Clinical and genetic factors of drug-induced QT interval prolongation in patients who receive cancer chemotherapy
Project/Area Number |
20590537
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied pharmacology
|
Research Institution | Nagoya University |
Principal Investigator |
ANDO Yuichi Nagoya University, 医学部附属病院, 准教授 (10360083)
|
Co-Investigator(Kenkyū-buntansha) |
SAWAKI Masataka 名古屋大学, 大学院・医学研究科, 特任講師 (20402597)
MITSUMA Ayako 名古屋大学, 大学院・医学研究科, 特任助教 (10467326)
SATO Mitsuo 国立長寿医療センター病院, 医長 (70467281)
KAWADA Kenji 名古屋大学, 医学部附属病院, 病院助手 (30418743)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | がん化学療法 / QT延長 / 医薬品副作用 / 遺伝子多型 |
Research Abstract |
This study assessed the characteristics of QT intervals and arrhythmias in women with breast cancer who received chemotherapy with a combination of epirubicin, cyclophosphamide and 5-fluorouracil. QT intervals could be measured in 127 records in 34 patients. There was a significant trend toward QT interval prolongation after each treatment. No patient had serious arrhythmias. There was no association between QT interval prolongation and the SNPs of potassium channel genes.
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Report
(4 results)
Research Products
(18 results)