A prospective cohort study for sleep-disordered breathing and the progress of carotid atherosclerosis

• Project/Area Number: 20590634
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Ehime University
• Principal Investigator: SAKURAI Susumu Ehime University, 大学院・医学系研究科, 講師 (50375515)
• Co-Investigator(Kenkyū-buntansha): TANIGAWA Takeshi 愛媛大学, 大学院・医学系研究科, 教授 (80227214) ; SAITO Isao 愛媛大学, 大学院・医学系研究科, 准教授 (90253781) ; KITAMURA Akihiko 大阪府立健康科学センター, 健康開発部, 部長 (80450922)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 睡眠呼吸障害 / コホート研究 / パルスオキシメトリ法 / フローセンサ法 / 頚動脈エコー検査 / 動脈硬化 / コホート調査 / 心筋梗塞 / 脳梗塞

Research Abstract

Sleep-disordered breathing (SDB) is characterized by repeated episodes of partial and/or complete airway obstruction during sleep. Recent several clinical studies have indicated that patients with SDB are at increased risk for cardiovascular diseases. But few studies have been described epidemiological study in Japanese. Therefore, we conducted a cohort study to evaluate the progress of cardiovascular atherosclerosis and an effect of the severity of SDB and highly high-sensitive CRP among Japanese.
In conclusion, the undiagnosed or untreated SDB suggest the cause for the progress of cardiovascular atherosclerosis among Japanese.

Research Products

• [Journal Article] 睡眠医療専門機関受診者における睡眠呼吸障害と交通事故との関連 (2010)
  • Author(s): 櫻井進、大平哲也、前田均、津田徹、成井浩司、吉田良子、谷川武
  • Journal Title: 厚生の指標 57 Pages: 6-13
  • NAID: 40017087061
  • Peer Reviewed
• [Journal Article] Cross-cultural comparison of the sleep-disordered breathing prevalence among Americans and Japanese (2010)
  • Author(s): Yamagishi K, Ohira T, Nakano H, Bielinski SJ, Sakurai S, Imano H, Kiyama M, Kitamura A, Sato S, Konishi M, Shahar E, Folsom AR, Iso H, Tanigawa T.
  • Journal Title: Eur Respir J. Jan 28(E Pub)
  • Peer Reviewed
• [Journal Article] Nocturnal Intermittent Hypoxia and Metabolic Syndrome ; the Effect of being Overweight : the CIRCS Study (2010)
  • Author(s): Muraki I, Tanigawa T, Yamagishi K, Sakurai S, Ohira T, Imano H, Kiyama M, Kitamura A, Sato S, Shimamoto T, Konishi M, Iso H.
  • Journal Title: J Atheroscler Thromb. Jan 26(E Pub)
  • NAID: 130004444431
  • Peer Reviewed
• [Journal Article] Nocturnal intermittent hypoxia and the development of type 2 diabetes : the Circulatory Risk in Communities Study(CIRCS) (2010)
  • Author(s): Muraki I, Tanigawa T, Yamagishi K, Sakurai S, Ohira T, Imano H, Kitamura A, Kiyama M, Sato S, Shimamoto T, Konishi M, Iso H; CIRCS Investigators
  • Journal Title: Diabetologia 53 Pages: 481-488
  • Peer Reviewed
• [Journal Article] Relationships of soluble E-selectin and high-sensitivity C-reactive protein with carotid atherosclerosis in Japanese men. (2009)
  • Author(s): Sakurai S, Kitamura A, Cui R, Yamagishi K, Tanigawa T, Iso H.
  • Journal Title: J Atheroscler Thromb. 16(4) Pages: 339-345
  • NAID: 10025766117
  • Peer Reviewed
• [Journal Article] Risk factors for snoring among Japanese men and women : a community-based cross-sectional study (2009)
  • Author(s): Nagayoshi M, Yamagishi K, Tanigawa T, Sakurai S, Kitamura A, Kiyama M, Imano H, Ohira T, Sato S, Sankai T, Iso H; for the CIRCS Investigators
  • Journal Title: Steep Breath. Dec 29(E Pub)
  • Peer Reviewed
• [Journal Article] Associations between weight change since 20 years of age and sleep-disordered breathing among male truck drivers (2009)
  • Author(s): Cui R, Tanigawa T, Nakano H, Sakurai S, Yamagishi K, Ohira T, Iso H.
  • Journal Title: Int J Obes(Lond) 33 Pages: 1396-1401
  • Peer Reviewed
• [Journal Article] Relationships of soluble E-selectin and high-sensitivity C-reactive protein with carotid atherosclerosis in Japanese men (2009)
  • Author(s): Sakurai S, Kitamura A, Cui R, Yamagishi K, Tanigawa T, Iso H.
  • Journal Title: J Atheroscler Thromb 16 Pages: 339-345
  • NAID: 10025766117
  • Peer Reviewed
• [Journal Article] Association of cardiovascular risk factors with carotid atherosclerosis in middle-aged Japanesemen with metabolic syndrome (2008)
  • Author(s): Kirii K, Tanaka S, Yamagishi K, Iso H, Sakurai S, Tanigawa T
  • Journal Title: Ind Health 46 Pages: 607-612
  • Peer Reviewed
• [Presentation] SDB/SASと労働安全衛生対策シンポジウムシンポジスト (2010)
  • Author(s): 谷川武
  • Organizer: 職域におけるSDB/SASスクリーニングの現状と課題.睡眠呼吸障害研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-03
• [Presentation] 地域・職域の健康管理活動から睡眠時無呼吸症候群を検出する意識に関する検討 (2010)
  • Author(s): 淡野桜子、谷川武、得居靖正、岡靖哲、櫻井進、河野公子
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-02
• [Presentation] トラック運転者における眠気のない睡眠呼吸障害の有病率 (2010)
  • Author(s): 谷川武、斉藤功、櫻井進、村木功、中野博
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-02
• [Presentation] 夜間の間欠的低酸素状態と2型糖尿病発症の関連;CIRCS研究 (2010)
  • Author(s): 村木功、谷川武、山岸良匡、櫻井進、大平哲也、今野弘規、北村明彦、木山昌彦、佐藤眞一、嶋本喬、磯博康
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-01
• [Presentation] 夜間の間欠的低酸素状態とメタボリックシンドロームの関連;CIRCS研究 (2010)
  • Author(s): 村木功、谷川武、櫻井進、山岸良匡、大平哲也、今野弘規、木山昌彦、北村明彦、佐藤眞一、磯博康
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-01
• [Presentation] 睡眠時無呼吸症候群と各種生活習慣病との関連 (2010)
  • Author(s): 谷川武
  • Organizer: 第80回日本衛生学会学術集会連携研究会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-09
• [Presentation] Screening for sleep disordered breathing among truck drivers in Japan. (2009)
  • Author(s): Sakurai S, Nakano H, Tanigawa T.
  • Organizer: 1st Sleep Summit in Asia-Oceania.
  • Place of Presentation: Okinawa, Japan.
  • Year and Date: 2009-10-31
• [Presentation] Screening for sleep disordered breathing among truck drivers in Japan (2009)
  • Author(s): Sakurai S, Nakano H, Tanigawa T.
  • Organizer: 1st Sleep Summit in Asia-Oceania
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2009-10-31
• [Presentation] シンポジスト、客観的方法による睡眠呼吸障害スクリーニングの取り組み (2009)
  • Author(s): 谷川武
  • Organizer: 日本睡眠学会.大阪国際会議場
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-25
• [Presentation] Relationships of Alcohol Consumption and Arterial Oxygen Desaturation during Sleep among Professional Japanese Truck Drivers. (2009)
  • Author(s): Sakurai S, Cui R, Mori H, Saito I, Yamagishi K, Iso H, Tanigawa T.
  • Organizer: 9th World Congress on Sleep Apnea
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2009-03-26
• [Presentation] Sleep disordered breathing and biological parameters in Japanese male workers. (2009)
  • Author(s): Mori H, Oikawa T, Sakurai S, Nakano H, Saito I, Katou T, Tanigawa T.
  • Organizer: 9th World Congress on Sleep Apnea
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2009-03-26
• [Presentation] Non-Sleepy Sleep Apnea (NOSSA) : An Important Public Health Burden. (2009)
  • Author(s): Tanigawa T, Nakano H, Sakurai S.
  • Organizer: 9th World Congress on Sleep Apnea
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2009-03-26
• [Presentation] Non-Sleepy Sleep Apnea(NOSSA) : An Important Public Health Burden. Invited Speaker (2009)
  • Author(s): Tanigawa T, Nakano H, Sakurai S
  • Organizer: 9^<th> World Congress on Sleep Apnea
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-03-26
• [Presentation] Relationship of alcohol consumption and arterial oxygen desaturation during sleep atmngprofessional Japanese truck drivers (2009)
  • Author(s): Sakurai S, Cui R, Mori H, Saito I, Yamagishi K, Iso H, Tanigawa T
  • Organizer: 9th World Congress on Sleep Apnea
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-03-26
• [Presentation] 基調講演、睡眠時無呼吸症候群と交通事故～取り組みの現状と課題ら～ (2008)
  • Author(s): 谷川武
  • Organizer: 2008年度第1回国際交通安全学会
  • Place of Presentation: 大手町ファーストスクエア,東京
  • Year and Date: 2008-07-18
• [Presentation] 地域住民における睡眠呼吸障害と高血圧発症の関連 (2008)
  • Author(s): 斉藤功、櫻井進、谷川武、永吉真子、池原賢代、村木功、大平哲也、磯博康、山岸良匡、今野弘規、北村明彦、小西正光
  • Organizer: 第41回睡眠呼吸障害研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-12
• [Presentation] High prevalence of moderate to severe sleep disordered breathing without daytime hypersomnolence in Japanese male truck drivers. (2008)
  • Author(s): Tanigawa T, Nakano H, Sakurai S.
  • Organizer: The 22th Annual Meeting of the Associated Professional Sleep Societies
  • Place of Presentation: Baltimore, MD
  • Year and Date: 2008-06-11
• [Presentation] Screening for sleep-disordered breathing in community and in workplace. (2008)
  • Author(s): Tanigawa T, Sakurai S, Nakano H, Iso H.
  • Organizer: 5th Sleep Respiratory Forum in Otaru.
  • Place of Presentation: Japan.
• [Book] 疾患概念-SDBの疫学.(はじめて診る睡眠呼吸障害(SDB)を見逃さないために) (2009)
  • Author(s): 谷川武、村木功、櫻井進
  • Publisher: 東京:診断と治療社
• [Book] 診断総説-問診と簡易検査.(はじめて診る睡眠呼吸障害(SDB)を見逃さないために) (2009)
  • Author(s): 櫻井進、淡野桜子、谷川武
  • Publisher: 東京:診断と治療社
• [Book] SASの疫学.(睡眠時無呼吸症候群改訂第2版) (2009)
  • Author(s): 村木功、谷川武
  • Publisher: 東京:克誠堂出版
• [Book] 睡眠時無呼吸症候群スクリーニング.(睡眠学ハンドブック) (2009)
  • Author(s): 谷川武、櫻井進
  • Publisher: 東京:朝倉書店
• [Book] 睡眠学 (睡眠時無呼吸症候群スクリーニング) (2009)
  • Author(s): 谷川武, 櫻井進
  • Publisher: 朝倉書店
• [Book] 職域における睡眠時無呼吸症候群(SAS)スクリーニングの重要性.(睡眠障害の基礎知識) (2008)
  • Author(s): 谷川武、櫻井進
  • Publisher: 東京:日本労務研究会
• [Book] 睡眠障害の基礎知識(職域におする睡眠時無呼吸症候群(SAS)スクリーニングの重要性) (2008)
  • Author(s): 谷川武, 櫻井進
  • Publisher: 日本労務研究会
• [Remarks] ホームページ等
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