Searching genes susceptible for life-style related diseases, such as diabetes and hypertension.

• Project/Area Number: 20590595
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Yamagata University
• Principal Investigator: DAIMON Makoto 山形大学, 大学院・医学研究科, 准教授 (20241698)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 分子遺伝疫学 / 高畠研究 / 住民研究 / 遺伝子多型 / 2型糖尿病 / GNB3遺伝子 / 高血圧 / Clu遺伝子 / インスリン抵抗性 / 分子疫学 / 生活習慣病 / 糖尿病 / 肥満 / FTO遺伝子 / 運動量 / エネルギー摂取量 / hOGG1 / DNA修復酵素 / GNB3 / 塩分摂取量

Research Abstract

Most studies to find genes susceptible for life-style related diseases have been conducted without regard for life-style per se. This strategy conveys a risk that the results obtained were not useful in ordinary clinical settings. Therefore, we search genes susceptible for life-style related diseases with detailed information of life-styles such as nutritional intakes and physical activities, and found several genes susceptible for life-style related diseases. Of them, tow genes (GNB3 and FTO) were found as associated with diabetes in relation with salt intake and obesity in relation with physical activities, respectively. These findings seem to be very useful in ordinary clinical settings.

Research Products

• [Journal Article] Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study (2013)
  • Author(s): Kaino W, Daimon M, Sasaki S, et al.
  • Journal Title: Endocrine Journal Volume: 60 Issue: 5 Pages: 617-628
  • DOI: 10.1507/endocrj.EJ12-0351
  • NAID: 10031184529
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians (2012)
  • Author(s): Li H, Kilpelainen TO, Liu C, et al.
  • Journal Title: Diabetologia Volume: 55 Issue: 4 Pages: 981-995
  • DOI: 10.1007/s00125-011-2370-7
  • Peer Reviewed
• [Journal Article] Higher plasma renin activity is a risk factor for total mortality in older Japanese individuals: the Takahata study (2012)
  • Author(s): Daimon M, Konta T, Oizumi T, et al.
  • Journal Title: Metabolism Volume: 61 Issue: 4 Pages: 504-511
  • DOI: 10.1016/j.metabol.2011.08.004
  • Peer Reviewed
• [Journal Article] Plasma Fibrinogen, Global Cognitive Function, and Cerebral Small Vessel Disease: Results of a Cross-Sectional Study in Community-Dwelling Japanese Elderly (2011)
  • Author(s): Wada M, Takahashi Y, Iseki C, et al.
  • Journal Title: Internal Medicine Volume: 50 Issue: 9 Pages: 999-1007
  • DOI: 10.2169/internalmedicine.50.4752
  • NAID: 130000650102
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Association of the clusterin gene polymorphisms with type 2 diabetes mellitus (2011)
  • Author(s): Daimon M, Oizumi T, Karasawa S, et al.
  • Journal Title: Metabolism Volume: 60 Issue: 6 Pages: 815-822
  • DOI: 10.1016/j.metabol.2010.07.033
  • Peer Reviewed
• [Journal Article] Relationship between alcohol consumption and serum adiponectin levels: the Takahata study-a cross-sectional study of a healthy Japanese population (2010)
  • Author(s): Nishise Y, Saito T, Makino N, et al.
  • Journal Title: J Clin EndocrinolMetab Volume: 95 Issue: 8 Pages: 3828-3835
  • DOI: 10.1210/jc.2009-1862
  • Peer Reviewed
• [Journal Article] Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population (2010)
  • Author(s): Karasawa S, Daimon M, Sasaki S, et al.
  • Journal Title: Endocrine Journal Volume: 57 Issue: 4 Pages: 293-301
  • DOI: 10.1507/endocrj.K09E-305
  • NAID: 10029584254
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Cystatin C as an index of cerebral small vessel disease: results of a cross-sectional study in community-based Japanese elderly (2010)
  • Author(s): Wada M, Nagasawa H, Kawanami T, et al.
  • Journal Title: EurJ Neurol Volume: 17 Issue: 3 Pages: 383-390
  • DOI: 10.1111/j.1468-1331.2009.02809.x
  • Peer Reviewed
• [Journal Article] Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population. (2010)
  • Author(s): Karasawa, S., Daimon, M., Sasaki, S., Toriyama, S., Oizumi, T., Susa, S., Kameda, W., Wada, K., Muramatsu, M., Fukao, A., Kubota, I., Kawata, S., Kayama, T., Kato, T.
  • Journal Title: Endocr J. 57 Pages: 293-301
  • NAID: 10029584254
  • Peer Reviewed
• [Journal Article] Association of the common fat mass and obesity associated(FTO) gene polymorphism with obesity in a Japanese population. (2010)
  • Author(s): Shigeru Karasawa, Makoto Daimon, et al
  • Journal Title: Endocrine Journal Volume: 57 Pages: 293-301
  • NAID: 10029584254
  • Peer Reviewed
• [Journal Article] Impact of metabolic syndrome on elevated serum alanine aminotransferase levels in theJapanese population (2009)
  • Author(s): Saito T, Nishise Y, Makino N, et al.
  • Journal Title: Metabolism Volume: 58 Issue: 8 Pages: 1067-1075
  • DOI: 10.1016/j.metabol.2009.03.008
  • Peer Reviewed
• [Journal Article] Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM (2009)
  • Author(s): Daimon M, Oizumi T, Toriyama S, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 386 Issue: 1 Pages: 26-29
  • DOI: 10.1016/j.bbrc.2009.05.119
• [Journal Article] Association of the Ser326Cys polymorphism in the OGG1 gene with type 2DM. (2009)
  • Author(s): Daimon, M., Oizumi, T., Toriyama, S., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S., Muramatsu, M., Kubota, I., Kawata, S., Kato, T.
  • Journal Title: Biochem Biophys Res Commun. 386 Pages: 26-29
  • Peer Reviewed
• [Journal Article] Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM. (2009)
  • Author(s): Makoto Daimon, et al
  • Journal Title: Biochem Biophys Res Commun 386 Pages: 26-29
  • Peer Reviewed
• [Journal Article] Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population (2008)
  • Author(s): Daimon M, Sato H, Oizumi T, et al.
  • Journal Title: Biochem BiophysRes Commun Volume: 365 Issue: 3 Pages: 466-471
  • DOI: 10.1016/j.bbrc.2007.10.180
  • Peer Reviewed
• [Journal Article] Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations (2008)
  • Author(s): Iijima H, Emi M, Wada M, et al.
  • Journal Title: J HumGenet Volume: 53 Issue: 3 Pages: 193-200
  • DOI: 10.1007/s10038-007-0236-0
  • Peer Reviewed
• [Journal Article] A functional polymorphism of the TNF-alpha gene that is associated with type 2 DM (2008)
  • Author(s): Susa S, Daimon M, Sakabe J, et al.
  • Journal Title: Biochem BiophysRes Commun Volume: 369 Issue: 3 Pages: 943-947
  • DOI: 10.1016/j.bbrc.2008.02.121
  • Peer Reviewed
• [Journal Article] Cerebral small vessel disease and chronic kidney disease (CKD): results of a cross-sectional study in community-based Japanese elderly (2008)
  • Author(s): Wada M, Nagasawa H, Iseki C, et al.
  • Journal Title: JNeurolSci Volume: 272 Issue: 1-2 Pages: 36-42
  • DOI: 10.1016/j.jns.2008.04.029
  • Peer Reviewed
• [Journal Article] Salt consumption-dependent association of the GNB3 gene polymorphism with type 2DM (2008)
  • Author(s): Daimon M, Sato H, Sasaki S, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 374 Issue: 3 Pages: 576-580
  • DOI: 10.1016/j.bbrc.2008.07.065
  • Peer Reviewed
• [Journal Article] Genetic Association between Aldehyde Dehydrogenase 2 (ALDH2) Variation and High-Density Lipoprotein Cholesterol (HDL-C) Among Non-Drinkers in Two Large Population Samples in Japan (2008)
  • Author(s): Wada M, Daimon M, Emi M, et al.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 15 Issue: 4 Pages: 179-184
  • DOI: 10.5551/jat.E542
  • NAID: 10022608547
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM. (2008)
  • Author(s): Daimon, M., Sato, H., Sasaki, S., Toriyama, S., Emi, M., Muramatsu, M., Hunt, S.C., Hopkins, P.N., Karasawa, S., Wada, K., Jimbu, Y., Kameda, W., Susa, S., Oizumi, T., Fukao, A., Kubota, I., Kawata, S., Kato, T.
  • Journal Title: Biochem Biophys Res Commun. 374 Pages: 576-580
  • Peer Reviewed
• [Journal Article] Association of the PIK3C2G gene polymorphisms with type 2DM in a Japanese population (2008)
  • Author(s): Daimon, M., Sato, H., Oizumi, T., Toriyama, S., Saito, T., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S., Yamaguchi, H., Emi, M., Muramatsu, M., Kubota, I., Kawata, S., Kato, T.
  • Journal Title: Biochem Biophys Res Commun. 365 Pages: 466-471
  • Peer Reviewed
• [Journal Article] Salt consumption-dependent association of the GNB3 gene poly-morphism with type 2 diabetes (2008)
  • Author(s): Makoto Daimon
  • Journal Title: Biochemical and Biophysical Research Communications 374 Pages: 276-580
  • Peer Reviewed
• [Journal Article] Association of the PIK3C2G gene polymorphisms with type 2 diabetes in a Japanese population (2008)
  • Author(s): Makoto Daimon
  • Journal Title: Biochemical and Biophysical Research Communications 365 Pages: 466-471
  • Peer Reviewed
• [Presentation] Decreased physical activity is associated with a clustering of metabolic risk factors in non-obese and obese Japanese subjects. (2012)
  • Author(s): Kaino W, et al.
  • Organizer: 9^<th> International Diabetes Federation-Western Pacific Region Meeting
  • Place of Presentation: 京都国際会館
  • Year and Date: 2012-11-25
• [Presentation] Decreased physical activity is associated with a clustering of metabolic risk factors in non-obese and obese Japanese subjects (2012)
  • Author(s): Kaino W, et al
  • Organizer: 9^<th> International Diabetes Federation-Western Pacific Region Meeting,Kyoto
  • Place of Presentation: 京都国際会館
  • Year and Date: 2012-11-02
• [Presentation] 動脈硬化性疾患の危険因子の重積は身体活動量と関連している (2012)
  • Author(s): 海野航, 他
  • Organizer: 第55回日本糖尿病会年次学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2012-05-18
• [Presentation] 動脈硬化性疾患の危険因子の重積は身体活動量と関連している (2012)
  • Author(s): 海野航, 他
  • Organizer: 第55回日本糖尿病会年次学術集会
  • Place of Presentation: パシフィコ横浜国際会議場
  • Year and Date: 2012-05-18
• [Presentation] 血漿レニン活性高値は全死亡の危険因子 (2012)
  • Author(s): 大門真, 他
  • Organizer: 第85回日本内分泌学会年次学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-04-19
• [Presentation] 5年後の糖尿病発症リスクを指標とした耐糖能の評価基準の検討 (2011)
  • Author(s): 大門真, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市教育文化会館
  • Year and Date: 2011-05-20
• [Presentation] 地域住民における耐糖能障害と悪性新生物発症との関連 (2011)
  • Author(s): 大泉俊英, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市教育文化会館
  • Year and Date: 2011-05-19
• [Presentation] MI標準高値は耐糖能異常、脂質異常、高血圧の危険因子である (2010)
  • Author(s): 和田輝里子, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: ラヴィール岡山
  • Year and Date: 2010-05-29
• [Presentation] BMI標準高値は耐糖能異常、脂質異常、高血圧の危険因子である (2010)
  • Author(s): 和田輝里子、大門真, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市デジタルミュージアム
  • Year and Date: 2010-05-29
• [Presentation] Fat mass and obesityassociated (FTO)遺伝子多型は肥満と運動量依存性に関連している (2010)
  • Author(s): 柄澤繁, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: ラヴィール岡山
  • Year and Date: 2010-05-28
• [Presentation] Fat mass and obesity associated (FTO)遺伝子多型は肥満と運動量依存性に関連している. (2010)
  • Author(s): 柄澤繁, 海野航, 高瀬薫, 多田杏子, 神部裕美, 和田輝里子, 亀田亘, 諏佐真治, 大泉俊英, 大門真, 加藤丈夫
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-28
• [Presentation] Fat mass and obesity associated(FTO)遺伝子多型は肥満と運動量依存性に関連している (2010)
  • Author(s): 柄澤繁、大門真, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: ラヴィール岡山
  • Year and Date: 2010-05-28
• [Presentation] Clusterin/apolipoproteinJ遺伝子多型と 2型糖尿病との関連 (2010)
  • Author(s): 大門真, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Presentation] Clusterin/apolipoprotein J遺伝子多型と2型糖尿病との関連. (2010)
  • Author(s): 大門真, 大泉俊英, 柄澤繁, 海野航, 高瀬薫, 多田杏子, 神部裕美, 和田輝里子, 亀田亘, 諏佐真治, 村松正明, 加藤丈夫
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Presentation] 糖尿病発症と関連性を示した Microsomal glutathioneS-transferase 1 (MGST1)遺伝子の疫学的解析 (2009)
  • Author(s): 諏佐真治, 他
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-05-29
• [Presentation] 糖尿病発症と関連性を示したMicrosomal glutathione S-transferase 1 (MGST1) 遺伝子の疫学的解析. (2009)
  • Author(s): 諏佐真治, 柄澤繁, 和田輝里子, 神部裕美, 亀田亘, 大泉俊英, 平田昭彦, 大門真, 加藤丈夫
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-29
• [Presentation] Human 8-oxoguanin DNAglycosylase (hOGG1)遺伝子多型は 2型糖尿病と関連している (2009)
  • Author(s): 大門真, 他
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-05-24
• [Presentation] Human 8-oxoguanin DNA glycosylase (hOGG1) 遺伝子多型は2型糖尿病と関連している-舟形研究- (2009)
  • Author(s): 大門真, 大泉俊英, 和田輝里子, 柄澤繁, 神部裕美, 亀田亘, 諏佐真治, 平田昭彦, 村松正明, 加藤丈夫
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-24
• [Presentation] Human 8-oxoguanin DNA glycosylase(hOGG1)遺伝子多型は2型糖尿病と関連している-舟形研究- (2009)
  • Author(s): 大門眞, 他
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-05-24
• [Presentation] GNB3遺伝子C825T多型は食塩摂取量依存性に2型糖尿病の危険因子となっている (2008)
  • Author(s): 大門真, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-05-23
• [Presentation] GNB3遺伝子C825T多型は食塩摂取量依存性に2型糖尿病の危険因子となっている. (2008)
  • Author(s): 大門真, 柄澤繁, 神部裕美, 和田輝里子, 亀田亘, 諏佐真治, 大泉俊英, 山口宏, 江見充, 深尾彰, 加藤丈夫
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Remarks]
  • URL: http://minfo.id.yamagata-u.ac.jp/naika3/index.html