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A prospective cohort study for sleep-disordered breathing and the progress of carotid atherosclerosis

Research Project

Project/Area Number 20590634
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionEhime University

Principal Investigator

SAKURAI Susumu  Ehime University, 大学院・医学系研究科, 講師 (50375515)

Co-Investigator(Kenkyū-buntansha) TANIGAWA Takeshi  愛媛大学, 大学院・医学系研究科, 教授 (80227214)
SAITO Isao  愛媛大学, 大学院・医学系研究科, 准教授 (90253781)
KITAMURA Akihiko  大阪府立健康科学センター, 健康開発部, 部長 (80450922)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords睡眠呼吸障害 / コホート研究 / パルスオキシメトリ法 / フローセンサ法 / 頚動脈エコー検査 / 動脈硬化 / コホート調査 / 心筋梗塞 / 脳梗塞
Research Abstract

Sleep-disordered breathing (SDB) is characterized by repeated episodes of partial and/or complete airway obstruction during sleep. Recent several clinical studies have indicated that patients with SDB are at increased risk for cardiovascular diseases. But few studies have been described epidemiological study in Japanese. Therefore, we conducted a cohort study to evaluate the progress of cardiovascular atherosclerosis and an effect of the severity of SDB and highly high-sensitive CRP among Japanese.
In conclusion, the undiagnosed or untreated SDB suggest the cause for the progress of cardiovascular atherosclerosis among Japanese.

Report

(3 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (18 results) Book (7 results) Remarks (6 results)

  • [Journal Article] 睡眠医療専門機関受診者における睡眠呼吸障害と交通事故との関連2010

    • Author(s)
      櫻井進、大平哲也、前田均、津田徹、成井浩司、吉田良子、谷川武
    • Journal Title

      厚生の指標 57

      Pages: 6-13

    • NAID

      40017087061

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-cultural comparison of the sleep-disordered breathing prevalence among Americans and Japanese2010

    • Author(s)
      Yamagishi K, Ohira T, Nakano H, Bielinski SJ, Sakurai S, Imano H, Kiyama M, Kitamura A, Sato S, Konishi M, Shahar E, Folsom AR, Iso H, Tanigawa T.
    • Journal Title

      Eur Respir J. Jan 28(E Pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocturnal Intermittent Hypoxia and Metabolic Syndrome ; the Effect of being Overweight : the CIRCS Study2010

    • Author(s)
      Muraki I, Tanigawa T, Yamagishi K, Sakurai S, Ohira T, Imano H, Kiyama M, Kitamura A, Sato S, Shimamoto T, Konishi M, Iso H.
    • Journal Title

      J Atheroscler Thromb. Jan 26(E Pub)

    • NAID

      130004444431

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocturnal intermittent hypoxia and the development of type 2 diabetes : the Circulatory Risk in Communities Study(CIRCS)2010

    • Author(s)
      Muraki I, Tanigawa T, Yamagishi K, Sakurai S, Ohira T, Imano H, Kitamura A, Kiyama M, Sato S, Shimamoto T, Konishi M, Iso H; CIRCS Investigators
    • Journal Title

      Diabetologia 53

      Pages: 481-488

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships of soluble E-selectin and high-sensitivity C-reactive protein with carotid atherosclerosis in Japanese men.2009

    • Author(s)
      Sakurai S, Kitamura A, Cui R, Yamagishi K, Tanigawa T, Iso H.
    • Journal Title

      J Atheroscler Thromb. 16(4)

      Pages: 339-345

    • NAID

      10025766117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for snoring among Japanese men and women : a community-based cross-sectional study2009

    • Author(s)
      Nagayoshi M, Yamagishi K, Tanigawa T, Sakurai S, Kitamura A, Kiyama M, Imano H, Ohira T, Sato S, Sankai T, Iso H; for the CIRCS Investigators
    • Journal Title

      Steep Breath. Dec 29(E Pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations between weight change since 20 years of age and sleep-disordered breathing among male truck drivers2009

    • Author(s)
      Cui R, Tanigawa T, Nakano H, Sakurai S, Yamagishi K, Ohira T, Iso H.
    • Journal Title

      Int J Obes(Lond) 33

      Pages: 1396-1401

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships of soluble E-selectin and high-sensitivity C-reactive protein with carotid atherosclerosis in Japanese men2009

    • Author(s)
      Sakurai S, Kitamura A, Cui R, Yamagishi K, Tanigawa T, Iso H.
    • Journal Title

      J Atheroscler Thromb 16

      Pages: 339-345

    • NAID

      10025766117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of cardiovascular risk factors with carotid atherosclerosis in middle-aged Japanesemen with metabolic syndrome2008

    • Author(s)
      Kirii K, Tanaka S, Yamagishi K, Iso H, Sakurai S, Tanigawa T
    • Journal Title

      Ind Health 46

      Pages: 607-612

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] SDB/SASと労働安全衛生対策シンポジウムシンポジスト2010

    • Author(s)
      谷川武
    • Organizer
      職域におけるSDB/SASスクリーニングの現状と課題.睡眠呼吸障害研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 地域・職域の健康管理活動から睡眠時無呼吸症候群を検出する意識に関する検討2010

    • Author(s)
      淡野桜子、谷川武、得居靖正、岡靖哲、櫻井進、河野公子
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation] トラック運転者における眠気のない睡眠呼吸障害の有病率2010

    • Author(s)
      谷川武、斉藤功、櫻井進、村木功、中野博
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 夜間の間欠的低酸素状態と2型糖尿病発症の関連;CIRCS研究2010

    • Author(s)
      村木功、谷川武、山岸良匡、櫻井進、大平哲也、今野弘規、北村明彦、木山昌彦、佐藤眞一、嶋本喬、磯博康
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 夜間の間欠的低酸素状態とメタボリックシンドロームの関連;CIRCS研究2010

    • Author(s)
      村木功、谷川武、櫻井進、山岸良匡、大平哲也、今野弘規、木山昌彦、北村明彦、佐藤眞一、磯博康
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠時無呼吸症候群と各種生活習慣病との関連2010

    • Author(s)
      谷川武
    • Organizer
      第80回日本衛生学会学術集会連携研究会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Screening for sleep disordered breathing among truck drivers in Japan.2009

    • Author(s)
      Sakurai S, Nakano H, Tanigawa T.
    • Organizer
      1st Sleep Summit in Asia-Oceania.
    • Place of Presentation
      Okinawa, Japan.
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Screening for sleep disordered breathing among truck drivers in Japan2009

    • Author(s)
      Sakurai S, Nakano H, Tanigawa T.
    • Organizer
      1st Sleep Summit in Asia-Oceania
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジスト、客観的方法による睡眠呼吸障害スクリーニングの取り組み2009

    • Author(s)
      谷川武
    • Organizer
      日本睡眠学会.大阪国際会議場
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationships of Alcohol Consumption and Arterial Oxygen Desaturation during Sleep among Professional Japanese Truck Drivers.2009

    • Author(s)
      Sakurai S, Cui R, Mori H, Saito I, Yamagishi K, Iso H, Tanigawa T.
    • Organizer
      9th World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea.
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Sleep disordered breathing and biological parameters in Japanese male workers.2009

    • Author(s)
      Mori H, Oikawa T, Sakurai S, Nakano H, Saito I, Katou T, Tanigawa T.
    • Organizer
      9th World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea.
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Non-Sleepy Sleep Apnea (NOSSA) : An Important Public Health Burden.2009

    • Author(s)
      Tanigawa T, Nakano H, Sakurai S.
    • Organizer
      9th World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea.
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Non-Sleepy Sleep Apnea(NOSSA) : An Important Public Health Burden. Invited Speaker2009

    • Author(s)
      Tanigawa T, Nakano H, Sakurai S
    • Organizer
      9^<th> World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relationship of alcohol consumption and arterial oxygen desaturation during sleep atmngprofessional Japanese truck drivers2009

    • Author(s)
      Sakurai S, Cui R, Mori H, Saito I, Yamagishi K, Iso H, Tanigawa T
    • Organizer
      9th World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 基調講演、睡眠時無呼吸症候群と交通事故~取り組みの現状と課題ら~2008

    • Author(s)
      谷川武
    • Organizer
      2008年度第1回国際交通安全学会
    • Place of Presentation
      大手町ファーストスクエア,東京
    • Year and Date
      2008-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 地域住民における睡眠呼吸障害と高血圧発症の関連2008

    • Author(s)
      斉藤功、櫻井進、谷川武、永吉真子、池原賢代、村木功、大平哲也、磯博康、山岸良匡、今野弘規、北村明彦、小西正光
    • Organizer
      第41回睡眠呼吸障害研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Related Report
      2010 Final Research Report
  • [Presentation] High prevalence of moderate to severe sleep disordered breathing without daytime hypersomnolence in Japanese male truck drivers.2008

    • Author(s)
      Tanigawa T, Nakano H, Sakurai S.
    • Organizer
      The 22th Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore, MD
    • Year and Date
      2008-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Screening for sleep-disordered breathing in community and in workplace.2008

    • Author(s)
      Tanigawa T, Sakurai S, Nakano H, Iso H.
    • Organizer
      5th Sleep Respiratory Forum in Otaru.
    • Place of Presentation
      Japan.
    • Related Report
      2010 Final Research Report
  • [Book] 疾患概念-SDBの疫学.(はじめて診る睡眠呼吸障害(SDB)を見逃さないために)2009

    • Author(s)
      谷川武、村木功、櫻井進
    • Publisher
      東京:診断と治療社
    • Related Report
      2010 Final Research Report
  • [Book] 診断総説-問診と簡易検査.(はじめて診る睡眠呼吸障害(SDB)を見逃さないために)2009

    • Author(s)
      櫻井進、淡野桜子、谷川武
    • Publisher
      東京:診断と治療社
    • Related Report
      2010 Final Research Report
  • [Book] SASの疫学.(睡眠時無呼吸症候群改訂第2版)2009

    • Author(s)
      村木功、谷川武
    • Publisher
      東京:克誠堂出版
    • Related Report
      2010 Final Research Report
  • [Book] 睡眠時無呼吸症候群スクリーニング.(睡眠学ハンドブック)2009

    • Author(s)
      谷川武、櫻井進
    • Publisher
      東京:朝倉書店
    • Related Report
      2010 Final Research Report
  • [Book] 睡眠学 (睡眠時無呼吸症候群スクリーニング)2009

    • Author(s)
      谷川武, 櫻井進
    • Publisher
      朝倉書店
    • Related Report
      2008 Annual Research Report
  • [Book] 職域における睡眠時無呼吸症候群(SAS)スクリーニングの重要性.(睡眠障害の基礎知識)2008

    • Author(s)
      谷川武、櫻井進
    • Publisher
      東京:日本労務研究会
    • Related Report
      2010 Final Research Report
  • [Book] 睡眠障害の基礎知識(職域におする睡眠時無呼吸症候群(SAS)スクリーニングの重要性)2008

    • Author(s)
      谷川武, 櫻井進
    • Publisher
      日本労務研究会
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.m.ehime-u.ac.jp/school/publichealth/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.pbhel.med.osaka-u.ac.jp/home.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/community-med/publicmd/public_health_medicine/achievement.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/school/publichealth/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.pbhel.med.osaka-u.ac.jp/home.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/community-med/publicmd/public_health_medicine/achievetnent.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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