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Functional analysis of CRISP homologues of schistosome

Research Project

Project/Area Number 20590435
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

KANAZAWA Tamotsu  University of Occupational and Environmental Health, Japan, 医学部, 教授 (10194888)

Co-Investigator(Kenkyū-buntansha) OSADA Yoshio  産業医科大学, 医学部, 准教授 (80282515)
Co-Investigator(Renkei-kenkyūsha) TAKEO Satoru  愛媛大学, 無細胞生命科学工学研究センター, 講師 (40302666)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords感染症 / 寄生虫 / 住血吸虫 / 免疫回避 / 分泌タンパク / CRISP / SCP / Tpx-1 / PR-1 / CRISP/SCP/Tpx-1/PR-1 / ワクチン / サイトカイン
Research Abstract

Venom allergen-like proteins (VALs) are schistosome homologues of secreted proteins CRISP/SCP/Tpx-1/PR-1 widely distributed among various species of organisms and their biological roles are unknown. In this study we have successfully cloned some of the VAL molecules from Schistosoma mansoni. VAL-3 augmented production of an immunosuppresiive cytokine IL-10 from mouse spleen cells. This result suggest the possibility that VAL molecules might be involved in the parasite-induced immunomodulation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (19 results)

  • [Journal Article] Parasitic helminths : New weapons against immunological disorders. Special Issue "Immunology and Cell Biology of Parasitic Diseases"2010

    • Author(s)
      Osada Y, Kanazawa T
    • Journal Title

      J Boimed.Biotechnol. 2010

      Pages: 743758-743758

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and differentiation of human schistosomes by polymerase chain reaction.2010

    • Author(s)
      Kato-Hayashi N, Kirinoki M, Iwamura Y, Kanazawa T, Kitikoon V, Matsuda H, Chigusa Y
    • Journal Title

      Exp Parasitol. 124(3)

      Pages: 325-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Schistosoma mansoni has anti-arthritic effects accompanied with IL-17's down-modulation dependent on viable eggs2010

    • Author(s)
      Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
    • Journal Title

      Proceedings of XIIth International Congress of Parasitology

      Volume: XIIth Pages: 113-116

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Identification and differentiation of human schistosomes by polymerase chain reaction2010

    • Author(s)
      Kato-Hayashi N, Kirinoki M, Iwamura Y, Kanazawa T, Kitikoon V, Matsuda H, Chigusa Y.
    • Journal Title

      Experimental Parasitology

      Volume: 124 Pages: 325-329

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parasitic Helminths : New Weapons against Immunological Disorders2010

    • Author(s)
      Osada Y.
    • Journal Title

      J Biomed Biotechnol 2010

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators.2009

    • Author(s)
      Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
    • Journal Title

      Int J Parasitol. 39(4)

      Pages: 457-64

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide.2009

    • Author(s)
      Kumagai T, Osada Y, Ohta N, Kanazawa T
    • Journal Title

      Mol Biochem Parasitol. 164(1)

      Pages: 26-31

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflam matory mediators2009

    • Author(s)
      Osada Y.
    • Journal Title

      International Journal for Parasitology 39

      Pages: 457-464

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Experimental Schistosoma mansoni infection suppresses autoimmune arthritis in mice.2010

    • Author(s)
      長田良雄
    • Organizer
      EPS Global-Shanghai 1st International Biomedicine Forum.
    • Place of Presentation
      上海,中国
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 住血吸虫による関節炎抑制には、炎症性サイトカインの産生抑制が伴う2010

    • Author(s)
      長田良雄、清水少一、熊谷貴、山田壮亮、金澤保
    • Organizer
      第75回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2010-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 住血吸虫による関節炎抑制には、炎症性サイトカインの産生抑制が伴う2010

    • Author(s)
      長田良雄、清水少一、熊谷貴、山田壮亮、金澤保
    • Organizer
      第75回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 住血吸虫によるThサイトカイン修飾に関与する因子の解析2010

    • Author(s)
      長田良雄、金澤保
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川
    • Year and Date
      2010-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Schistosoma mansoni has anti-arthritic effects accompanied with IL-17's down-modulation dependent on viable eggs.2010

    • Author(s)
      長田良雄, 清水少一, 熊谷貴, 山田壮亮, 金澤保
    • Organizer
      XIIth International Congress of Parasitology.
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] 住血吸虫によるThサイトカイン修飾に関与する因子の解析2010

    • Author(s)
      長田良雄、金澤保
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      大雪クリスタルホール(旭川市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Schistosoma mansoni has anti-arthritic effects accompanied with IL-17's down-modulation dependent on viable eggs2010

    • Author(s)
      Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
    • Organizer
      XIIth International Congress of Parasitology
    • Place of Presentation
      Melbourne Convention & Exhibition Centre(メルボルン/オーストラリア)
    • Related Report
      2010 Annual Research Report
  • [Presentation] コラーゲン関節炎に対する蠕虫感染の影響-Heligmosomoides polygyrusの場合-2010

    • Author(s)
      長田良雄、黒田悦史、金澤保
    • Organizer
      第63回日本寄生虫学会南日本支部大会 第60回日本衛生動物学会南日本支部大会合同大会
    • Place of Presentation
      鹿児島大・農学部共通棟(鹿児島市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスにおける住血吸虫の抗関節炎・免疫修飾効果の解析2009

    • Author(s)
      長田良雄、金澤保
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 寄生蠕虫研究の新しい方向性-治療薬としての蠕虫の可能性-2009

    • Author(s)
      長田良雄、金澤保
    • Organizer
      第62回日本寄生虫学会南日本支部大会・第59回日本衛生動物学会南日本支部大会・合同大会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 住血吸虫卵の炎症性Thサイトカイン産生に対する影響2009

    • Author(s)
      長田良雄、井上嘉乃、米本知世、金澤保
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 寄生蠕虫研究の新しい方向性 -治療薬としての蠕虫の可能性-(シンポジウム:これからの寄生虫学を語る)2009

    • Author(s)
      長田良雄
    • Organizer
      第62回日本寄生虫学会南日本支部大会
    • Place of Presentation
      福岡(福岡大学)
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスにおける住血吸虫の抗関節炎・免疫修飾効果の解析2009

    • Author(s)
      長田良雄
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 寄生虫感染によるマウス関節炎の抑制2008

    • Author(s)
      長田良雄、熊谷貴、清水少一、金澤保
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 寄生虫感染によるマウス関節炎の抑制2008

    • Author(s)
      長田良雄
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 住血吸虫感染による関節炎予防効果-炎症性サイトカインの解析-2008

    • Author(s)
      長田良雄、金澤保
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2008-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 住血吸虫感染による関節炎予防効果-炎症性サイトカインの解析-2008

    • Author(s)
      長田良雄
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-04-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Schistosome infection suppresses collagen-induced arthritis in mice.2008

    • Author(s)
      長田良雄, 清水少一, 熊谷貴, 山田壮亮, 金澤保
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria.
    • Place of Presentation
      Cheju, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Schistosome infection suppresses collagen-induced arthritis in mice2008

    • Author(s)
      Osada Y.
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria
    • Place of Presentation
      韓国・済州島
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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