Metabolism of ADMA, a novel risk factor of cardiovascular diseases and its pathophysiological role
| Project/Area Number |
20590582
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
KIMOTO Masumi Okayama Prefectural University, 保健福祉学部, 教授 (40108866)
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| Co-Investigator(Kenkyū-buntansha) |
WAKINO Syu 慶應義塾大学, 医学部, 講師 (50265823)
YAMANISHI Rintaro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30253206)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Hiromi 岡山県立大学, 保健福祉学部, 教授 (70254563)
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| Research Collaborator |
YOKORO Miyuki 岡山県立大学, 大学院・保健福祉科学専攻, 博士後期課程2年
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 非対称性メチル化アルギニン / ADMA / DDAH / 一酸化窒素 / 内因性NOS阻害剤 / 動脈硬化症 / タンパク質アルギニンメチル化修飾 / 心血管疾患リスクファクター / 非対称ジチルアルギニン / 赤血球カタラーゼ / 動脈硬化 / PRMT1 / GARモチーフ / 翻訳後修飾 / 非対称ジメチルアルギニン / GAR モチーフ / 内因性NOS拮抗阻害剤 / N^6, N^6-dimethylarginine / 赤血球 / catalase |
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| Research Abstract |
We investigated the metabolic pathways of asymmetric dimethylarginine (ADMA) in blood cells to elucidate the regulatory mechanism of elevation of plasma ADMA, a novel risk factor of cardiovascular diseases. We found for the first time that ADMA was actively metabolized by PRMT1 and DDAH1 in erythrocytes and identified catalase that contains ADMA residue and interacts with PRMT1. These findings suggest that catalase is a potential target for methylation by PRMT1 in erythrocytes and may be a source of plasma ADMA.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Overexpression of dimethyl arginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.2010
Author(s)
Rodionov RN, Dayoub H, Lynch CM, Wilson KM, Stevens JW, Murry DJ, Kimoto M, Arning E, Bottiglieri T, Cooke JP, Baumbach GL, Faraci FM, Lentz SR.
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Journal Title
Circulation Res 106(3)
Pages: 551-558
Related Report
Peer Reviewed
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[Journal Article] Vascular endothelial-specific dimethylarginine di methylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.2009
Author(s)
Hu X, Xu X, Zhu G, Atzler D, Kimoto M, Chen J, Schwedhelm E, Luneburg N, Boger RH, Zhang P, Chen Y.
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Journal Title
Circulation 120(22)
Pages: 2222-2229
Related Report
Peer Reviewed
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