| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
The aim of this study is to explore molecular targets for therapy of cancer metastasis. At first, we established a new model for breast cancer metastasis to liver. Next, we identified S100A14 and EMU1 as novel metastasis-related molecules. Experimentally, S100A14 promoted cancer cell invasion and metastasis and clinically, up-regulated expression of this protein correlated with poor survival of breast cancer patients. EMU1 protein inhibited cell-matrix adhesion and promoted detachment of cancer cells. These molecules can be new targets for drug development in cancer diagnosis and therapies.
|
