Establishment of animal model for various types of cancer metastasis and analysis of the molecular mechanism
| Project/Area Number |
20590406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SUGINO Takashi Fukushima Medical University, 医学部, 准教授 (90171165)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / 転移 / 実験モデル / 腫瘍血管 / 分子メカニズム / 浸潤 / S100A14 / 乳癌 / RNAi / Semaphorin 3B / マウス乳癌 / がん転移 / 遺伝子導入 / マウス乳がんモデル / anoikis |
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| Research Abstract |
The aim of this study is to explore molecular targets for therapy of cancer metastasis. At first, we established a new model for breast cancer metastasis to liver. Next, we identified S100A14 and EMU1 as novel metastasis-related molecules. Experimentally, S100A14 promoted cancer cell invasion and metastasis and clinically, up-regulated expression of this protein correlated with poor survival of breast cancer patients. EMU1 protein inhibited cell-matrix adhesion and promoted detachment of cancer cells. These molecules can be new targets for drug development in cancer diagnosis and therapies.
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Report
(4 results)
Research Products
(37 results)
