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Preventive effect of histidine and proline on obesity and anorexia through the control of appetite.

Research Project

Project/Area Number 20590666
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionBunkyo University Women's College

Principal Investigator

NAKAJIMA Shigeru  Bunkyo University Women's College, 健康栄養学部, 教授 (90149782)

Co-Investigator(Kenkyū-buntansha) INOUE Setuko  文教大学, 健康栄養学部, 教授 (60095362)
KASAOKA Seiichi  文教大学, 健康栄養学部, 准教授 (00331455)
WATANABE Miki  文教大学, 健康栄養学部, 助教 (20331457)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords肥満 / 拒食 / ヒスチジン / プロリン
Research Abstract

The aim of this study is to investigate the influence of proline for the preventive effect of histidine on obesity. The preventive effect of histidine on obesity seemed to decrease by proline. Because, the meal consist of high histidine/proline ratio seemed to be useful to prevent and dissolve obesity. In the case of aneroxia, body protein change to amino acids to make energy. From this result, histidine in blood seemed to increase and hitamine neuron is activated extraordinary. Because, the meal consist of low histidine/protein ratio seemed to increase the appetite.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009 2008 Other

All Journal Article (20 results) (of which Peer Reviewed: 19 results) Presentation (14 results) Book (2 results)

  • [Journal Article] カッオ節製造工程で得られたヒスチジン高含有熱水抽出物経口摂取による血圧降下の可能性2011

    • Author(s)
      中島滋、田中香、後藤浄子、浅見悦子、保苅義則、松本透、土屋隆英
    • Journal Title

      日本未病システム学会誌

      Volume: 17(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soichiro Nakamura : Comparisons of Korean and Japanese College Students' Eating Habits and Food Preferences2010

    • Author(s)
      Kyoung Ae Lee, Bo-Young Jeong, Soo-Kyung Moon, In-Soo Kim, Shigeru Nakajima
    • Journal Title

      Journal of Korean Society of Food Science and Nutrition 39

      Pages: 1619-1626

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血中ヒスチジン量と動脈硬化危険因子との相関関係2010

    • Author(s)
      雨宮有子、中島滋、加部勇、池田啓一、信太直己、山倉文幸、河合祥雄、形本静夫、岩井秀明
    • Journal Title

      日本未病システム学会誌 16

      Pages: 17-27

    • NAID

      40017252729

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppressed fat accumulation in rats fed a histidine-enriched diet2010

    • Author(s)
      Michiko Endo, Seiichi Kasaoka, Miki Takizawa, Kiyoko Goto, Shigeru Nakajima, S-K Moon, I-S Kim, B-Y Jeong, Soichiro Nakamura
    • Journal Title

      Journal of Food Science and Nutrition 15

      Pages: 1-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppressed fat accumulation in rats fed a histidine-enriched diet2010

    • Author(s)
      Michiko Endo, Seiichi Kasaoka, Miki Takizawa, Kiyoko Gotoh, Shigeru Nakajima, S-K Moon, I-S Kim, B-Y Jeong, Soichiro Nakamura
    • Journal Title

      Journal of Food Science and Nutrition

      Volume: 15 Pages: 1-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血中ヒスチジン量と動脈硬化危険因子との相関関係2010

    • Author(s)
      雨宮有子、中島滋、加部勇、池田啓一、信太直己、山倉文幸、河合祥雄、形本静夫、岩井秀明
    • Journal Title

      日本未病システム学会誌

      Volume: 16 Pages: 17-27

    • NAID

      40017252729

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparisons of Korean and Japanese College Students' Eating Habits and Food Preferences2010

    • Author(s)
      Kyoung Ae Lee, Bo-Young Jeong, Soo-Kyung Moon, In-Soo Kim, Shigeru Nakajima, Soichiro Nakamura
    • Journal Title

      Journal of Korean Society of Food Science and Nutrition

      Volume: 39 Pages: 1619-1626

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressed fat accumulation in rats fed with histidine-enriched diet2010

    • Author(s)
      Endo M, Kasaoka S, Takizawa M, Goto K, Nakajima S, Moon S-K, Kim, I-S, Jeong B-Y, Nakamura S
    • Journal Title

      Journal of Food Science and Nutrition 15(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血中ヒスチジン濃度比とメタボリックシンドローム診断基準値との関係2010

    • Author(s)
      中島滋、加瀬澤信彦
    • Journal Title

      日本未病システム学会誌 16(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食生活と肥満防止との関連を調べる日韓共同研究2010

    • Author(s)
      中島滋
    • Journal Title

      湘南フォーラム 16(印刷中)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 血中ヒスチジン濃度比とメタボリックシンドローム診断基準との関係2009

    • Author(s)
      中島滋、加瀬澤信彦
    • Journal Title

      日本未病システム学会誌 15

      Pages: 253-241

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 鰹節抽出物摂取がラット体脂肪および筋肉量に及ぼす影響2009

    • Author(s)
      遠藤美智子、滝沢未来、田中香、時高正明、笠岡誠一、中村宗一郎、中島滋
    • Journal Title

      肥満研究 15

      Pages: 202-207

    • NAID

      10026150152

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative correlations between free histidine content in plasma and BMI or area of visceral fat2009

    • Author(s)
      Yuko Amamiya, Shigeru Nakajima, Keiichi Ikeda, Naoki Shida, Fumiyuki Yamakura, Sachio Kawai, Yuji Nakazato, Shizuo Katamoto, Isamu Kabe, Takahide Tsuchiya, Hideaki Iwa
    • Journal Title

      Journal of Physical Fitness, Nutrition and Immunology 18

      Pages: 87-91

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negative correlations between free histidine cintent in plasma and BMI or area if visceral fat2009

    • Author(s)
      Amamiya Y, Nakajima S, Ikeda K, Shida N, Yamakura F, Kawai S, Nakazato Y, Katamoto S, K abe I, Tsuchiya T, Iwai H
    • Journal Title

      Journal of Physical Fitness, Nutrition and Immunology 18

      Pages: 87-91

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative correlations between free histidine content in plasma and BMI or area of visceral fat2009

    • Author(s)
      Amamiya Y, Nakajima S, I keda K, Shida N, Yamakura F, Kawai S, Nakazato Y, Katamoto S. Kabe I, Tsuchiya T, Iwai H
    • Journal Title

      Journal of Physical Fitness, Nutrition and Immunology 17(印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effect of dietary histidine-rich protein on food intake under protein-rich condition especially in female2008

    • Author(s)
      Shigeru Nakajima, Kaoru Tanaka, Setsuko Inoue, Takahide Tsuchiya, Hideaki Iwai, Yuko Amamiya, Yutaka Inaba
    • Journal Title

      Journal of Physical Fitness, Nutrition and Immunology 17

      Pages: 214-223

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 鰹節抽出物の短期投与によるラットの摂食量および脂肪蓄積量の検討2008

    • Author(s)
      笠岡誠一、後藤浄子、時高正明、滝沢未来、田中香、小川眞紀子、中島滋
    • Journal Title

      栄養学雑誌 66

      Pages: 127-132

    • NAID

      10021177995

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 鰹節抽出物の短期投与によるラットの摂食量および脂肪蓄積量の検討2008

    • Author(s)
      笠岡誠一, 後藤浄子, 時高正明, 滝沢未来, 田中香, 小川眞紀子, 中島滋
    • Journal Title

      栄養学雑誌 66

      Pages: 127-132

    • NAID

      10021177995

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effect of dietary histidine-rich protein on food intake under protein-rich condition especially in female2008

    • Author(s)
      Nakajima S, Tanaka K, Inoue S, Tsuchiya T, Iwai H, Amamiya Y, Inaba Y
    • Journal Title

      Journal of Physical Fitness, Nutrition, Immunology 17

      Pages: 214-223

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カツオ節製造工程で得られたヒスチジン高含有熱水抽出物経口摂取による血圧降下の可能性

    • Author(s)
      中島滋、田中香、後藤浄子、浅見悦子、保苅義則、松本透、土屋隆英
    • Journal Title

      日本未病システム学会誌 印刷中

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] ヒスチジンの抗肥満作用に対する大豆食品摂取の影響2010

    • Author(s)
      中島滋、浅見悦子、土屋隆英、福生吉裕
    • Organizer
      第16回日本未病システム学会学術総会(ワークショップ)
    • Place of Presentation
      那覇市、沖縄県
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒスチジンの抗肥満作用に対する大豆食品摂取の影響2010

    • Author(s)
      中島滋、浅見悦子、土屋隆英、福生吉裕
    • Organizer
      第16回日本未病システム学会学術総会
    • Place of Presentation
      那覇市、沖縄県
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dietary Histidine Prevent Obesity Due to Preventing Overeating2010

    • Author(s)
      Seiichi Kasaoka, Kiyoko Goto, Miki Takizawa, Kaoru Tanaka, Shigeru Nakajima
    • Organizer
      6^<th> International Congress of Pathophysiology &14^<th> International SHR Symposium (Montreal CANADA)
    • Place of Presentation
      モントリオール, カナダ
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Dietary Histidine Prevent Obesity Due to Preventing Overeating2010

    • Author(s)
      Seiichi Kasaoka, Kiyoko Goto, Miki Takizawa, Kaoru Tanaka, Shigeru Nakajima
    • Organizer
      46^<th> International Congress of Pathophysiology & 14^<th> International SHR Symposium (Montreal CANADA)
    • Place of Presentation
      モントリオール,カナダ
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 魚と健康2010

    • Author(s)
      中島滋
    • Organizer
      日本未病システム学会栄養部会研修会
    • Place of Presentation
      文京区、東京都
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒスチジン摂取ラット脳のDEDC+Cu投与における過酸化脂質濃度の変化について2010

    • Author(s)
      井上節子、笠岡誠一、中島滋
    • Organizer
      第64回日本栄養・食糧学会総会
    • Place of Presentation
      徳島市、徳島県
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒスチジン摂取による血中カルノシンおよび3-メチルヒスチジン濃度の増加2010

    • Author(s)
      後藤浄子、遠藤美智子、田中香、滝沢未来、笠岡誠一、中島滋
    • Organizer
      第64回日本栄養・食糧学会総会
    • Place of Presentation
      徳島市、徳島県
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肥満と血中アミノ酸量との関係2009

    • Author(s)
      中島滋、田中香、雨宮有子、岩井秀明、加瀬澤信彦
    • Organizer
      21世紀の人類と健康フォーラム・長野
    • Place of Presentation
      信州大学・長野県
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒスチジン摂取ラットの血清、脳におけるDEDCとCu投与による過酸化脂質濃度の変化2009

    • Author(s)
      井上節子、中島滋
    • Organizer
      第56回日本栄養改善学会学術総会
    • Place of Presentation
      札幌市、北海道
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肥満とアミノ酸-血中ヒスチジン濃度比と肥満メタボリックシンドロームとの関連-2009

    • Author(s)
      中島滋、加瀬澤信彦
    • Organizer
      第2回日本未病システム学会栄養部会・臨床検査部会合同セミナー
    • Place of Presentation
      東京都
    • Year and Date
      2009-07-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒスチジン摂取による食行動には性差が認められる2009

    • Author(s)
      後藤浄子、笠岡誠一、遠藤美智子、田中香、中島滋
    • Organizer
      第63回日本栄養・食糧学会総会
    • Place of Presentation
      長崎市、長崎県
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒスチジン摂取がラットの血糖値に及ぼす影響2009

    • Author(s)
      遠藤美智子、田中香、滝沢未来、笠岡誠一、中島滋
    • Organizer
      第63回日本栄養・食糧学会総会
    • Place of Presentation
      長崎市、長崎県
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation]2009

    • Author(s)
      Shigeru Nakajima, Hideaki Iwai, Soichiro Nakamura, Seiichi Kasaoka, Keiichi Ikeda, Yuko Amamiya, Fumiyuki Yamakura, Sachio Kawai, Shizuo Katamoto
    • Organizer
      237th American Chemical Society National Meeting & Exposition
    • Place of Presentation
      Salt Lake City, UT, USA
    • Year and Date
      2009-03-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒスチジン摂取によるラットの血中グルコース濃度低下作用2008

    • Author(s)
      遠藤美智子, 田中香, 滝沢未来, 笠岡誠一, 中島滋
    • Organizer
      第55回日本栄養改善学会学術総会
    • Place of Presentation
      鎌倉女子大学
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report
  • [Book] Seafood Quality, Safety, and Health(「Suppressive effects of marine foods intake on obesity and life style related diseases」)2010

    • Author(s)
      Shigeru Nakajima
    • Publisher
      The blackwell Publisher (United Kingdom)
    • Related Report
      2010 Final Research Report
  • [Book] 「Suppressive effects of marine foods intake on obesity and life style related diseases」 in 「Seafood Quality, Safety, and Health」2010

    • Author(s)
      Shigeru Nakajima
    • Publisher
      The blackwell Publisher (United Kingdom)
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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