郎, 村田茂穂, 田中啓二, 笠原正典
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      ホテル日航金沢(金沢)
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト組織におけるプロテアソームサブユニット・5t発現に関する検討2008

    • Author(s)
      外丸詩野, 石津明洋, 宮武由甲子, 鈴木小百合, 風巻拓, 村田茂穂, 田中啓二, 笠原正典
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      ホテル日航金沢(金沢)
    • Related Report
      2010 Final Research Report
  • [Presentation] CD4/CD8 double positiveマクロファージの発見と自然免疫系における新しいエフェクター細胞としての展開2008

    • Author(s)
      馬場智久, 岩崎沙理, 外丸詩野, 池田仁, 吉木敬, 笠原正典, 向田直史, 石津明洋
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      ホテル日航金沢(金沢)
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト末梢血におけるCD8陽性単球の解析2008

    • Author(s)
      岩崎沙理, 馬場智久, 勝俣一晃, 外丸詩野, 笠原正典, 石津明洋
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      ホテル日航金沢(金沢)
    • Related Report
      2010 Final Research Report
  • [Presentation] 顕微鏡的多発血管炎患者末梢血のトランスクリプトーム解析2008

    • Author(s)
      石津明洋, 外丸詩野, 村井太一, 吉木敬, 尾崎承一
    • Organizer
      第54回日本病理学会秋期特別総会
    • Place of Presentation
      松山市総合コミュニティーセンター(松山)
    • Related Report
      2010 Final Research Report
  • [Presentation] The mechanism of vascular injury induced by T-cells autoreactive with endothelial cells.2008

    • Author(s)
      石津明洋, 外丸詩野, 岩崎沙理, 飯沼千景, 馬場智久, 佐々木直美, 笠原正典, 吉木敬
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] Preferential expression of proteasome subunit ・5t in the human thymus.2008

    • Author(s)
      外丸詩野, 石津明洋, 宮武由甲子, 村田茂穂, 鈴木小百合, 高橋里実, 風巻拓, 小原次郎, 田中啓二, 笠原正典
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] CD8+ monocytes in human peripheral blood.2008

    • Author(s)
      岩崎沙理, 馬場智久, 益田紗季子, 勝俣一晃, 外丸詩野, 笠原正典, 石津明洋
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.hs.hokudai.ac.jp/graduate/study/member/index.html

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 自己免疫疾患の被験者に対する治療効果の予測方法2008

    • Inventor(s)
      石津明洋, 外丸詩野, 村井太一, 吉木敬, 尾崎承一
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2008
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 自己免疫疾患の被験者に対する治療効果の予測定法2008

    • Inventor(s)
      石津明洋ほか
    • Industrial Property Rights Holder
      北海道大学ほか
    • Filing Date
      2008-09-24
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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