| Project/Area Number |
20590476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
FUJII Nobuhiro Sapporo Medical University, 医学部, 教授 (90133719)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOTA Shinーichi 札幌医科大学, 医学部, 准教授 (10325863)
OKABAYASHI Tamaki 札幌医科大学, 医学部, 講師 (10359995)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 病原性 / 感染免疫 / ウイルス / TLR / シグナル伝達 / 増殖制御 / 再活性化 / 熱ショック蛋白 / 免疫複合体 / 持続感染 |
|---|
| Research Abstract |
We investigated the fluctuation of virus growth via activation of TLR signaling pathway in persistently or acutely infected cells with measles, mumps or herpes simplex viruses. The fluctuation was not recognaized in lymphoid cell lines persistently infected with these viruses through treatment with LPS or HSP. On the other hand, release of herpes simplex virus type 1 was significantly suppressed by pretreatment of FL cells with imiquimod.
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