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Development of a novel therapeutic for AIDS rapidly disseminating in Okinawa and evaluation of it using humanized mouse model

Research Project

Project/Area Number 20590403
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

OKUMA Kazu  National Institute of Infectious Diseases, 血液・安全性研究部, 室長 (80315085)

Co-Investigator(Kenkyū-buntansha) TANAKA Yuetsu  琉球大学, 免疫学講座, 教授 (30163588)
FUJITA Jiro  琉球大学, 感染病態制御学講座, 教授 (80209056)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsヒト免疫不全ウイルス1型 / エイズ / 新規治療薬 / 感染実験動物モデル / ヒト化マウス
Research Abstract

As candidates for novel drugs to control AIDS/human immunodeficiency virus type 1 (HIV-1) infection, a recombinant vesicular stomatitis virus (VSV) expressing HIV-1 receptors and CXCR4 antagonist were evaluated. In vitro and in immunodeficient mice transplanted with human peripheral blood mononuclear cells or with human hematopoietic stem cells (humanized mice), both candidates could inhibit HIV-1 infection definitely, indicating that they have a potentially therapeutic value for AIDS/HIV-1 infection.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] A recombinant vesicular stomatitis virus encoding HIV-1 receptors and human OX40 ligand efficiently eliminates HIV-1-infected CD4-positive T cells expressing OX402011

    • Author(s)
      Okuma K, Tsuruno C, Takahashi Y, Tanaka R, Tanaka Y, Takahama Y, Hamaguchi Y, Hamaguchi I, Yamaguchi K
    • Journal Title

      Human Immunology 72(4)

      Pages: 295-304

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A-recombinant vesicular stomatitis virus encoding HIV-1 receptors and human OX40 ligand efficiently eliminates HIV-1-infected CM-positive Tcells expressing OX402011

    • Author(s)
      K.Okuma, C.Tsuruno.
    • Journal Title

      Human Immunology

      Volume: 72(4) Pages: 295-304

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The novel CXCR4 antagonist, KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection : comparative studies with AMD31002009

    • Author(s)
      Murakami T, Kumakura S, Yamazaki T, Tanaka R, Hamatake M, Okuma K, Huang W, Toma J, Komano J, Yanaka M, Tanaka Y, Yamamoto N
    • Journal Title

      Antimicrobial Agents and Chemotherapy 53(7)

      Pages: 2940-2948

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The novel CXCR4 antagonist, KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virustype 1 infection : comparative studies with AMD31002009

    • Author(s)
      Tsutomu Murakami
    • Journal Title

      Antimicrobial Agents and Chemotherapy 53(7)

      Pages: 2940-2948

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト化NOGマウスを用いたX4 HIV-1標的組換えVSVの治療効果の検討2010

    • Author(s)
      大隈和
    • Organizer
      第24回日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2010 Final Research Report
  • [Presentation] A recombinant vesicular stomatitis virus encoding HIV-1 receptors and OX40 ligand as a novel potential anti-HIV-1 therapeutic agent2010

    • Author(s)
      大隈和
    • Organizer
      XVIII International AIDS Conference
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2010-07-19
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] R5 HIV-1感染を制御する組換えVSVの開発とOX40L発現による効果増強2010

    • Author(s)
      大隈和
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島(あわぎんホール)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 活性化T細胞免疫刺激分子OX40を介したHIV-1感染抑制効果の検討2010

    • Author(s)
      深川耕次
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島(あわぎんホール)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト化NOGマウスを用いたX4 HIV-1標的組換えVSVの治療効果の検討2010

    • Author(s)
      大隈和
    • Organizer
      第24回日本エイズ学会学術集会
    • Place of Presentation
      東京(グランドプリンス高輪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規バイオ治療薬候補のヒト化マウス感染モデルを用いた評価:CCR5指向性HIV-1感染細胞を選択的に破壊する組換えウイルスVSV2009

    • Author(s)
      大隈和
    • Organizer
      第23回日本エイズ学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] CD4、CXCR4を併せ持つ新規HIV攻撃用VSVの作製:OX40リガンド共発現の効果2009

    • Author(s)
      大隈和
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規レポーターアッセイ系を用いたHIV-1スプライシングに関与する宿主因子の検討2009

    • Author(s)
      鶴野親是
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] R5 HIV-1感染細胞を標的とし感染を制御する組換えウイルスVSV2008

    • Author(s)
      大隈和
    • Organizer
      第22回日本エイズ学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] R5 HIV-1感染細胞を標的とし感染を制御する組換えウイルスVSV2008

    • Author(s)
      大隈和
    • Organizer
      第22回日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] KRH-3955は経口投与可能な高活性抗X4HIV-1阻害剤である2008

    • Author(s)
      村上努
    • Organizer
      第22回日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-11-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel potential anti-HIV-1 therapeutic based on a vesicular stomatitis virus expressing HIV-1 receptors and OX40 ligand2008

    • Author(s)
      Kazu Okuma
    • Organizer
      XVII International AIDS Conference
    • Place of Presentation
      Mexico City, Mexico
    • Year and Date
      2008-08-05
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.nih.go.jp/niid/safety/safety3.html

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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