| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
Mitogen-activated protein kinases (MAPKs) such as ERK and p38 are involved in the regulation of inflammation and various biological phenomena through signal transductions. To elucidate the in vivo functions of ERK and p38, we have established ERK2 and p38α conditional knockout mice. The study of these mice revealed that ERK2 and p38α are involved in the regulation of lymphocyte development and metabolic syndrome, respectively. These results suggest that signaling molecules in the MAPK pathways are candidate targets to control immune responses and/or chronic inflammation induced by obesity.
|
