The role of TGF-βsignaling in malignant mesothelioma cell growth

• Project/Area Number: 20590420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: MAKIKO Fujii Aichi Cancer Center Research Institute, 分子腫瘍学部, 主任研究員 (70406031)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 悪性胸膜中皮腫 / TGF-β / 悪性中皮腫 / YAP / CTGF

Research Abstract

Loss of NF2 is one of the genetic lesions which have been related to the growth of human malignant mesothelioma (MM). We found that the expression of CTGF induced by TGF-βin MM cell lines was greatly affected by defect in Hippo signaling cascade. Our results suggested that both TGF-βand CTGF might be candidate for molecular target therapy of MM.

Research Products

• [Journal Article] LATS2 is a tumor suppressor gene of malignant mesothelioma. (2011)
  • Author(s): Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y.
  • Journal Title: Cancer Res 71 Pages: 873-83
• [Journal Article] Regulation of endothelial barrier function by TGF-β type I receptor ALK5 : Potential role of contractile mechanisms and heat shock protein 90. (2011)
  • Author(s): Antonov AS, Antonova GN, Fujii M, Dijke PT, Handa V, Catravas JD, Verin AD.
  • Journal Title: J Cell Physiol
• [Journal Article] Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells. (2009)
  • Author(s): Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y.
  • Journal Title: Carcinogenesis 30(7) Pages: 1097-105
• [Journal Article] Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. (2009)
  • Author(s): Goto Y, Shinjo K, Kondo Y, Shen L,Toyota M, Suzuki H, Gao W, An B, Fujii M, Murakami H, Osada H, Taniguchi T, Usami N, Kondo M, Hasegawa Y, Shimokata K, Matsuo K, Hida T, Fujimoto N, Kishimoto T, Issa JP, Sekido Y.
  • Journal Title: Cancer Res 69(23) Pages: 9073-82
• [Presentation] The role of TGF-β signaling in human malignant mesothelioma cells (2010)
  • Author(s): 藤井万紀子
  • Organizer: 第69回日本癌学会学術総会第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] TGF-β controls the Malignant Mesothelioma cell growth synergistically with YAP (2010)
  • Author(s): Makiko Fujii
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場、リーガロイヤルホテル大阪(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] 悪性中皮腫細胞の増殖におけるTGF-βシグナルおよびYAPの協調的役割 (2010)
  • Author(s): 藤井万紀子
  • Organizer: 第14回学術集会日本がん分子標的治療学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-08
• [Presentation] 悪性中皮腫細胞の増殖におけるTGF-βシグナルおよびYAPの協調的役割について (2010)
  • Author(s): 藤井万紀子
  • Organizer: 第14回がん分子標的治療学会第14回がん分子標的治療学会
  • Place of Presentation: 東京船堀タワーホール
  • Year and Date: 2010-07-07
• [Presentation] 悪性中皮腫細胞の増殖におけるTGF-βシグナルおよびYAPの協調的役割について (2010)
  • Author(s): 藤井万紀子
  • Organizer: 第83回日本組織培養学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-05-24
• [Presentation] 悪性中皮腫細胞の増殖におけるTGF-βシグナルおよびYAPの協調的役割 (2010)
  • Author(s): 藤井万紀子
  • Organizer: 日本組織培養学会第83回大会
  • Place of Presentation: 岡山大学創立50周年記念会館(岡山県)
  • Year and Date: 2010-05-21
• [Presentation] The role of TGF-β signaling in growth of human malignant mesothelioma cells (2009)
  • Author(s): 藤井万紀子
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] The role of TGF-β signaling in growth of human malignant mesothelioma cells (2009)
  • Author(s): 藤井万紀子
  • Organizer: 第68日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] The role of TGF-β signaling in growth of human malignant mesothelioma cells (2009)
  • Author(s): 藤井万紀子
  • Organizer: FASEB Summer Research Conferences ; The TGF-β Superfamily
  • Place of Presentation: Arizona, USA
  • Year and Date: 2009-06-15
• [Presentation] The role of TGF-β signaling in growth of human malignant mesothelioma cells (2009)
  • Author(s): 藤井万紀子
  • Organizer: FASEB Summer Research Conferences ; The TGF-β Superfamily
  • Place of Presentation: Arizona、USA
  • Year and Date: 2009-06-15
• [Presentation] 悪性中皮腫細胞の増殖におけるTGF-β, Smadシグナル伝達系の役割 (2009)
  • Author(s): 藤井万紀子
  • Organizer: 第82回日本組織培養学会
  • Place of Presentation: 独協医科大学
  • Year and Date: 2009-05-18
• [Presentation] 悪性中皮腫細胞の増殖におけるTGF-β,Smadシグナル伝達系の役割 (2009)
  • Author(s): 藤井万紀子
  • Organizer: 第82回日本組織培養学会総会
  • Place of Presentation: 栃木県独協医大
  • Year and Date: 2009-05-18
• [Presentation] Thae Role of TGF-β Signaling in Human Malignant Mesothelioma (2008)
  • Author(s): 藤井万紀子
  • Organizer: 67th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] The Role of TGF-β signaling in human Malignant Mesothelioma (2008)
  • Author(s): 藤井万紀子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 悪性中皮腫に対するTGF-βシグナルの影響 (2008)
  • Author(s): 藤井万紀子
  • Organizer: 第81回日本組織培養学会大会
  • Place of Presentation: つくば
  • Year and Date: 2008-05-19
• [Presentation] 悪性中皮腫に対するTGF-βシグナルの影響 (2008)
  • Author(s): 藤井万紀子
  • Organizer: 第81日本組織培養学会総会
  • Place of Presentation: つくば
  • Year and Date: 2008-05-19
• [Remarks] ホームページ等