Preventive effect of histidine and proline on obesity and anorexia through the control of appetite.

• Project/Area Number: 20590666
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Bunkyo University Women's College
• Principal Investigator: NAKAJIMA Shigeru Bunkyo University Women's College, 健康栄養学部, 教授 (90149782)
• Co-Investigator(Kenkyū-buntansha): INOUE Setuko 文教大学, 健康栄養学部, 教授 (60095362) ; KASAOKA Seiichi 文教大学, 健康栄養学部, 准教授 (00331455) ; WATANABE Miki 文教大学, 健康栄養学部, 助教 (20331457)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 肥満 / 拒食 / ヒスチジン / プロリン

Research Abstract

The aim of this study is to investigate the influence of proline for the preventive effect of histidine on obesity. The preventive effect of histidine on obesity seemed to decrease by proline. Because, the meal consist of high histidine/proline ratio seemed to be useful to prevent and dissolve obesity. In the case of aneroxia, body protein change to amino acids to make energy. From this result, histidine in blood seemed to increase and hitamine neuron is activated extraordinary. Because, the meal consist of low histidine/protein ratio seemed to increase the appetite.

Research Products

• [Journal Article] カッオ節製造工程で得られたヒスチジン高含有熱水抽出物経口摂取による血圧降下の可能性 (2011)
  • Author(s): 中島滋、田中香、後藤浄子、浅見悦子、保苅義則、松本透、土屋隆英
  • Journal Title: 日本未病システム学会誌 Volume: 17(印刷中)
  • Peer Reviewed
• [Journal Article] Soichiro Nakamura : Comparisons of Korean and Japanese College Students' Eating Habits and Food Preferences (2010)
  • Author(s): Kyoung Ae Lee, Bo-Young Jeong, Soo-Kyung Moon, In-Soo Kim, Shigeru Nakajima
  • Journal Title: Journal of Korean Society of Food Science and Nutrition 39 Pages: 1619-1626
  • Peer Reviewed
• [Journal Article] 血中ヒスチジン量と動脈硬化危険因子との相関関係 (2010)
  • Author(s): 雨宮有子、中島滋、加部勇、池田啓一、信太直己、山倉文幸、河合祥雄、形本静夫、岩井秀明
  • Journal Title: 日本未病システム学会誌 16 Pages: 17-27
  • NAID: 40017252729
  • Peer Reviewed
• [Journal Article] Suppressed fat accumulation in rats fed a histidine-enriched diet (2010)
  • Author(s): Michiko Endo, Seiichi Kasaoka, Miki Takizawa, Kiyoko Goto, Shigeru Nakajima, S-K Moon, I-S Kim, B-Y Jeong, Soichiro Nakamura
  • Journal Title: Journal of Food Science and Nutrition 15 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Suppressed fat accumulation in rats fed a histidine-enriched diet (2010)
  • Author(s): Michiko Endo, Seiichi Kasaoka, Miki Takizawa, Kiyoko Gotoh, Shigeru Nakajima, S-K Moon, I-S Kim, B-Y Jeong, Soichiro Nakamura
  • Journal Title: Journal of Food Science and Nutrition Volume: 15 Pages: 1-6
  • Peer Reviewed
• [Journal Article] 血中ヒスチジン量と動脈硬化危険因子との相関関係 (2010)
  • Author(s): 雨宮有子、中島滋、加部勇、池田啓一、信太直己、山倉文幸、河合祥雄、形本静夫、岩井秀明
  • Journal Title: 日本未病システム学会誌 Volume: 16 Pages: 17-27
  • NAID: 40017252729
  • Peer Reviewed
• [Journal Article] Comparisons of Korean and Japanese College Students' Eating Habits and Food Preferences (2010)
  • Author(s): Kyoung Ae Lee, Bo-Young Jeong, Soo-Kyung Moon, In-Soo Kim, Shigeru Nakajima, Soichiro Nakamura
  • Journal Title: Journal of Korean Society of Food Science and Nutrition Volume: 39 Pages: 1619-1626
  • Peer Reviewed
• [Journal Article] Suppressed fat accumulation in rats fed with histidine-enriched diet (2010)
  • Author(s): Endo M, Kasaoka S, Takizawa M, Goto K, Nakajima S, Moon S-K, Kim, I-S, Jeong B-Y, Nakamura S
  • Journal Title: Journal of Food Science and Nutrition 15(In press)
  • Peer Reviewed
• [Journal Article] 血中ヒスチジン濃度比とメタボリックシンドローム診断基準値との関係 (2010)
  • Author(s): 中島滋、加瀬澤信彦
  • Journal Title: 日本未病システム学会誌 16(印刷中)
  • Peer Reviewed
• [Journal Article] 食生活と肥満防止との関連を調べる日韓共同研究 (2010)
  • Author(s): 中島滋
  • Journal Title: 湘南フォーラム 16(印刷中)
• [Journal Article] 血中ヒスチジン濃度比とメタボリックシンドローム診断基準との関係 (2009)
  • Author(s): 中島滋、加瀬澤信彦
  • Journal Title: 日本未病システム学会誌 15 Pages: 253-241
  • Peer Reviewed
• [Journal Article] 鰹節抽出物摂取がラット体脂肪および筋肉量に及ぼす影響 (2009)
  • Author(s): 遠藤美智子、滝沢未来、田中香、時高正明、笠岡誠一、中村宗一郎、中島滋
  • Journal Title: 肥満研究 15 Pages: 202-207
  • NAID: 10026150152
  • Peer Reviewed
• [Journal Article] Negative correlations between free histidine content in plasma and BMI or area of visceral fat (2009)
  • Author(s): Yuko Amamiya, Shigeru Nakajima, Keiichi Ikeda, Naoki Shida, Fumiyuki Yamakura, Sachio Kawai, Yuji Nakazato, Shizuo Katamoto, Isamu Kabe, Takahide Tsuchiya, Hideaki Iwa
  • Journal Title: Journal of Physical Fitness, Nutrition and Immunology 18 Pages: 87-91
  • Peer Reviewed
• [Journal Article] Negative correlations between free histidine cintent in plasma and BMI or area if visceral fat (2009)
  • Author(s): Amamiya Y, Nakajima S, Ikeda K, Shida N, Yamakura F, Kawai S, Nakazato Y, Katamoto S, K abe I, Tsuchiya T, Iwai H
  • Journal Title: Journal of Physical Fitness, Nutrition and Immunology 18 Pages: 87-91
  • Peer Reviewed
• [Journal Article] Negative correlations between free histidine content in plasma and BMI or area of visceral fat (2009)
  • Author(s): Amamiya Y, Nakajima S, I keda K, Shida N, Yamakura F, Kawai S, Nakazato Y, Katamoto S. Kabe I, Tsuchiya T, Iwai H
  • Journal Title: Journal of Physical Fitness, Nutrition and Immunology 17(印刷中)
  • Peer Reviewed
• [Journal Article] Suppressive effect of dietary histidine-rich protein on food intake under protein-rich condition especially in female (2008)
  • Author(s): Shigeru Nakajima, Kaoru Tanaka, Setsuko Inoue, Takahide Tsuchiya, Hideaki Iwai, Yuko Amamiya, Yutaka Inaba
  • Journal Title: Journal of Physical Fitness, Nutrition and Immunology 17 Pages: 214-223
  • Peer Reviewed
• [Journal Article] 鰹節抽出物の短期投与によるラットの摂食量および脂肪蓄積量の検討 (2008)
  • Author(s): 笠岡誠一、後藤浄子、時高正明、滝沢未来、田中香、小川眞紀子、中島滋
  • Journal Title: 栄養学雑誌 66 Pages: 127-132
  • NAID: 10021177995
  • Peer Reviewed
• [Journal Article] 鰹節抽出物の短期投与によるラットの摂食量および脂肪蓄積量の検討 (2008)
  • Author(s): 笠岡誠一, 後藤浄子, 時高正明, 滝沢未来, 田中香, 小川眞紀子, 中島滋
  • Journal Title: 栄養学雑誌 66 Pages: 127-132
  • NAID: 10021177995
  • Peer Reviewed
• [Journal Article] Suppressive effect of dietary histidine-rich protein on food intake under protein-rich condition especially in female (2008)
  • Author(s): Nakajima S, Tanaka K, Inoue S, Tsuchiya T, Iwai H, Amamiya Y, Inaba Y
  • Journal Title: Journal of Physical Fitness, Nutrition, Immunology 17 Pages: 214-223
  • Peer Reviewed
• [Journal Article] カツオ節製造工程で得られたヒスチジン高含有熱水抽出物経口摂取による血圧降下の可能性
  • Author(s): 中島滋、田中香、後藤浄子、浅見悦子、保苅義則、松本透、土屋隆英
  • Journal Title: 日本未病システム学会誌 印刷中
  • Peer Reviewed
• [Presentation] ヒスチジンの抗肥満作用に対する大豆食品摂取の影響 (2010)
  • Author(s): 中島滋、浅見悦子、土屋隆英、福生吉裕
  • Organizer: 第16回日本未病システム学会学術総会(ワークショップ)
  • Place of Presentation: 那覇市、沖縄県
  • Year and Date: 2010-11-14
• [Presentation] ヒスチジンの抗肥満作用に対する大豆食品摂取の影響 (2010)
  • Author(s): 中島滋、浅見悦子、土屋隆英、福生吉裕
  • Organizer: 第16回日本未病システム学会学術総会
  • Place of Presentation: 那覇市、沖縄県
  • Year and Date: 2010-11-14
• [Presentation] Dietary Histidine Prevent Obesity Due to Preventing Overeating (2010)
  • Author(s): Seiichi Kasaoka, Kiyoko Goto, Miki Takizawa, Kaoru Tanaka, Shigeru Nakajima
  • Organizer: 6^<th> International Congress of Pathophysiology &14^<th> International SHR Symposium (Montreal CANADA)
  • Place of Presentation: モントリオール, カナダ
  • Year and Date: 2010-09-23
• [Presentation] Dietary Histidine Prevent Obesity Due to Preventing Overeating (2010)
  • Author(s): Seiichi Kasaoka, Kiyoko Goto, Miki Takizawa, Kaoru Tanaka, Shigeru Nakajima
  • Organizer: 46^<th> International Congress of Pathophysiology & 14^<th> International SHR Symposium (Montreal CANADA)
  • Place of Presentation: モントリオール,カナダ
  • Year and Date: 2010-09-23
• [Presentation] 魚と健康 (2010)
  • Author(s): 中島滋
  • Organizer: 日本未病システム学会栄養部会研修会
  • Place of Presentation: 文京区、東京都
  • Year and Date: 2010-06-23
• [Presentation] ヒスチジン摂取ラット脳のDEDC+Cu投与における過酸化脂質濃度の変化について (2010)
  • Author(s): 井上節子、笠岡誠一、中島滋
  • Organizer: 第64回日本栄養・食糧学会総会
  • Place of Presentation: 徳島市、徳島県
  • Year and Date: 2010-05-23
• [Presentation] ヒスチジン摂取による血中カルノシンおよび3-メチルヒスチジン濃度の増加 (2010)
  • Author(s): 後藤浄子、遠藤美智子、田中香、滝沢未来、笠岡誠一、中島滋
  • Organizer: 第64回日本栄養・食糧学会総会
  • Place of Presentation: 徳島市、徳島県
  • Year and Date: 2010-05-23
• [Presentation] 肥満と血中アミノ酸量との関係 (2009)
  • Author(s): 中島滋、田中香、雨宮有子、岩井秀明、加瀬澤信彦
  • Organizer: 21世紀の人類と健康フォーラム・長野
  • Place of Presentation: 信州大学・長野県
  • Year and Date: 2009-09-04
• [Presentation] ヒスチジン摂取ラットの血清、脳におけるDEDCとCu投与による過酸化脂質濃度の変化 (2009)
  • Author(s): 井上節子、中島滋
  • Organizer: 第56回日本栄養改善学会学術総会
  • Place of Presentation: 札幌市、北海道
  • Year and Date: 2009-09-03
• [Presentation] 肥満とアミノ酸-血中ヒスチジン濃度比と肥満メタボリックシンドロームとの関連- (2009)
  • Author(s): 中島滋、加瀬澤信彦
  • Organizer: 第2回日本未病システム学会栄養部会・臨床検査部会合同セミナー
  • Place of Presentation: 東京都
  • Year and Date: 2009-07-12
• [Presentation] ヒスチジン摂取による食行動には性差が認められる (2009)
  • Author(s): 後藤浄子、笠岡誠一、遠藤美智子、田中香、中島滋
  • Organizer: 第63回日本栄養・食糧学会総会
  • Place of Presentation: 長崎市、長崎県
  • Year and Date: 2009-05-22
• [Presentation] ヒスチジン摂取がラットの血糖値に及ぼす影響 (2009)
  • Author(s): 遠藤美智子、田中香、滝沢未来、笠岡誠一、中島滋
  • Organizer: 第63回日本栄養・食糧学会総会
  • Place of Presentation: 長崎市、長崎県
  • Year and Date: 2009-05-21
• [Presentation] (2009)
  • Author(s): Shigeru Nakajima, Hideaki Iwai, Soichiro Nakamura, Seiichi Kasaoka, Keiichi Ikeda, Yuko Amamiya, Fumiyuki Yamakura, Sachio Kawai, Shizuo Katamoto
  • Organizer: 237th American Chemical Society National Meeting & Exposition
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2009-03-22
• [Presentation] ヒスチジン摂取によるラットの血中グルコース濃度低下作用 (2008)
  • Author(s): 遠藤美智子, 田中香, 滝沢未来, 笠岡誠一, 中島滋
  • Organizer: 第55回日本栄養改善学会学術総会
  • Place of Presentation: 鎌倉女子大学
  • Year and Date: 2008-09-06
• [Book] Seafood Quality, Safety, and Health(「Suppressive effects of marine foods intake on obesity and life style related diseases」) (2010)
  • Author(s): Shigeru Nakajima
  • Publisher: The blackwell Publisher (United Kingdom)
• [Book] 「Suppressive effects of marine foods intake on obesity and life style related diseases」 in 「Seafood Quality, Safety, and Health」 (2010)
  • Author(s): Shigeru Nakajima
  • Publisher: The blackwell Publisher (United Kingdom)