Molecular mechanism of zinc toxicity in ischemic brain
| Project/Area Number |
20590543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
HARA Hirokazu Gifu Pharmaceutical University, 薬学部, 准教授 (30305495)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Tetsuo 岐阜薬科大学, 薬学部, 教授 (40137063)
KAMIYA Tetsuro 岐阜薬科大学, 薬学部, 助教 (60453057)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Mitsuhiro 神戸薬科大学, 薬学部, 教授 (00330423)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 亜鉛 / 神経細胞死 / 神経細胞 / 脳神経疾患 / 薬学 |
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| Research Abstract |
In this study, we examined effects of zinc (Zn) on expression of BH3-only proteins, which are known as major regulators of apoptosis, in human neuroblastoma SH-SY5Y cells. We demonstrated here that Zn functions as an inducer of gene expression of these apoptotic proteins. Our findings suggest that Zn might activate cell death process via the intrinsic apoptotic pathway.
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Report
(4 results)
Research Products
(25 results)
