Clinical and genetic factors of drug-induced QT interval prolongation in patients who receive cancer chemotherapy

• Project/Area Number: 20590537
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Nagoya University
• Principal Investigator: ANDO Yuichi Nagoya University, 医学部附属病院, 准教授 (10360083)
• Co-Investigator(Kenkyū-buntansha): SAWAKI Masataka 名古屋大学, 大学院・医学研究科, 特任講師 (20402597) ; MITSUMA Ayako 名古屋大学, 大学院・医学研究科, 特任助教 (10467326) ; SATO Mitsuo 国立長寿医療センター病院, 医長 (70467281) ; KAWADA Kenji 名古屋大学, 医学部附属病院, 病院助手 (30418743)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: がん化学療法 / QT延長 / 医薬品副作用 / 遺伝子多型

Research Abstract

This study assessed the characteristics of QT intervals and arrhythmias in women with breast cancer who received chemotherapy with a combination of epirubicin, cyclophosphamide and 5-fluorouracil. QT intervals could be measured in 127 records in 34 patients. There was a significant trend toward QT interval prolongation after each treatment. No patient had serious arrhythmias. There was no association between QT interval prolongation and the SNPs of potassium channel genes.

Research Products

• [Journal Article] Prospective evaluation of corrected QT intervals and arrhythmias after exposure to epirubicin, cyclophosphamide, and 5-fluorouracil in women with breast cancer. (2011)
  • Author(s): Koichi Kitagawa, Kenji Kawada, Ayako Mitsuma, Masataka Sawaki, Yuichi Ando, et al.
  • Journal Title: Ann Oncol in press
  • Peer Reviewed
• [Journal Article] Prospective evaluation of corrected QT intervals and arrhythmias after exposure to epirubicin, cyclophosphamide, and 5-fluorouracil in women with breast cancer. (2011)
  • Author(s): Koichi Kitagawa
  • Journal Title: Ann Oncol Volume: in press
  • Peer Reviewed
• [Journal Article] Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genes. (2010)
  • Author(s): Megumi Inada, Mitsuo Sato, Ayako Mitsuma, Masataka Sawaki, Yuichi Ando, et al.
  • Journal Title: Int J Clin Pharmacol Ther 48 Pages: 729-734
  • Peer Reviewed
• [Journal Article] Prospective evaluation of pharmaco- kinetically guided dosing of carboplatin in Japanese patients with cancer. (2010)
  • Author(s): Tomoya Shimokata, Yuichi Ando, et al.
  • Journal Title: Cancer Sci 101 Pages: 2601-2605
  • NAID: 10027834680
  • Peer Reviewed
• [Journal Article] Pharmacokinetic analysis of carboplatin in patients with cancer who are undergoing hemodialysis. (2010)
  • Author(s): Tomoyo Oguri, Yuichi Ando, et al.
  • Journal Title: Cancer Chemother Pharmacol 66 Pages: 813-817
  • Peer Reviewed
• [Journal Article] Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTPI genes. (2010)
  • Author(s): Megumi Inada
  • Journal Title: Int J Clin Pharmacol Ther Pages: 729-734
  • Peer Reviewed
• [Journal Article] Prospective evaluation of pharmacokinetically guided dosing of carboplatin in Japanese patients with cancer. (2010)
  • Author(s): Tomoya Shimokata
  • Journal Title: Cancer Sci Volume: 101 Pages: 2601-2605
  • Peer Reviewed
• [Journal Article] Pharmacokinetic analysis of carboplatin in patients with cancer who are undergoing hemodialysis. (2010)
  • Author(s): Tomoyo Oguri
  • Journal Title: Cancer Chemother Pharmacol Pages: 813-817
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 安藤雄一(執筆および編集)
  • Journal Title: 外来がん化単療法マニュアル(文光堂)
• [Presentation] 塩酸イリノテカンのPK/PDとPGx研究の流れ 抗がん剤のPK/PDとPGx～個別化投薬に向けて～ (2010)
  • Author(s): 安藤雄一
  • Organizer: 第31回日本臨床薬理学会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2010-12-02
• [Presentation] 塩酸イリノテカンのPK/PDとPGx研究の流れ.抗がん剤のPKIPDとPGx～個別化投薬に向けて～ (2010)
  • Author(s): 安藤雄一
  • Organizer: 第31回日本臨床薬理学会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2010-12-02
• [Presentation] The fruits of transla- tional research and their application to clinical practice : genotype- based individualization of irinotecan chemotherapy. (2010)
  • Author(s): 安藤雄一
  • Organizer: 第9回アジア臨床腫瘍学会
  • Place of Presentation: 岐阜グランドホテル
  • Year and Date: 2010-08-25
• [Presentation] The fruits of translational research and their application to clinical practice : genotype-based individualization of irinotecan chemotherapy. (2010)
  • Author(s): Yuichi Ando
  • Organizer: 第9回アジア臨床腫瘍学会
  • Place of Presentation: 岐阜グランドホテル
  • Year and Date: 2010-08-25
• [Presentation] 多剤併用化学療法におけるQTc間隔延長と催不整脈作用の臨床的探索 (2009)
  • Author(s): 喜多川浩一, 安藤雄一, 他
  • Organizer: 第47回日本癌治療学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-24
• [Presentation] 多剤併用化学療法におけるQTc間隔延長と催不整脈作用の臨床的探索 (2009)
  • Author(s): 喜多川浩一, 安藤雄一
  • Organizer: 第47回日本癌治療学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Book] がん診療のサポーティブケアガイド起こりうる症状・有害事象へのトータルマネジメント (2010)
  • Author(s): 安藤雄一(単独編集)
  • Total Pages: 256
  • Publisher: 文光堂
• [Book] がん診療のサポーティブケアガイド 起こりうる症状・有害事象へのトータルマネジメント (2010)
  • Author(s): 安藤雄一(編集)
  • Total Pages: 256
  • Publisher: 文光堂
• [Book] 外来がん化学療法マニュアル (2009)
  • Author(s): 安藤雄一(執筆および編集)
  • Total Pages: 24
  • Publisher: 文光堂