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Regulatory mechanisms of macrophage differentiation in crosstalk between obesity and inflammation : the application to metabolic syndrome

Research Project

Project/Area Number 20590614
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKyorin University

Principal Investigator

KIZAKI Takako  Kyorin University, 医学部, 教授 (00322446)

Co-Investigator(Kenkyū-buntansha) OHNO Hideki  杏林大学, 医学部, 教授 (00133819)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords炎症反応 / マクロファージ / 肥満 / 生活習慣病 / 運動トレーニング / 炎症性反応 / 一酸化窒素合成酵素 / 炎症性サイトカイン / 一酸化窒素 / アドレナリン受容体
Research Abstract

β2-adrenergic receptor (β2AR) suppresses inflammatory responses in macrophages. Toll-like receptor 4 stimulation inhibitsβ2AR expression, resulting in enhanced inflammatory responses. Exercise training down-regulates the low-glade inflammation under high fat diet obesity by ghrelin which is expressed in macrophages.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (134 results)

All 2011 2010 2009 2008 Other

All Journal Article (47 results) (of which Peer Reviewed: 43 results) Presentation (70 results) Book (17 results)

  • [Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes.2011

    • Author(s)
      Ogasawara, J., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 402 Pages: 554-559

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes.2010

    • Author(s)
      Ogasawara J., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Biochem.Biophys.Res.Commun. 400

      Pages: 134-139

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin.2010

    • Author(s)
      Miyazaki S., Kizaki T., Ohno H., et al. H., 他
    • Journal Title

      Life Sci.

      Pages: 691-698

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise intensity and antioxidant ability.2010

    • Author(s)
      Nagasawa J., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Rejuv.Res.

      Pages: 172-174

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes.2010

    • Author(s)
      Ogasawara, J., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 400 Pages: 134-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes.2010

    • Author(s)
      Ogasawara, J., et al.
    • Journal Title

      Phytother.Res.

      Volume: 250 Pages: 467-471

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue.2010

    • Author(s)
      Sakurai, T., et al.
    • Journal Title

      Acta Physiol.(Oxf)

      Volume: 200 Pages: 325-338

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低圧・低酸素環境が引き起こす酸化ストレスとオリゴノールの抗酸化効果2010

    • Author(s)
      長澤純一, 他
    • Journal Title

      登山医学

      Volume: 30 Pages: 118-124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      大野秀樹, 他
    • Journal Title

      からだと温度の事典(朝倉書店)

      Pages: 516-517

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      大野秀樹
    • Journal Title

      『日本臨床』:2010年増刊肥満症[第2版]-基礎・臨床研究の進歩-(日本臨床社)

      Pages: 272-276

    • Related Report
      2009 Annual Research Report
  • [Journal Article] β_2-Adrenergic receptor regulate Toll-like receptor 4-induced late-phase NF-kB activation.2009

    • Author(s)
      Kizaki T., Shirato K., Ohno H.,et al., 他
    • Journal Title

      Mol.Immunol. 46

      Pages: 1195-1203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in co-culture of adipocytes and macrophages.2009

    • Author(s)
      Sakurai T., Kizaki T., Ohno H., et al., 他
    • Journal Title

      J.Nutr.Biochem. 21

      Pages: 47-54

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue2009

    • Author(s)
      Sakurai T., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 605-609

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Swimming training prevents induction of suppressor macrophages in mice during acute exposure to cold.2009

    • Author(s)
      Ohno H., Haga S., Kizaki T., et al., 他
    • Journal Title

      Adv.Exerc.Sports Physiol. 15

      Pages: 1-7

    • NAID

      110007330710

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway.2009

    • Author(s)
      Ogasawara J., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Phytother.Res. 23

      Pages: 1626-1633

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-inducible factor-1α suppresses the expression of macrophage scavenger receptor 1.2009

    • Author(s)
      Shirato K., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Pfluers Arch. 459

      Pages: 93-103

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages2009

    • Author(s)
      Sakurai, T., et al.
    • Journal Title

      J Nutr.Biochem. 21

      Pages: 47-54

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-inducible factor-1 α suppresses the expression of macrophage scavenger receptor 12009

    • Author(s)
      Shirato, K., et al.
    • Journal Title

      Pflugers Arch. 459

      Pages: 93-103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway2009

    • Author(s)
      Ogasawara, J., et al.
    • Journal Title

      Phytother. Res. 23

      Pages: 1626-1633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swimming training prevents induction of suppressor macrophages in mice during acute exposure to cold2009

    • Author(s)
      Ohno, H., et al.
    • Journal Title

      Adv.Exerc.Sports Physiol. 15

      Pages: 1-7

    • NAID

      110007330710

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue2009

    • Author(s)
      Sakurai, T., et al.
    • Journal Title

      Biochem. Biophys. Res.Commun. 379

      Pages: 605-609

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      大野秀樹, 他
    • Journal Title

      登山の医学ハンドブック(杏林書院)

      Pages: 92-95

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      大野秀樹
    • Journal Title

      『臨床スポーツ医学』2009年臨時増刊号スポーツ栄養・食事ガイド[競技力向上とコンディショニングのためのスポーツ栄養学](文光堂)

      Pages: 166-173

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue2009

    • Author(s)
      Sakurai, T., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 379

      Pages: 605-609

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages2009

    • Author(s)
      Sakurai, T., et al.
    • Journal Title

      J. Nutr. Biochem. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swimming training prevents induction of suppressor macrophages in mice during acute exposure to cold2009

    • Author(s)
      Ohno, H., et al.
    • Journal Title

      Adv. Exerc. Sports Physiol. (in press)

    • NAID

      110007330710

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Adrenergic receptor regulates Toll-like receptor 4-induced TRIF-dependent late-phase NF-κB activation2009

    • Author(s)
      Kizaki, T., et al.
    • Journal Title

      Mol. Immunol. 46

      Pages: 1195-1203

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Oligonol, low-molecular form of lychee fruit-derived polyphenol, on lipolysis in pnmary rat adipocytes2009

    • Author(s)
      Ogasawara, J., et al
    • Journal Title

      Phytother. Res. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β_2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-κB activation through β-arrestin 2.2008

    • Author(s)
      Kizaki T., Izawa T., Ohno H., et al., 他
    • Journal Title

      Immunology 124

      Pages: 348-356

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of macrophages to exercise training improves innate immunity.2008

    • Author(s)
      Kizaki T., Takemasa T., Ohno H., et al., 他
    • Journal Title

      Biochem.Biophys.Res.Commun. 372

      Pages: 152-156

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute exercise induces biphasic increase in respiratory mRNA in skeletal muscle.2008

    • Author(s)
      Ikeda S., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Biochem.Biophys.Res.Commun. 368

      Pages: 323-328

    • NAID

      120007138838

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of pollen dispersion in the neighborhood of Tokyo, Japan in the spring of 2005 and 2006.2008

    • Author(s)
      Ishibashi Y., Ohno H., Kizaki T., et al., 他
    • Journal Title

      Int.J.Environ.Res.Public Health 5

      Pages: 76-85

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta.2008

    • Author(s)
      Hitomi Y., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Redox Rep. 13

      Pages: 213-216

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The supplementation of Oligonol, the new lychee furit-derived polyphenol converting into a low-molecular form, has a positive effect on fatigue during regular track- and field-training in young athletes.2008

    • Author(s)
      Ohno H., Sakurai T., Kizaki T., et al., 他
    • Journal Title

      Adv.Exerc.Sports Physiol. 13

      Pages: 93-99

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidative effects of a new lychee fruit-derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes.2008

    • Author(s)
      Sakurai T., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Biosci.Biotechnol.Biochem. 72

      Pages: 463-476

    • NAID

      10027524397

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of macrophages to exercise training improves innate immunity2008

    • Author(s)
      Kizaki, T., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 372

      Pages: 152-156

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute exercise induces biphasic increase in respiretory mRNA in skeletal muscle2008

    • Author(s)
      Ikeda, S., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 368

      Pages: 323-328

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JNK-and IκB-dependent pathways regulate MCP-1, not adiponectin, release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro2008

    • Author(s)
      Takahashi, K., et al.
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab. 294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta2008

    • Author(s)
      Hitomi, Y., et al
    • Journal Title

      Redox Rep. 13

      Pages: 213-216

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The supplementation of Oligonol, the new lychee fruit-derived polyphenol converting into a low-molecular form, Has a positive effect on fatigue during regular track- and- field training in young athletes2008

    • Author(s)
      Ohno, H., et al.
    • Journal Title

      Adv. Exerc. Sports Physiol. 13

      Pages: 93-99

    • NAID

      110006632543

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-κB activation through β-arrestin 22008

    • Author(s)
      Kizaki, T., et al.
    • Journal Title

      Immunology 124

      Pages: 348-356

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes.

    • Author(s)
      Ogasawara J., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Phytother.Res. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats.

    • Author(s)
      Hatano D., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Scand.J.Med.Sci.Sports (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue.

    • Author(s)
      Sakurai T., Kizaki T., Ohno H., et al., 他
    • Journal Title

      Acta Physiol (Oxf). (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats.

    • Author(s)
      Hatano, D., et al.
    • Journal Title

      Scand.J.Med.Sci.Sports

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin

    • Author(s)
      Miyazaki, S., et al.
    • Journal Title

      Life Sci. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise intensity and antioxidant ability

    • Author(s)
      Nagasawa, J., et al.
    • Journal Title

      Rejuvenation Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The lipolytic activity in adipocytes differs between normal and high fat diet mice via changes in the trafficking of β_2-adrenergic receptor.2011

    • Author(s)
      Ogasawara J., et al.
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] The lipolytic activity in adipocytes differs between normal and high fat diet mice via changes in the trafficking of β_2-adrenergic receptor2011

    • Author(s)
      Ogasawara, J., et al.
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスビタミンC代謝に対する急性運動の影響2011

    • Author(s)
      人見嘉哲, 他
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 肥満抑制効果を有するOligonolによる脂肪分解反応の調節機構の解明2011

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第81回に日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満抑制効果を有するOligonolによる脂肪分解反応の調節機構の解明2011

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 運動およびOligonolの摂取は老化促進モデルマウスの認知機能障害を予防する2011

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第81回に日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動およびOligonolの摂取は老化促進モデルマウスの認知機能障害を予防する2011

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 老化促進モデルマウスの認知機能障害に対するOligonolの予防効果2010

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第8回日本予防医学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2010-12-12
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新規低分子かポリフェノール(Oligonol)による脂肪分解反応の調節メカニズム2010

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第39回杏林医学会総会
    • Place of Presentation
      三鷹
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 老化促進モデルマウスの認知機能障害に対する運動トレーニング効果2010

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      市川
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 持久運動トレーニングによる脂肪細胞のATGL発現変化と調節メカニズム2010

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第18回日本運動生理学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 持久運動トレーニングによる脂肪細胞のATGL発現変化と調節メカニズム.第18回日本運動生理学会大会2010

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第18回日本運動生理学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-08-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Both Oligonol and exercise have preventive effects on cognitive impairment in senescence-accelerated mice.2010

    • Author(s)
      Sakurai T., et al.
    • Organizer
      8th International Congress on Nutrition and Integrative Medicine.
    • Place of Presentation
      Sapporo
    • Year and Date
      2010-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Both Oligonol and exercise have preventive effects on cognitive impairment in senescence-accelerated mice.2010

    • Author(s)
      Sakurai, T., et al.
    • Organizer
      18th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Sapporo
    • Year and Date
      2010-07-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oligonol, a new lychee fruit-derived low molecular form of polyphenol, enhances lipolysis in primary rat adipocytes via adtivation of the ERK1/2 pathway.2010

    • Author(s)
      Ogasawara J., et al.
    • Organizer
      11th International Congress on Obesity.
    • Place of Presentation
      Stochholm
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 運動および新規低分子化ポリフェノールOligonolによる脂肪組織酸化ストレス軽減効果2010

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第80回日本衛生学会総会:連携研究会酸化ストレス研究会シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-11
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応とAdipose Triglyceride Lipaseの役割2010

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第80回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応とAdipose Trigly ceride Lipaseの役割2010

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第80回日本衛生学会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 運動トレーニングによる肥満・生活習慣病および認知症予防効果とそのメカニズム2010

    • Author(s)
      櫻井拓也, 他
    • Organizer
      文部科学省学術フロンテイア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第4回研究会
    • Place of Presentation
      所沢
    • Year and Date
      2010-01-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 文部科学省学術フロンテイア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」2010

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第4回研究会
    • Place of Presentation
      所沢
    • Year and Date
      2010-01-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動トレーニングによる肥満・生活習慣病および認知症予防効果とそのメカニズム2010

    • Author(s)
      櫻井拓也, 他
    • Organizer
      文部科学省学術フロンテイア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第4回研究会
    • Place of Presentation
      早稲田大学所沢キャンパス(埼玉県)
    • Year and Date
      2010-01-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂肪代謝に及ぼす新規低分子化ポリフェノール(Oligonol)の効果と作用機序2010

    • Author(s)
      小笠原準悦, 他
    • Organizer
      文部科学省学術フロンテイア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第4回研究会
    • Place of Presentation
      早稲田大学所沢キャンパス(埼玉県)
    • Year and Date
      2010-01-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] ワークショップ"マクロファージシグナル伝達":Hypoxia-inducible factor-1α suppresses the expression of macrophage scavenger receptor 1.2009

    • Author(s)
      木崎節子, 他
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Hypoxia-inducible factor-1α suppresses the expression of macrophage scavenger receptor 12009

    • Author(s)
      Kizaki, T., et al.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞分化を抑制する効果をもつ2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第38回杏林医学会総会
    • Place of Presentation
      三鷹
    • Year and Date
      2009-11-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞分化を抑制する効果をもつ2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第38回杏林医学会総会
    • Place of Presentation
      杏林大学三鷹キャンパス(東京都)
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 運動をプローブとしたアルツハイマー型認知症予防に対する新規ターゲット分子の検索2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第38回杏林医学会総会
    • Place of Presentation
      杏林大学三鷹キャンパス(東京都)
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応の亢進にはadipose triglyceride lipase(ATGL)の発現変化が関与する2009

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応の亢進にはadipose triglycerde lipoase(ATGL)の発現変化が関与する2009

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪組織由来幹細胞の脂肪細胞分化に及ぼす運動トレーニングの影響2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪細胞サイズに依存したアディポカイン遺伝子発現に及ぼす運動トレーニングの影響2009

    • Author(s)
      井澤鉄也, 他
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪細胞サイズに依存したアデイポカイン遺伝子発現に及ぼす運動トレーニングの影響2009

    • Author(s)
      井澤鉄也, 他
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂肪組織由来幹細胞の脂肪細胞分化に及ぼす運動トレーニングの影響2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hypoxia-inducible factor-1a regulates expression of mRNA for Macrophage scavenger receptor 1.2009

    • Author(s)
      Shirato K., et al.
    • Organizer
      36th International Congress of Physiological Sciences.
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Hypoxia-inducible factor-1 α regulates expression of mRNA for macrophage scavenger receptor 12009

    • Author(s)
      Shirato, K., et al.
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto International Conference Center(Kyoto)
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性運動は脂肪細胞の脂肪分解反応をどのように調節するのか2009

    • Author(s)
      前川剛輝, 他
    • Organizer
      第17回日本運動生理学会大会
    • Place of Presentation
      東京慈恵会医科大学西新橋校(東京都)
    • Year and Date
      2009-07-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂肪組織由来幹細胞の脂肪細胞への分化は運動トレーニングによって抑制される2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第17回日本運動生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪組織由来幹細胞の脂肪細胞への分化は運動トレーニングによって抑制される2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第17回日本運動生理学会大会
    • Place of Presentation
      東京慈恵会医科大学西新橋校(東京都)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] The signal transduction pathway of Oligonol-induced phosphorylation on ERK1/2 in primary rat adipocytes2009

    • Author(s)
      Ogasawara, J., et al.
    • Organizer
      17th International Symposium of AHCC Research Association
    • Place of Presentation
      Royton Sappro(Hokkaido)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素誘導因子(HIF)-1αはマクロファージスカベンジャー受容体1の発現を抑制する2009

    • Author(s)
      大野秀樹, 他
    • Organizer
      第29回日本登山医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 低酸素誘導因子(HIF)-1αはマクロファージスカベンジャー受容体1の発現を抑制する2009

    • Author(s)
      大野秀樹, 他
    • Organizer
      第29回日本登山医学会学術集会
    • Place of Presentation
      東京コンファレンスセンター品川(東京都)
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] New lychee fruit-derived polyphenol Oligonol converted into a low-molecular form improves exercise-induced fatigue2009

    • Author(s)
      Sakurai, T., et al.
    • Organizer
      3eme Symposium Nutrition, Biologie de I'Oxygene et Medecine-Paris 2009
    • Place of Presentation
      Campus des Cordeliers(France)
    • Year and Date
      2009-04-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂肪組織由来幹細胞の脂肪および血管内皮細胞への分化に対する運動トレーニングの影響2009

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第79回日本衛生学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性運動による脂肪細胞の脂肪分解反応のメカニズム2009

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第79回日本衛生学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] マクロファージスカベンジャー受容体1の発現はHIF-1αによって調節される2009

    • Author(s)
      白土健, 他
    • Organizer
      第145回日本体力医学会関東地方会
    • Place of Presentation
      三鷹
    • Year and Date
      2009-03-14
    • Related Report
      2010 Final Research Report
  • [Presentation] マクロファージスカベンジャー受容体1の発現はHIF-lαによって調節される2009

    • Author(s)
      白土健ら
    • Organizer
      第145回日本体力医学会関東地方会
    • Place of Presentation
      三鷹市
    • Year and Date
      2009-03-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動や運動トレーニングによるβ-アドレナリン受容体の適応機構2009

    • Author(s)
      井澤鉄也ら
    • Organizer
      第23回日本体力医学会近畿地方会
    • Place of Presentation
      吹田市
    • Year and Date
      2009-01-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動トレーニングによる免疫機能の修飾:マクロファージを中心として2009

    • Author(s)
      木崎節子, 他
    • Organizer
      文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
    • Place of Presentation
      所沢
    • Year and Date
      2009-01-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 低酸素誘導因子(HIF)-1αによるマクロファージスカベンジャー受容体の発現調節2009

    • Author(s)
      白土健, 他
    • Organizer
      文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
    • Place of Presentation
      所沢
    • Year and Date
      2009-01-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪細胞サイズとアデイポカイン遺伝子発現との関係に及ぼす運動トレーニングの影響2009

    • Author(s)
      井澤鉄也, 他
    • Organizer
      文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
    • Place of Presentation
      所沢
    • Year and Date
      2009-01-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 低酸素誘導因子(HIF)-1αによるマクロファージスカベンジャー受容体の発現調節2009

    • Author(s)
      白土健ら
    • Organizer
      文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
    • Place of Presentation
      所沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動トレーニングによる免疫機能の修飾 : マクロファージを中心として2009

    • Author(s)
      木崎節子ら
    • Organizer
      文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
    • Place of Presentation
      所沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪細胞サイズとアデイポカイン遺伝子発現との関係に及ぼす運動トレーニングの影響2009

    • Author(s)
      井澤鉄也ら
    • Organizer
      文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
    • Place of Presentation
      所沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 急性運動による脂肪細胞の脂肪分解反応のメカニズム2009

    • Author(s)
      小笠原準悦ら
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪組織由来幹細胞の脂肪および血管内皮細胞への分化に対する運動トレーニングの影響2009

    • Author(s)
      櫻井拓也ら
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] New lychee fruit-derived polyphenol Oligonol converted into a low-molecular form improves exercise-induced fatigue2009

    • Author(s)
      Sakurai, T., et al
    • Organizer
      3rd Symposium of Nutrition, 0xygen Biology and Medicine
    • Place of Presentation
      Paris
    • Related Report
      2008 Annual Research Report
  • [Presentation] 急性運動と脂肪細胞のホルモン感受性リポーゼの発現変化2008

    • Author(s)
      小笠原準悦, 他
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府
    • Year and Date
      2008-09-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動負荷パターンの差異が酸化ストレスにおよぼす影響2008

    • Author(s)
      長澤純一, 他
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府
    • Year and Date
      2008-09-19
    • Related Report
      2010 Final Research Report
  • [Presentation] β作動性脂質代謝とユビキチン2008

    • Author(s)
      小笠原準悦
    • Organizer
      第1回脳・神経・内分泌から運動の意義を考える会
    • Place of Presentation
      別府
    • Year and Date
      2008-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] β作動性脂質代謝とユビキチン2008

    • Author(s)
      小笠原準悦ら
    • Organizer
      第1回脳・神経・内分泌から運動の意義を考える会
    • Place of Presentation
      別府市
    • Year and Date
      2008-09-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Oligolol on lipolysis in primary rat adipocytes.2008

    • Author(s)
      Ogasawara J., et al.
    • Organizer
      Functional Polyphenol Symposium on Novel Use of Low Molecular Polyphenol : Oligonol
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット初代培養脂肪細胞の脂肪分解反応に及ぼすオリゴノールの効果2008

    • Author(s)
      小笠原準悦ら
    • Organizer
      Functional Polyphenol Symposium : Novel Use of LowMolecular Polyphenol : Oligonol
    • Place of Presentation
      札幌市
    • Year and Date
      2008-07-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞への分化を抑制する2008

    • Author(s)
      櫻井拓也, 他
    • Organizer
      第6回日本予防医学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] ライチ由来新規低分子化ポリフェノールOligonolは疲労改善効果をもつ2008

    • Author(s)
      櫻井拓也ら
    • Organizer
      国際食品機能学会2008
    • Place of Presentation
      東京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 急性運動と脂肪細胞のホルモン感受性リパーゼの発現変化2008

    • Author(s)
      小笠原準悦ら
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動負荷パターンの差異が酸化ストレスにおよぼす影響2008

    • Author(s)
      長澤純一ら
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動強度の差異と酸化ストレス2008

    • Author(s)
      高井俊秀ら
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 一過性持久性運動による血管新生関連因子の発現変化2008

    • Author(s)
      町田正直ら
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞への分化を抑制する2008

    • Author(s)
      櫻井拓也ら
    • Organizer
      第6回日本予防医学会学術総会
    • Place of Presentation
      東京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨格筋に対するin vivo遺伝子導入法によるcalcineurin制御タンパクRcanl発現制御の検討2008

    • Author(s)
      人見嘉哲ら
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸市
    • Related Report
      2008 Annual Research Report
  • [Book] 『日本臨床』:2010年増刊肥満症[第2版]-基礎・臨床研究の進歩-(β_3アドレナリン受容体)2010

    • Author(s)
      大野秀樹、櫻井拓也、小笠原準悦、前川剛輝、木崎節子
    • Publisher
      日本臨床社、東京
    • Related Report
      2010 Final Research Report
  • [Book] からだと温度の事典(運動時の体温と活性酸素 彼末一之監修)2010

    • Author(s)
      大野秀樹、木崎節子
    • Publisher
      朝倉書店、東京
    • Related Report
      2010 Final Research Report
  • [Book] からだと温度の事典2010

    • Author(s)
      大野秀樹, 他
    • Total Pages
      640
    • Publisher
      朝倉書店
    • Related Report
      2010 Annual Research Report
  • [Book] 運動と免疫2009

    • Author(s)
      大野秀樹、木崎節子編
    • Total Pages
      420
    • Publisher
      ナップ、東京
    • Related Report
      2010 Final Research Report
  • [Book] 改訂第2版登山の医学ハンドブック(日本登山医学研究会編)(松林公蔵監 紫外線障害(日焼け、雪盲))2009

    • Author(s)
      大野秀樹、木崎節子
    • Publisher
      杏林書院、東京
    • Related Report
      2010 Final Research Report
  • [Book] 運動と免疫(大野秀樹、木崎節子編)(運動と自然免疫)2009

    • Author(s)
      木崎節子、渡辺憲治
    • Publisher
      ナップ、東京
    • Related Report
      2010 Final Research Report
  • [Book] 運動と免疫(大野秀樹、木崎節子編)(運動とマクロファージ)2009

    • Author(s)
      木崎節子、芳賀脩光、大野秀樹
    • Publisher
      ナップ、東京
    • Related Report
      2010 Final Research Report
  • [Book] 運動と免疫(大野秀樹、木崎節子編)(運動と樹状細胞)2009

    • Author(s)
      石橋義永、木崎節子、芳住邦雄
    • Publisher
      ナップ、東京
    • Related Report
      2010 Final Research Report
  • [Book] 運動と免疫(大野秀樹、木崎節子編)(運動と褐色脂肪組織と免疫)2009

    • Author(s)
      大野秀樹、木崎節子、芳賀脩光
    • Publisher
      ナップ、東京
    • Related Report
      2010 Final Research Report
  • [Book] 運動と免疫(大野秀樹、木崎節子編)(運動と寒冷環境と免疫)2009

    • Author(s)
      木崎節子、前川剛輝
    • Publisher
      ナップ、東京
    • Related Report
      2010 Final Research Report
  • [Book] 『臨床スポーツ医学』2009年臨時増刊号スポーツ栄養・食事ガイド[競技力向上とコンディショニングのためのスポーツ栄養学](酸化ストレス)2009

    • Author(s)
      大野秀樹、木崎節子
    • Publisher
      文光堂、東京
    • Related Report
      2010 Final Research Report
  • [Book] 運動と免疫からだをまもる運動のふしぎ2009

    • Author(s)
      大野秀樹、木崎節子編
    • Total Pages
      420
    • Publisher
      ナップ
    • Related Report
      2009 Annual Research Report
  • [Book] 登山の医学ハンドブック2009

    • Author(s)
      大野秀樹ら
    • Publisher
      杏林書院(印刷中)
    • Related Report
      2008 Annual Research Report
  • [Book] 運動療法と運動処方身体活動・運動支援を効果的に進めるための知識と技術第2版(佐藤祐造編)(活性酸素・フリーラジカル)2008

    • Author(s)
      大野秀樹、木崎節子
    • Publisher
      文光堂、東京
    • Related Report
      2010 Final Research Report
  • [Book] Proc. of Functional Polyphenol Symposium : Novel Use of Low Molecular Polyphenol : Oligonol2008

    • Author(s)
      小笠原準悦ら
    • Total Pages
      77
    • Publisher
      AHCC Research Association
    • Related Report
      2008 Annual Research Report
  • [Book] 運動療法と運動処方 第2版2008

    • Author(s)
      大野秀樹ら
    • Total Pages
      404
    • Publisher
      文光堂
    • Related Report
      2008 Annual Research Report
  • [Book] からだと温度の事典(彼末一之監 運動時の体温と活性酸素)

    • Author(s)
      大野秀樹、木崎節子
    • Publisher
      朝倉書店、東京
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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