Mechanism for vascular dysfunction caused by visceral fat-derived reactive oxygen species

• Project/Area Number: 20590651
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: University of the Ryukyus
• Principal Investigator: SHIMABUKURO Michio University of the Ryukyus, 医学部附属病院, 講師 (60271144)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 内臓肥満症 / 血管内皮機能 / 心筋梗塞 / 活性酸素種 / メタボリックシンドローム / 内蔵肥満症

Research Abstract

In patients with the metabolic syndrome, vascular dysfunction cause cardiovascular events. We previously reported that visceral fat-derived reactive oxygen species (ROS) underlie onset of the metabolic syndrome. In this study, we found that firs, human umbilical vein endothelium produce ROS by addition of palmitic acid, a saturated free fatty acid ; second, palmitic acid induces complex of anti- and pro-ROS proteins in HUVEC ; third, obese animal did not show any vascular dysfunction if it fed normal fat chow. Collectively, saturated fat can directly produce ROS and related proteins in endothelium, and regulate endothelia function.

Research Products

• [Journal Article] Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients of type 2 diabetes mellitus. (2011)
  • Author(s): Shimabukuro M, Higa M, Tanaka H, Shimabukuro T, Yamakawa K, Masuzaki H
  • Journal Title: Diabetic Med 28 Pages: 856-64
  • Peer Reviewed
• [Journal Article] Impaired glucose tolerance, but not impaired fasting glucose, underlies left ventricular diastolic dysfunction. (2011)
  • Author(s): Shimabukuro M, Higa N, Asahi T, PhD, Yamakawa K, Oshiro Y, Higa M, Masuzaki H.
  • Journal Title: Diabetes Care 34 Pages: 686-690
  • Peer Reviewed
• [Journal Article] Impaired glucose tolerance, but not impaired fasting glucose, underlies left ventricular diastolic dysfunction. (2011)
  • Author(s): Shimabukuro M, et al.
  • Journal Title: Diabetes Care Volume: 34 Pages: 686-690
  • Peer Reviewed
• [Journal Article] Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients of type 2 diabetes mellitus. (2011)
  • Author(s): Shimabukuro M, et al.
  • Journal Title: Diabetic Medicine Volume: (in press)
  • Peer Reviewed
• [Journal Article] Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate : subanalysis from the JPAD (2011)
  • Author(s): Saito Y, et al.
  • Journal Title: Diabetes Care Volume: 34 Pages: 280-285
  • Peer Reviewed
• [Journal Article] Effective Prediction of Response to Cardiac Resynchronization Therapy Using a Novel Program of Gated Myocardial Perfusion (2011)
  • Author(s): Nakamura K, et al.
  • Journal Title: Europace Volume: (in press)
  • Peer Reviewed
• [Journal Article] Human Catalase Gene is Regulated by Peroxisome Proliferator Activated Receptor-gamma through a Response Element Distinct from That of Mouse. (2010)
  • Author(s): Okuno Y, Matsuda M, Miyata Y, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I.
  • Journal Title: Endocr J. 57 Pages: 303-309
  • NAID: 10029584294
  • Peer Reviewed
• [Journal Article] Impact of drug alteration to maintain rhythm control in paroxysmal atrial fibrillation. -Subanalysis from J-RHYTHM (2010)
  • Author(s): Endo A, et al.
  • Journal Title: Circulation Journal Volume: 74 Pages: 870-875
  • Peer Reviewed
• [Journal Article] Human catalase gene is regulated by peroxisome proliferator activated receptor-gamma through a response element distinct (2010)
  • Author(s): Okuno Y, et al.
  • Journal Title: Endocrine Journal Volume: 57 Pages: 303-309
  • Peer Reviewed
• [Journal Article] Human Catalase Gene is Regulated by Peroxisome Proliferator Activated Receptor-gamma through a Response Element Distinct from That of Mouse (2010)
  • Author(s): Okuno Y
  • Journal Title: Endocr J. (in press)
  • Peer Reviewed
• [Journal Article] Standard-dose statin therapy provides incremental clinical benefits in normocholesterolemic diabetic patients (2010)
  • Author(s): Kojima S
  • Journal Title: Circ J. 74 Pages: 779-785
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance (2010)
  • Author(s): Tabata M
  • Journal Title: Cell Metab. 10 Pages: 178-188
  • Peer Reviewed
• [Journal Article] Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes : A randomized controlled trial. JAMA.2008 : 300 : 2134-2141 (2010)
  • Author(s): Ogawa H
  • Journal Title: JAMA. 300 Pages: 2134-2141
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. (2009)
  • Author(s): Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y.
  • Journal Title: Cell Metab. 10 Pages: 178-88
  • Peer Reviewed
• [Journal Article] Cardiac adiposity and global cardiometabolic risk. (2009)
  • Author(s): Shimabukuro M.
  • Journal Title: Circ J. 73 Pages: 27-34
  • Peer Reviewed
• [Journal Article] Adipose expression of catalase is regulated via a novel remote PPAR γ-responsive region. (2008)
  • Author(s): Okuno Y 、Matsuda M 、Kobayashi H 、Nakamura H 、Suzuki E 、Morita K 、Fukuhara A、Komuro R、Shimabukuro M、 Shimomura I.
  • Journal Title: Biochem Biophys Res Commun 366 Pages: 698-704
  • Peer Reviewed
• [Journal Article] High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes : The Kyushu Prevention Study for Atherosclerosis. (2008)
  • Author(s): Maeda Y, Inoguchi T, Tsubouchi H, Sawada F, Sasaki S, Fujii M, Saito R, Yanase T, Shimabukuro M, Nawata H, Takayanagi R.
  • Journal Title: Diabetes Res Clin Pract 82 Pages: 378-382
  • Peer Reviewed
• [Journal Article] Adipose expression of catalase is regulated via a novel remote PPAR γ-responsive region. (2008)
  • Author(s): Okuno Y, Matsuda M, Kobayashi H, Nakamura H, Suzuki E, Morita K, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I.
  • Journal Title: Biochem Biophys Res Commun 366 Pages: 698-704
  • Peer Reviewed
• [Journal Article] High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes: The Kyushu Prevention study for Atherosclerosis. (2008)
  • Author(s): Maeda Y, Inoguchi T, Tsubouchi H, Sawada F, Sasaki S, Fujii M, Saito R, Yanase T, Shimabukuro M, Nawata H, Takayanagi R.
  • Journal Title: Diabetes Res Clin Pract 82 Pages: 378-382
  • Peer Reviewed
• [Presentation] Ectopic fat deposition (EFD), metabolic syndrome, and type 2 diabetes. (2010)
  • Author(s): Shimabukuro M, Masuzaki H.
  • Organizer: ICE 2010 Satellite program, Obesity and Metabolic Syndrome.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-30
• [Presentation] Ectopic fat deposition and lipotoxic disorders. (2010)
  • Author(s): Shimabukuro M, Masuzaki H.
  • Organizer: JES-Sponsored Symposia, 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-28
• [Presentation] Effects of miglitol on fat distribution and insulin sensitivity in subjects with metabolic syndrome. (2010)
  • Author(s): Shimabukuro M, Higa M, Tanaka H, Uezu Y. Masuzaki H.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Effects of brown and white rice diet on visceral adiposity and endothelial function : The BRAVO study. (2010)
  • Author(s): Hasegawa J, Higa M, Tanaka H, Shimabukuro M, Masuzaki H.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Visceral adiposity strongly predicts delayed hyperinsulinemia in obese and non-obese subjects. (2010)
  • Author(s): Shimabukuro M, Higa M, Masuzaki H.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Effects of miglitol on fat distribution and insulin sensitivity in subjects with metabolic syndrome., Kyoto, Japan (2010)
  • Author(s): Shimabukuro M
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] Effects of brown and white rice diet on visceral adiposity and endothelial function : The BRAVO study (2010)
  • Author(s): Hasegawa J
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] Visceral adiposity strongly predicts delayed hyperinsulinemia in obese and non-obese subjects (2010)
  • Author(s): Shimabukuro M
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] Ectopic fat deposition and lipotoxic disorders (2010)
  • Author(s): Shimabukuro M
  • Organizer: JES-Sponsored Symposia, 14th International Congress of Endocrinology
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] Ectopic fat deposition(EFD), metabolic syndrome, and type 2 diabetes (2010)
  • Author(s): Shimabukuro M
  • Organizer: ICE 2010 Satellite program, Obesity and Metabolic Syndrome
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] Visceral adiposity causes delayed hyperinsulinemia even in non-obese subjects. (2008)
  • Author(s): Higa M, Shimabukuro M, Shiohira Y.
  • Organizer: World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)
  • Place of Presentation: Catalonia Palace of Congresses, Barcelona, Spain
  • Year and Date: 2008-11-01
• [Presentation] Effects of abdominal obesity and insulin resistance on blood pressure and cardiovascular events : A prospective study in 6975 community-based subjects. (2008)
  • Author(s): Shimabukuro M, Higa M, Tanaka H, Shiohira Y, Miyahira M.
  • Organizer: World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)
  • Place of Presentation: Catalonia Palace of Congresses, Barcelona, Spain
  • Year and Date: 2008-11-01
• [Presentation] Effects of a single ingestion of brown and white rice on metabolic parameters and endothelial function. (2008)
  • Author(s): Higa M, Tanaka H, Shimabukuro M.
  • Organizer: 2nd International Symposium on Rice and Disease Prevention
  • Place of Presentation: Wakayama Prefectural Culture Hall, Wakayama, Japan
  • Year and Date: 2008-10-26
• [Book] 異所性脂肪《メタボリックシンドロームの新常識》 (2010)
  • Author(s): 島袋充生、益崎裕章
  • Publisher: 日本医事新報
• [Book] チーム医療レベルアップ糖尿病セミナー(第3巻)ケアネットDVD (2009)
  • Author(s): 田中逸、赤井裕輝、島袋充生、穴澤園子
• [Book] 糖尿病学の進歩 第42集 (2008)
  • Author(s): 島袋充生
  • Total Pages: 289
  • Publisher: 診断と治療社